5hyp - Revision history

OCA at 11:00, 16 August 2023

2023-08-16T11:00:37Z

← Older revision		Revision as of 11:00, 16 August 2023
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	<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution\|resolution]] 3.02Å' scene=''>		<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution\|resolution]] 3.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HYP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5hyu\|5hyu]], [[5hyt\|5hyt]], [[5hzp\|5hzp]], [[5i0q\|5i0q]]</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.024Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">C4BPA, C4BP ([http://www.ncbi.nlm~~.~~nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=9606 HUMAN]), emm28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [https://pdbe.org/5hyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [https://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [~~http~~://pdbe.org/5hyp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.		[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Micrococcus scarlatinae klein 1884]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Bahn-Suh, A J~~]]		[[Category: Streptococcus pyogenes]]
	[[Category: ~~Buffalo, C Z~~]]		[[Category: Bahn-Suh AJ]]
	[[Category: ~~Ghosh, P~~]]		[[Category: Buffalo CZ]]
	[[Category: ~~Complement]]~~		[[Category: Ghosh P]]
	~~[[Category: Hypervariable antigen]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: M protein]]~~
	~~[[Category: Streptococcus pyogene~~]]

OCA at 16:14, 11 December 2019

2019-12-11T16:14:56Z

← Older revision		Revision as of 16:14, 11 December 2019
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	==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein==		==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein==
	<StructureSection load='5hyp' size='340' side='right' caption='[[5hyp]], [[Resolution\|resolution]] 3.02Å' scene=''>		<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution\|resolution]] 3.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyt\|5hyt]], [[5hzp\|5hzp]], [[5i0q\|5i0q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyt\|5hyt]], [[5hzp\|5hzp]], [[5i0q\|5i0q]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C4BPA, C4BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), emm28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Micrococcus scarlatinae klein 1884]]
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bahn-Suh, A J]]		[[Category: Bahn-Suh, A J]]
	[[Category: Buffalo, C Z]]		[[Category: Buffalo, C Z]]

OCA at 11:16, 26 October 2016

2016-10-26T11:16:57Z

@@ Line 9: / Line 9: @@
 == Function ==
 [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
 __TOC__
 </StructureSection>

OCA at 15:34, 26 July 2016

2016-07-26T15:34:47Z

← Older revision		Revision as of 15:34, 26 July 2016
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	~~'''Unreleased structure'''~~

	~~The entry 5hyp is ON HOLD until Paper Publication~~		==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein==
			<StructureSection load='5hyp' size='340' side='right' caption='[[5hyp]], [[Resolution\|resolution]] 3.02Å' scene=''>
	~~Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
	~~Description:~~ Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyt\|5hyt]], [[5hzp\|5hzp]], [[5i0q\|5i0q]]</td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
	[[Category: Bahn-Suh, A.J]]		</table>
	[[Category: Buffalo, C.Z]]		== Function ==
			[[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
			__TOC__
			</StructureSection>
			[[Category: Bahn-Suh, A J]]
			[[Category: Buffalo, C Z]]
	[[Category: Ghosh, P]]		[[Category: Ghosh, P]]
			[[Category: Complement]]
			[[Category: Hypervariable antigen]]
			[[Category: Immune system]]
			[[Category: M protein]]
			[[Category: Streptococcus pyogene]]

OCA at 00:03, 11 May 2016

2016-05-11T00:03:20Z

← Older revision		Revision as of 00:03, 11 May 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5hyp is ON HOLD		The entry 5hyp is ON HOLD until Paper Publication

	Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.		Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.

OCA: Protected "5hyp" [edit=sysop:move=sysop]

2016-02-10T15:55:01Z

Protected "5hyp" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:55, 10 February 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5hyp is ON HOLD Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P. Description: Structure of human C4b-binding protein alpha cain CCP domains 1 and ...

2016-02-10T15:55:00Z

New page: '''Unreleased structure''' The entry 5hyp is ON HOLD Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P. Description: Structure of human C4b-binding protein alpha cain CCP domains 1 and ...

New page

'''Unreleased structure'''

The entry 5hyp is ON HOLD

Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.

Description: Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein
[[Category: Unreleased Structures]]
[[Category: Bahn-Suh, A.J]]
[[Category: Buffalo, C.Z]]
[[Category: Ghosh, P]]