5egu - Revision history

OCA at 06:26, 5 July 2023

2023-07-05T06:26:29Z

← Older revision		Revision as of 06:26, 5 July 2023
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	<StructureSection load='5egu' size='340' side='right'caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='5egu' size='340' side='right'caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5egu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EGU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5egu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EGU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NQ:3-BUTYL-8-[(6-BUTYL-5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYLMETHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.21Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NQ:3-BUTYL-8-[(6-BUTYL-5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYLMETHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egu OCA], [~~http~~://pdbe.org/5egu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5egu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5egu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5egu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egu OCA], [https://pdbe.org/5egu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5egu RCSB], [https://www.ebi.ac.uk/pdbsum/5egu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5egu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Betzi, S]]		[[Category: Betzi S]]
	[[Category: Morelli, X]]		[[Category: Morelli X]]
	[[Category: Priet, S]]		[[Category: Priet S]]
	[[Category: Raux, B]]		[[Category: Raux B]]
	[[Category: Rebuffet, E]]		[[Category: Rebuffet E]]
	~~[[Category: Brd4]]~~
	~~[[Category: Brd4_bd1]]~~
	~~[[Category: Brd4_bd1 06-nov]]~~
	~~[[Category: Bromodomain]]~~
	~~[[Category: Epigenetic reader]]~~
	~~[[Category: Histone]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Transcription~~]]

OCA at 06:57, 22 April 2020

2020-04-22T06:57:38Z

← Older revision		Revision as of 06:57, 22 April 2020
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	==FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione==		==FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione==
	<StructureSection load='5egu' size='340' side='right' caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='5egu' size='340' side='right'caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5egu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EGU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5egu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EGU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NQ:3-BUTYL-8-[(6-BUTYL-5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYLMETHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NQ:3-BUTYL-8-[(6-BUTYL-5,7-DIMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-YL)SULFANYLMETHYL]-7-ETHYL-PURINE-2,6-DIONE'>5NQ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egu OCA], [http://pdbe.org/5egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5egu RCSB], [http://www.ebi.ac.uk/pdbsum/5egu PDBsum]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egu OCA], [http://pdbe.org/5egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5egu RCSB], [http://www.ebi.ac.uk/pdbsum/5egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5egu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]		*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Betzi, S]]		[[Category: Betzi, S]]
	[[Category: Morelli, X]]		[[Category: Morelli, X]]

OCA at 19:47, 9 March 2016

2016-03-09T19:47:10Z

← Older revision		Revision as of 19:47, 9 March 2016
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	==FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione==		==FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione==
	<StructureSection load='5egu' size='340' side='right' caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>		<StructureSection load='5egu' size='340' side='right' caption='[[5egu]], [[Resolution\|resolution]] 2.21Å' scene=''>
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	</div>		</div>
	<div class="pdbe-citations 5egu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5egu" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:57, 20 January 2016

2016-01-20T16:57:59Z

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione==
-The entry 5egu is ON HOLD  until Paper Publication
+Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.,Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, Knapp S, Brunel JM, Fedorov AY, Collette Y, Roche P, Betzi S, Combes S, Morelli X J Med Chem. 2016 Jan 6. PMID:26735842<ref>PMID:26735842</ref>
-Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione
+<div class="pdbe-citations 5egu" style="background-color:#fffaf0;"></div>
-[[Category: Unreleased Structures]]
+== References ==
 [[Category: Raux, B]]
 [[Category: Rebuffet, E]]
-[[Category: Priet, S]]
+[[Category: Brd4]]

OCA at 14:39, 2 December 2015

2015-12-02T14:39:07Z

← Older revision		Revision as of 14:39, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5egu is ON HOLD		The entry 5egu is ON HOLD until Paper Publication

	Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X.		Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X.

OCA: Protected "5egu" [edit=sysop:move=sysop]

2015-12-01T02:48:55Z

Protected "5egu" [edit=sysop:move=sysop]

← Older revision	Revision as of 02:48, 1 December 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5egu is ON HOLD Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X. Description: FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX W...

2015-12-01T02:48:53Z

New page: '''Unreleased structure''' The entry 5egu is ON HOLD Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X. Description: FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX W...

New page

'''Unreleased structure'''

The entry 5egu is ON HOLD

Authors: Raux, B., Rebuffet, E., Betzi, S., Priet, S., Morelli, X.

Description: FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 3-Butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione
[[Category: Unreleased Structures]]
[[Category: Raux, B]]
[[Category: Morelli, X]]
[[Category: Betzi, S]]
[[Category: Rebuffet, E]]
[[Category: Priet, S]]