5icf - Revision history

OCA at 13:45, 30 August 2023

2023-08-30T13:45:33Z

← Older revision		Revision as of 13:45, 30 August 2023
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	<StructureSection load='5icf' size='340' side='right'caption='[[5icf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5icf' size='340' side='right'caption='[[5icf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5icf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thlfg Thlfg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ICF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5icf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thalictrum_flavum_subsp._glaucum Thalictrum flavum subsp. glaucum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ICF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(RS)-norcoclaurine_6-O-methyltransferase (RS)-norcoclaurine 6-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.128 2.1.1.128] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [~~http~~://pdbe.org/5icf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5icf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5icf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [https://pdbe.org/5icf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [https://www.ebi.ac.uk/pdbsum/5icf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5icf ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/6OMT_THLFG 6OMT_THLFG] Involved in the biosynthesis of coclaurine, a precursor of benzylisoquinoline alkaloids (PubMed:27232113). Catalyzes the transfer of the S-methyl group of S-adenosyl-L-methionine (AdoMet) to the 6-hydroxyl group of norcoclaurine to form coclaurine (PubMed:27232113).<ref>PMID:27232113</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Thlfg~~]]		[[Category: Thalictrum flavum subsp. glaucum]]
	[[Category: Dumas, R]]		[[Category: Dumas R]]
	[[Category: Giustini, C]]		[[Category: Giustini C]]
	[[Category: Graindorge, M]]		[[Category: Graindorge M]]
	[[Category: Matringe, M]]		[[Category: Matringe M]]
	[[Category: Robin~~, A Y]]~~		[[Category: Robin AY]]
	~~[[Category: Benzylisoquinoline alkaloid]]~~
	~~[[Category: Methyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 07:12, 3 June 2020

2020-06-03T07:12:56Z

← Older revision		Revision as of 07:12, 3 June 2020
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	==Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and sanguinarine==		==Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and sanguinarine==
	<StructureSection load='5icf' size='340' side='right' caption='[[5icf]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5icf' size='340' side='right'caption='[[5icf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5icf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5ICF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5icf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thlfg Thlfg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ICF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(RS)-norcoclaurine_6-O-methyltransferase (RS)-norcoclaurine 6-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.128 2.1.1.128] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(RS)-norcoclaurine_6-O-methyltransferase (RS)-norcoclaurine 6-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.128 2.1.1.128] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [http://pdbe.org/5icf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [http://www.ebi.ac.uk/pdbsum/5icf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5icf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [http://pdbe.org/5icf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [http://www.ebi.ac.uk/pdbsum/5icf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5icf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Thlfg]]
	[[Category: Dumas, R]]		[[Category: Dumas, R]]
	[[Category: Giustini, C]]		[[Category: Giustini, C]]

OCA at 09:41, 19 October 2016

2016-10-19T09:41:34Z

← Older revision		Revision as of 09:41, 19 October 2016
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(RS)-norcoclaurine_6-O-methyltransferase (RS)-norcoclaurine 6-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.128 2.1.1.128] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(RS)-norcoclaurine_6-O-methyltransferase (RS)-norcoclaurine 6-O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.128 2.1.1.128] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [http://pdbe.org/5icf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [http://www.ebi.ac.uk/pdbsum/5icf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5icf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icf OCA], [http://pdbe.org/5icf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icf RCSB], [http://www.ebi.ac.uk/pdbsum/5icf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5icf ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:26, 20 June 2016

2016-06-20T15:26:27Z

@@ Line 1: / Line 1: @@
-The entry 5icf is ON HOLD  until Paper Publication
+==Crystal structure of (S)-norcoclaurine 6-O-methyltransferase with S-adenosyl-L-homocysteine and sanguinarine==
-Authors:
+Crystal structure of norcoclaurine-6-O-methyltransferase a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids.,Robin AY, Giustini C, Graindorge M, Matringe M, Dumas R Plant J. 2016 May 27. doi: 10.1111/tpj.13225. PMID:27232113<ref>PMID:27232113</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 14:19, 15 May 2016

2016-05-15T14:19:32Z

← Older revision		Revision as of 14:19, 15 May 2016
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	The entry 5icf is ON HOLD until Paper Publication		The entry 5icf is ON HOLD until Paper Publication

	Authors: ~~Robin, A.Y., Graindorge, M., Giustini, C., Dumas, R., Matringe, M.~~		Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Robin, A.Y]]~~
	~~[[Category: Giustini, C]]~~
	~~[[Category: Graindorge, M]]~~
	~~[[Category: Dumas, R]]~~
	~~[[Category: Matringe, M]]~~

OCA: Protected "5icf" [edit=sysop:move=sysop]

2016-03-02T13:43:46Z

Protected "5icf" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:43, 2 March 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5icf is ON HOLD until Paper Publication Authors: Robin, A.Y., Graindorge, M., Giustini, C., Dumas, R., Matringe, M. Description: [[Category: Unrel...

2016-03-02T13:43:45Z

New page: '''Unreleased structure''' The entry 5icf is ON HOLD until Paper Publication Authors: Robin, A.Y., Graindorge, M., Giustini, C., Dumas, R., Matringe, M. Description: [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 5icf is ON HOLD until Paper Publication

Authors: Robin, A.Y., Graindorge, M., Giustini, C., Dumas, R., Matringe, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Robin, A.Y]]
[[Category: Giustini, C]]
[[Category: Graindorge, M]]
[[Category: Dumas, R]]
[[Category: Matringe, M]]