5gap - Revision history

OCA at 13:41, 26 July 2023

2023-07-26T13:41:41Z

← Older revision		Revision as of 13:41, 26 July 2023
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	<SX load='5gap' size='340' side='right' viewer='molstar' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='5gap' size='340' side='right' viewer='molstar' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5gap]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GAP FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/RNA_helicase RNA helicase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~3.6~~.4.13 3.6.4.13] </span>~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [https://pdbe.org/5gap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [https://www.ebi.ac.uk/pdbsum/5gap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gap ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [~~http~~://pdbe.org/5gap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PRP4_YEAST PRP4_YEAST]] Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly. [[http://www.uniprot.org/uniprot/SNU13_YEAST SNU13_YEAST]] Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.<ref>PMID:11081632</ref> <ref>PMID:12215523</ref> <ref>PMID:14730029</ref> [[http://www.uniprot.org/uniprot/PRP6_YEAST PRP6_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. [[http://www.uniprot.org/uniprot/PRP31_YEAST PRP31_YEAST]] Promotes the association of the U4/U6.U5 tri-snRNP particle with pre-spliceosomes to form the mature spliceosomal complex.<ref>PMID:8604353</ref> [[http://www.uniprot.org/uniprot/BRR2_YEAST BRR2_YEAST]] RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.<ref>PMID:19098916</ref> <ref>PMID:23124065</ref> <ref>PMID:19716790</ref> <ref>PMID:19525970</ref> [[http://www.uniprot.org/uniprot/DIB1_YEAST DIB1_YEAST]] Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis. [[http://www.uniprot.org/uniprot/PRP3_YEAST PRP3_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.<ref>PMID:9326489</ref> [[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>		[https://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
			*[[Helicase 3D structures\|Helicase 3D structures]]
	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]		*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
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	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: RNA helicase]]~~
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bai~~, X C~~]]		[[Category: Bai XC]]
	[[Category: Galej~~, W P~~]]		[[Category: Galej WP]]
	[[Category: Nagai, K]]		[[Category: Nagai K]]
	[[Category: Newman, A]]		[[Category: Newman A]]
	[[Category: Nguyen~~, T H.D~~]]		[[Category: Nguyen THD]]
	[[Category: Oubridge, C]]		[[Category: Oubridge C]]
	[[Category: Scheres, S]]		[[Category: Scheres S]]
	~~[[Category: Rna-protein complex]]~~
	~~[[Category: Snrnp]]~~
	~~[[Category: Spliceosome]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: U4/u6 u5 snrnp~~]]

OCA at 20:03, 10 April 2020

2020-04-10T20:03:47Z

← Older revision		Revision as of 20:03, 10 April 2020
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	<SX load='5gap' size='340' side='right' viewer='molstar' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='5gap' size='340' side='right' viewer='molstar' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GAP FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [http://pdbe.org/5gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [http://www.ebi.ac.uk/pdbsum/5gap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gap ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [http://pdbe.org/5gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [http://www.ebi.ac.uk/pdbsum/5gap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:27, 6 March 2020

2020-03-06T18:27:01Z

← Older revision		Revision as of 18:27, 6 March 2020
Line 1:		Line 1:

	==Body region of the U4/U6.U5 tri-snRNP==		==Body region of the U4/U6.U5 tri-snRNP==
	<~~StructureSection~~ load='5gap' size='340' side='right'caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='5gap' size='340' side='right' viewer='molstar' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GAP FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor~~]]		*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</~~StructureSection~~>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RNA helicase]]		[[Category: RNA helicase]]

OCA at 10:49, 2 October 2019

2019-10-02T10:49:31Z

← Older revision		Revision as of 10:49, 2 October 2019
Line 1:		Line 1:

	==Body region of the U4/U6.U5 tri-snRNP==		==Body region of the U4/U6.U5 tri-snRNP==
	<StructureSection load='5gap' size='340' side='right' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='5gap' size='340' side='right'caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GAP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GAP FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [http://pdbe.org/5gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [http://www.ebi.ac.uk/pdbsum/5gap PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [http://pdbe.org/5gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [http://www.ebi.ac.uk/pdbsum/5gap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gap ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5gap" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gap" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: RNA helicase]]		[[Category: RNA helicase]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 06:57, 2 March 2016

2016-03-02T06:57:17Z

@@ Line 1: / Line 1: @@
 ==Body region of the U4/U6.U5 tri-snRNP==
 <StructureSection load='5gap' size='340' side='right' caption='[[5gap]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
@@ Line 9: / Line 10: @@
 == Function ==
 [[http://www.uniprot.org/uniprot/PRP4_YEAST PRP4_YEAST]] Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly. [[http://www.uniprot.org/uniprot/SNU13_YEAST SNU13_YEAST]] Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.<ref>PMID:11081632</ref> <ref>PMID:12215523</ref> <ref>PMID:14730029</ref>  [[http://www.uniprot.org/uniprot/PRP6_YEAST PRP6_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. [[http://www.uniprot.org/uniprot/PRP31_YEAST PRP31_YEAST]] Promotes the association of the U4/U6.U5 tri-snRNP particle with pre-spliceosomes to form the mature spliceosomal complex.<ref>PMID:8604353</ref>  [[http://www.uniprot.org/uniprot/BRR2_YEAST BRR2_YEAST]] RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.<ref>PMID:19098916</ref> <ref>PMID:23124065</ref> <ref>PMID:19716790</ref> <ref>PMID:19525970</ref>  [[http://www.uniprot.org/uniprot/DIB1_YEAST DIB1_YEAST]] Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis. [[http://www.uniprot.org/uniprot/PRP3_YEAST PRP3_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.<ref>PMID:9326489</ref>  [[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
 == References ==
 <references/>

OCA at 02:39, 28 January 2016

2016-01-28T02:39:16Z

← Older revision		Revision as of 02:39, 28 January 2016
Line 1:		Line 1:
	'''~~Unreleased structure~~'''		==Body region of the U4/U6.U5 tri-snRNP==
			<StructureSection load='5gap' size='340' side='right' caption='[[5gap]], [[Resolution\|resolution]] 3.60Å' scene=''>
	~~The entry~~ 5gap is ~~ON HOLD~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5gap]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GAP FirstGlance]. <br>
	~~Authors~~: ~~Nguyen~~, T.H.D., ~~Galej~~, W.P., ~~Oubridge~~, C., ~~Bai~~, X.C., ~~Newman~~, A., ~~Scheres~~, S., Nagai, K.		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
	~~Description~~:		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gap OCA], [http://pdbe.org/5gap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gap RCSB], [http://www.ebi.ac.uk/pdbsum/5gap PDBsum]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PRP4_YEAST PRP4_YEAST]] Involved in RNA splicing. Is required for the association of U4/U6 snRNP with U5 snRNP in an early step of spliceosome assembly. [[http://www.uniprot.org/uniprot/SNU13_YEAST SNU13_YEAST]] Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.<ref>PMID:11081632</ref> <ref>PMID:12215523</ref> <ref>PMID:14730029</ref> [[http://www.uniprot.org/uniprot/PRP6_YEAST PRP6_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. [[http://www.uniprot.org/uniprot/PRP31_YEAST PRP31_YEAST]] Promotes the association of the U4/U6.U5 tri-snRNP particle with pre-spliceosomes to form the mature spliceosomal complex.<ref>PMID:8604353</ref> [[http://www.uniprot.org/uniprot/BRR2_YEAST BRR2_YEAST]] RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.<ref>PMID:19098916</ref> <ref>PMID:23124065</ref> <ref>PMID:19716790</ref> <ref>PMID:19525970</ref> [[http://www.uniprot.org/uniprot/DIB1_YEAST DIB1_YEAST]] Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis. [[http://www.uniprot.org/uniprot/PRP3_YEAST PRP3_YEAST]] Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.<ref>PMID:9326489</ref> [[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: RNA helicase]]
			[[Category: Saccharomyces cerevisiae]]
			[[Category: Bai, X C]]
			[[Category: Galej, W P]]
			[[Category: Nagai, K]]
			[[Category: Newman, A]]
			[[Category: Nguyen, T H.D]]
	[[Category: Oubridge, C]]		[[Category: Oubridge, C]]
	~~[[Category: Nagai, K]]~~
	~~[[Category: Galej, W.P]]~~
	~~[[Category: Bai, X.C]]~~
	[[Category: Scheres, S]]		[[Category: Scheres, S]]
	[[Category: ~~Nguyen, T.H.D~~]]		[[Category: Rna-protein complex]]
	[[Category: ~~Newman, A~~]]		[[Category: Snrnp]]
			[[Category: Spliceosome]]
			[[Category: Transcription]]
			[[Category: U4/u6 u5 snrnp]]

OCA at 15:05, 20 January 2016

2016-01-20T15:05:38Z

← Older revision		Revision as of 15:05, 20 January 2016
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	The entry 5gap is ON HOLD		The entry 5gap is ON HOLD

	Authors: Nguyen, T.H.D, Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.		Authors: Nguyen, T.H.D., Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.

	Description:		Description:
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	[[Category: Oubridge, C]]		[[Category: Oubridge, C]]
	[[Category: Nagai, K]]		[[Category: Nagai, K]]
			[[Category: Galej, W.P]]
	[[Category: Bai, X.C]]		[[Category: Bai, X.C]]
	[[Category: Scheres, S]]		[[Category: Scheres, S]]
			[[Category: Nguyen, T.H.D]]
	[[Category: Newman, A]]		[[Category: Newman, A]]
	~~[[Category: Nguyen, T.H.D, Galej, W.P]]~~

OCA: Protected "5gap" [edit=sysop:move=sysop]

2015-12-23T11:52:38Z

Protected "5gap" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:52, 23 December 2015
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5gap is ON HOLD Authors: Nguyen, T.H.D, Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K. Description: [[Category: Unreleas...

2015-12-23T11:52:37Z

New page: '''Unreleased structure''' The entry 5gap is ON HOLD Authors: Nguyen, T.H.D, Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K. Description: [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 5gap is ON HOLD

Authors: Nguyen, T.H.D, Galej, W.P., Oubridge, C., Bai, X.C., Newman, A., Scheres, S., Nagai, K.

Description:
[[Category: Unreleased Structures]]
[[Category: Oubridge, C]]
[[Category: Nagai, K]]
[[Category: Bai, X.C]]
[[Category: Scheres, S]]
[[Category: Newman, A]]
[[Category: Nguyen, T.H.D, Galej, W.P]]