5fpp - Revision history

OCA at 13:17, 26 July 2023

2023-07-26T13:17:41Z

← Older revision		Revision as of 13:17, 26 July 2023
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	<StructureSection load='5fpp' size='340' side='right'caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5fpp' size='340' side='right'caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene~~></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5foq\|5foq]], [[5fpq\|5fpq]]</div></td></tr>~~
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [https://pdbe.org/5fpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [https://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [https://pdbe.org/5fpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [https://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.		[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Acetylcholinesterase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Akfur, C]]		[[Category: Akfur C]]
	[[Category: Allgardsson, A]]		[[Category: Allgardsson A]]
	[[Category: Berg, L]]		[[Category: Berg L]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom F]]
	[[Category: Hornberg, A]]		[[Category: Hornberg A]]
	[[Category: Linusson, A]]		[[Category: Linusson A]]
	[[Category: Worek, F]]		[[Category: Worek F]]
	~~[[Category: Density functional theory calculation]]~~
	~~[[Category: Hi-6]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Michaelis complex]]~~
	~~[[Category: Qm]]~~
	~~[[Category: Sarin~~]]

OCA at 09:26, 12 May 2021

2021-05-12T09:26:52Z

OCA at 07:30, 6 May 2020

2020-05-06T07:30:47Z

← Older revision		Revision as of 07:30, 6 May 2020
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	==Structure of a pre-reaction ternary complex between sarin- acetylcholinesterase and HI-6==		==Structure of a pre-reaction ternary complex between sarin- acetylcholinesterase and HI-6==
	<StructureSection load='5fpp' size='340' side='right' caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5fpp' size='340' side='right'caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5foq\|5foq]], [[5fpq\|5fpq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5foq\|5foq]], [[5fpq\|5fpq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [http://pdbe.org/5fpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [http://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [http://pdbe.org/5fpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [http://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]

OCA at 08:05, 17 January 2018

2018-01-17T08:05:24Z

← Older revision		Revision as of 08:05, 17 January 2018
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	<StructureSection load='5fpp' size='340' side='right' caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5fpp' size='340' side='right' caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5foq\|5foq]], [[5fpq\|5fpq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5foq\|5foq]], [[5fpq\|5fpq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [http://pdbe.org/5fpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [http://www.ebi.ac.uk/pdbsum/5fpp PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [http://pdbe.org/5fpp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [http://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5fpp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fpp" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
			[[Category: Lk3 transgenic mice]]
	[[Category: Akfur, C]]		[[Category: Akfur, C]]
	[[Category: Allgardsson, A]]		[[Category: Allgardsson, A]]

OCA at 16:50, 15 May 2016

2016-05-15T16:50:09Z

@@ Line 1: / Line 1: @@
-The entry 5fpp is ON HOLD  until Paper Publication
+==Structure of a pre-reaction ternary complex between sarin- acetylcholinesterase and HI-6==
-Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.
+Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.,Allgardsson A, Berg L, Akfur C, Hornberg A, Worek F, Linusson A, Ekstrom FJ Proc Natl Acad Sci U S A. 2016 May 2. pii: 201523362. PMID:27140636<ref>PMID:27140636</ref>
-Description: Structure of a pre-reaction ternary complex between sarin-acetylcholinesterase and HI-6
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Ekstrom, F]]
 [[Category: Hornberg, A]]
 [[Category: Worek, F]]
-[[Category: Linusson, A]]
+[[Category: Density functional theory calculation]]
-[[Category: Allgardsson, A]]
+[[Category: Hi-6]]
-[[Category: Berg, L]]
+[[Category: Hydrolase]]

OCA at 23:03, 10 May 2016

2016-05-10T23:03:54Z

← Older revision		Revision as of 23:03, 10 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5fpp is ON HOLD		The entry 5fpp is ON HOLD until Paper Publication

	Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.		Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.

OCA at 11:46, 23 December 2015

2015-12-23T11:46:47Z

← Older revision		Revision as of 11:46, 23 December 2015
Line 5:		Line 5:
	Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.		Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.

	Description: Structure of a pre-reaction ~~ternay~~ complex between sarin-acetylcholinesterase and HI-6		Description: Structure of a pre-reaction ternary complex between sarin-acetylcholinesterase and HI-6
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ekstrom, F]]		[[Category: Ekstrom, F]]

OCA at 13:00, 16 December 2015

2015-12-16T13:00:13Z

← Older revision		Revision as of 13:00, 16 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5fpp is ON HOLD ~~until sometime in the future~~		The entry 5fpp is ON HOLD

	Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.		Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.

OCA: Protected "5fpp" [edit=sysop:move=sysop]

2015-12-09T12:52:51Z

Protected "5fpp" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:52, 9 December 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5fpp is ON HOLD until sometime in the future Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F. Desc...

2015-12-09T12:52:50Z

New page: '''Unreleased structure''' The entry 5fpp is ON HOLD until sometime in the future Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F. Desc...

New page

'''Unreleased structure'''

The entry 5fpp is ON HOLD until sometime in the future

Authors: Allgardsson, A., Berg, L., Akfur, C., Hornberg, A., Worek, F., Linusson, A., Ekstrom, F.

Description: Structure of a pre-reaction ternay complex between sarin-acetylcholinesterase and HI-6
[[Category: Unreleased Structures]]
[[Category: Ekstrom, F]]
[[Category: Akfur, C]]
[[Category: Hornberg, A]]
[[Category: Worek, F]]
[[Category: Linusson, A]]
[[Category: Allgardsson, A]]
[[Category: Berg, L]]

← Older revision		Revision as of 09:26, 12 May 2021
Line 3:		Line 3:
	<StructureSection load='5fpp' size='340' side='right'caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5fpp' size='340' side='right'caption='[[5fpp]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FPP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fpp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE3:2-(2-ETHOXYETHOXY)ETHANOL'>AE3</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HI6:4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM'>HI6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SGB:O-[(S)-METHYL(1-METHYLETHOXY)PHOSPHORYL]-L-SERINE'>SGB</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5foq\|5foq]], [[5fpq\|5fpq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5foq\|5foq]], [[5fpq\|5fpq]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [~~http~~://pdbe.org/5fpp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpp OCA], [https://pdbe.org/5fpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fpp RCSB], [https://www.ebi.ac.uk/pdbsum/5fpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.		[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==