5emo - Revision history

OCA at 08:07, 12 July 2023

2023-07-12T08:07:09Z

← Older revision		Revision as of 08:07, 12 July 2023
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	<StructureSection load='5emo' size='340' side='right'caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='5emo' size='340' side='right'caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [~~http~~://pdbe.org/5emo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5emo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5emo ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.03Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [https://pdbe.org/5emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [https://www.ebi.ac.uk/pdbsum/5emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5emo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>		[https://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Dominguez, C~~]]		[[Category: Synthetic construct]]
	[[Category: ~~Feracci, M~~]]		[[Category: Dominguez C]]
	[[Category: ~~Protein - rna complexes star protein alternative splicing kh domain]]~~		[[Category: Feracci M]]
	~~[[Category: Rna binding protein~~]]

OCA at 07:05, 22 April 2020

2020-04-22T07:05:30Z

← Older revision		Revision as of 07:05, 22 April 2020
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	==Structure of the star domain of T-STAR in complex with AUUAAA RNA==		==Structure of the star domain of T-STAR in complex with AUUAAA RNA==
	<StructureSection load='5emo' size='340' side='right' caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='5emo' size='340' side='right'caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5emo ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5emo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Dominguez, C]]		[[Category: Dominguez, C]]
	[[Category: Feracci, M]]		[[Category: Feracci, M]]
	[[Category: Protein - rna complexes star protein alternative splicing kh domain]]		[[Category: Protein - rna complexes star protein alternative splicing kh domain]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 06:48, 6 October 2017

2017-10-06T06:48:08Z

← Older revision		Revision as of 06:48, 6 October 2017
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	==Structure of the star domain of T-STAR in complex with AUUAAA RNA==		==Structure of the star domain of T-STAR in complex with AUUAAA RNA==
	<StructureSection load='5emo' size='340' side='right' caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='5emo' size='340' side='right' caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5emo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:38, 27 January 2016

2016-01-27T18:38:57Z

← Older revision		Revision as of 18:38, 27 January 2016
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>		[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Sam68 and T-STAR are members of the STAR family of proteins that directly link signal transduction with post-transcriptional gene regulation. Sam68 controls the alternative splicing of many oncogenic proteins. T-STAR is a tissue-specific paralogue that regulates the alternative splicing of neuronal pre-mRNAs. STAR proteins differ from most splicing factors, in that they contain a single RNA-binding domain. Their specificity of RNA recognition is thought to arise from their property to homodimerize, but how dimerization influences their function remains unknown. Here, we establish at atomic resolution how T-STAR and Sam68 bind to RNA, revealing an unexpected mode of dimerization different from other members of the STAR family. We further demonstrate that this unique dimerization interface is crucial for their biological activity in splicing regulation, and suggest that the increased RNA affinity through dimer formation is a crucial parameter enabling these proteins to select their functional targets within the transcriptome.

			Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.,Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C Nat Commun. 2016 Jan 13;7:10355. doi: 10.1038/ncomms10355. PMID:26758068<ref>PMID:26758068</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5emo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:34, 13 January 2016

2016-01-13T20:34:13Z

← Older revision		Revision as of 20:34, 13 January 2016
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	'''~~Unreleased structure~~'''		==Structure of the star domain of T-STAR in complex with AUUAAA RNA==
			<StructureSection load='5emo' size='340' side='right' caption='[[5emo]], [[Resolution\|resolution]] 3.03Å' scene=''>
	~~The entry~~ 5emo is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5emo]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EMO FirstGlance]. <br>
	~~Authors~~: ~~Dominguez~~, C., ~~Feracci~~, M.		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emo OCA], [http://pdbe.org/5emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5emo RCSB], [http://www.ebi.ac.uk/pdbsum/5emo PDBsum]</span></td></tr>
			</table>
	~~Description~~: ~~Structure~~ of ~~the star domain~~ of T-~~STAR~~ in ~~complex with AUUAAA~~ RNA		== Function ==
	[~~[Category~~: ~~Unreleased Structures]]~~		[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Dominguez, C]]		[[Category: Dominguez, C]]
	[[Category: Feracci, M]]		[[Category: Feracci, M]]
			[[Category: Protein - rna complexes star protein alternative splicing kh domain]]
			[[Category: Rna binding protein]]

OCA: Protected "5emo" [edit=sysop:move=sysop]

2015-12-01T03:03:26Z

Protected "5emo" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:03, 1 December 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5emo is ON HOLD Authors: Dominguez, C., Feracci, M. Description: Structure of the star domain of T-STAR in complex with AUUAAA RNA [[Category: Unre...

2015-12-01T03:03:24Z

New page: '''Unreleased structure''' The entry 5emo is ON HOLD Authors: Dominguez, C., Feracci, M. Description: Structure of the star domain of T-STAR in complex with AUUAAA RNA [[Category: Unre...

New page

'''Unreleased structure'''

The entry 5emo is ON HOLD

Authors: Dominguez, C., Feracci, M.

Description: Structure of the star domain of T-STAR in complex with AUUAAA RNA
[[Category: Unreleased Structures]]
[[Category: Dominguez, C]]
[[Category: Feracci, M]]