5feb - Revision history

OCA at 06:48, 19 July 2023

2023-07-19T06:48:08Z

← Older revision		Revision as of 06:48, 19 July 2023
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	==Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain==		==Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain==
	<StructureSection load='5feb' size='340' side='right' caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5feb' size='340' side='right'caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5feb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5feb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FEB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5fdy\|5fdy]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SCN2B, UNQ326/PRO386 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [https://pdbe.org/5feb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [https://www.ebi.ac.uk/pdbsum/5feb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5feb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [~~http~~://pdbe.org/5feb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5feb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5feb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN]] Familial atrial fibrillation. The disease is caused by mutations affecting the gene represented in this entry. Genetic variations in SCN2B may be involved in Brugada syndrome (PubMed:23559163). This tachyarrhythmia is characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.<ref>PMID:23559163</ref>		[https://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN] Familial atrial fibrillation. The disease is caused by mutations affecting the gene represented in this entry. Genetic variations in SCN2B may be involved in Brugada syndrome (PubMed:23559163). This tachyarrhythmia is characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.<ref>PMID:23559163</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN]] Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).		[https://www.uniprot.org/uniprot/SCN2B_HUMAN SCN2B_HUMAN] Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5feb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5feb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Das, S~~]]		[[Category: Large Structures]]
	[[Category: ~~Petegem, F Van~~]]		[[Category: Das S]]
	[[Category: ~~Membrane protein]]~~		[[Category: Van Petegem F]]
	~~[[Category: Membrane protein ion channel sodium~~]]

OCA at 12:42, 6 November 2017

2017-11-06T12:42:23Z

← Older revision		Revision as of 12:42, 6 November 2017
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	<StructureSection load='5feb' size='340' side='right' caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5feb' size='340' side='right' caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5feb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5feb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fdy\|5fdy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fdy\|5fdy]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCN2B, UNQ326/PRO386 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [http://pdbe.org/5feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [http://www.ebi.ac.uk/pdbsum/5feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5feb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [http://pdbe.org/5feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [http://www.ebi.ac.uk/pdbsum/5feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5feb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Das, S]]		[[Category: Das, S]]
	[[Category: Petegem, F Van]]		[[Category: Petegem, F Van]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Membrane protein ion channel sodium]]		[[Category: Membrane protein ion channel sodium]]

OCA at 02:36, 13 July 2016

2016-07-13T02:36:44Z

← Older revision		Revision as of 02:36, 13 July 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fdy\|5fdy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fdy\|5fdy]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [http://pdbe.org/5feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [http://www.ebi.ac.uk/pdbsum/5feb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5feb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5feb OCA], [http://pdbe.org/5feb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5feb RCSB], [http://www.ebi.ac.uk/pdbsum/5feb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5feb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 15:43, 23 June 2016

2016-06-23T15:43:33Z

← Older revision		Revision as of 15:43, 23 June 2016
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	==A Sodium ~~channel~~ domain==		==Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain==
	<StructureSection load='5feb' size='340' side='right' caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5feb' size='340' side='right' caption='[[5feb]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 03:35, 10 March 2016

2016-03-10T03:35:53Z

@@ Line 1: / Line 1: @@
-The entry 5feb is ON HOLD  until Paper Publication
+==A Sodium channel domain==
-Authors: Das, S., Van Petegem, F.
+Binary architecture of the Nav1.2-beta2 signaling complex.,Das S, Gilchrist J, Bosmans F, Van Petegem F Elife. 2016 Feb 19;5. pii: e10960. doi: 10.7554/eLife.10960. PMID:26894959<ref>PMID:26894959</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Das, S]]
-[[Category: Van Petegem, F]]
+[[Category: Petegem, F Van]]

OCA at 12:57, 3 February 2016

2016-02-03T12:57:28Z

← Older revision		Revision as of 12:57, 3 February 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5feb is ON HOLD		The entry 5feb is ON HOLD until Paper Publication

	Authors: Das, S., Van Petegem, F.		Authors: Das, S., Van Petegem, F.

OCA: Protected "5feb" [edit=sysop:move=sysop]

2015-12-23T11:32:44Z

Protected "5feb" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:32, 23 December 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5feb is ON HOLD Authors: Das, S., Van Petegem, F. Description: Category: Unreleased Structures Category: Das, S [[Category: Van Petegem, F...

2015-12-23T11:32:43Z

New page: '''Unreleased structure''' The entry 5feb is ON HOLD Authors: Das, S., Van Petegem, F. Description: Category: Unreleased Structures Category: Das, S [[Category: Van Petegem, F...

New page

'''Unreleased structure'''

The entry 5feb is ON HOLD

Authors: Das, S., Van Petegem, F.

Description:
[[Category: Unreleased Structures]]
[[Category: Das, S]]
[[Category: Van Petegem, F]]