5fvs - Revision history

OCA at 13:28, 26 July 2023

2023-07-26T13:28:55Z

← Older revision		Revision as of 13:28, 26 July 2023
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	<StructureSection load='5fvs' size='340' side='right'caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fvs' size='340' side='right'caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.948Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvp\|5fvp]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [https://pdbe.org/5fvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [https://www.ebi.ac.uk/pdbsum/5fvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvs ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [~~http~~://pdbe.org/5fvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.		[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Li, H~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Poulos, T L~~]]		[[Category: Li H]]
	[[Category: ~~Inhibitor complex]]~~		[[Category: Poulos TL]]
	~~[[Category: Nitric oxide synthase]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 07:39, 6 May 2020

2020-05-06T07:39:38Z

← Older revision		Revision as of 07:39, 6 May 2020
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	==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine==		==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine==
	<StructureSection load='5fvs' size='340' side='right' caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fvs' size='340' side='right'caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvp\|5fvp]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvp\|5fvp]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [http://pdbe.org/5fvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [http://www.ebi.ac.uk/pdbsum/5fvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [http://pdbe.org/5fvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [http://www.ebi.ac.uk/pdbsum/5fvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5fvs" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fvs" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 12:37, 16 November 2017

2017-11-16T12:37:43Z

← Older revision		Revision as of 12:37, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5fvs' size='340' side='right' caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fvs' size='340' side='right' caption='[[5fvs]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fvs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=W66:4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE'>W66</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvp\|5fvp]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvp\|5fvp]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [http://pdbe.org/5fvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [http://www.ebi.ac.uk/pdbsum/5fvs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvs OCA], [http://pdbe.org/5fvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvs RCSB], [http://www.ebi.ac.uk/pdbsum/5fvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Buffalo rat]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 18:45, 12 May 2016

2016-05-12T18:45:39Z

@@ Line 1: / Line 1: @@
-The entry 5fvs is ON HOLD  until Paper Publication
+==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine==
-Authors: Li, H., Poulos, T.L.
+Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.,Wang HY, Qin Y, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB J Med Chem. 2016 Apr 20. PMID:27050842<ref>PMID:27050842</ref>
-Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Poulos, T.L]]
+<div class="pdbe-citations 5fvs" style="background-color:#fffaf0;"></div>
 [[Category: Li, H]]

OCA at 12:15, 2 March 2016

2016-03-02T12:15:23Z

← Older revision		Revision as of 12:15, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5fvs is ON HOLD		The entry 5fvs is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

OCA: Protected "5fvs" [edit=sysop:move=sysop]

2016-02-21T00:28:31Z

Protected "5fvs" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:28, 21 February 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5fvs is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(...

2016-02-21T00:28:30Z

New page: '''Unreleased structure''' The entry 5fvs is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(...

New page

'''Unreleased structure'''

The entry 5fvs is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-(2-(5-(3-(methylamino)propyl)pyridin-3-yl) ethyl)pyridin-2-amine
[[Category: Unreleased Structures]]
[[Category: Poulos, T.L]]
[[Category: Li, H]]