5irc - Revision history

OCA at 14:06, 30 August 2023

2023-08-30T14:06:56Z

← Older revision		Revision as of 14:06, 30 August 2023
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	<StructureSection load='5irc' size='340' side='right'caption='[[5irc]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='5irc' size='340' side='right'caption='[[5irc]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5irc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IRC FirstGlance]. <br>		<table><tr><td colspan='2'>[[5irc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IRC FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'~~>~~CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5~~-~~DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.72Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene><~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">Arhgap35, Grlf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=10116 Buffalo rat]), RHOA, ARH12, ARHA, RHO12 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irc OCA], [https://pdbe.org/5irc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5irc RCSB], [https://www.ebi.ac.uk/pdbsum/5irc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5irc ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irc OCA], [~~http~~://pdbe.org/5irc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5irc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5irc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5irc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/RHG35_RAT RHG35_RAT]] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (By similarity). [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[https://www.uniprot.org/uniprot/RHG35_RAT RHG35_RAT] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Buffalo rat]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Derewenda, U~~]]		[[Category: Rattus norvegicus]]
	[[Category: Derewenda~~, Z~~]]		[[Category: Derewenda U]]
	[[Category: ~~Gap domain]]~~		[[Category: Derewenda Z]]
	~~[[Category: Gtpase]]~~
	~~[[Category: Protein binding]]~~
	~~[[Category: Protein-protein complex]]~~
	~~[[Category: Transition state~~]]

OCA at 11:51, 25 December 2019

2019-12-25T11:51:28Z

← Older revision		Revision as of 11:51, 25 December 2019
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	==p190A GAP domain complex with RhoA==		==p190A GAP domain complex with RhoA==
	<StructureSection load='5irc' size='340' side='right' caption='[[5irc]], [[Resolution\|resolution]] 1.72Å' scene=''>		<StructureSection load='5irc' size='340' side='right'caption='[[5irc]], [[Resolution\|resolution]] 1.72Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5irc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRC FirstGlance]. <br>		<table><tr><td colspan='2'>[[5irc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MGF:TRIFLUOROMAGNESATE'>MGF</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arhgap35, Grlf1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irc OCA], [http://pdbe.org/5irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irc RCSB], [http://www.ebi.ac.uk/pdbsum/5irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5irc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irc OCA], [http://pdbe.org/5irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irc RCSB], [http://www.ebi.ac.uk/pdbsum/5irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5irc ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
			*[[Rho GTPase activating protein 3D structures\|Rho GTPase activating protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Buffalo rat]]
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Derewenda, U]]		[[Category: Derewenda, U]]
	[[Category: Derewenda, Z]]		[[Category: Derewenda, Z]]

OCA at 17:45, 15 November 2017

2017-11-15T17:45:00Z

← Older revision		Revision as of 17:45, 15 November 2017
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	</div>		</div>
	<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Rho GTPase\|Rho GTPase]]
	*[[Rho GTPase activating protein\|Rho GTPase activating protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:41, 21 September 2017

2017-09-21T04:41:48Z

← Older revision		Revision as of 04:41, 21 September 2017
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	</div>		</div>
	<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5irc" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Rho GTPase\|Rho GTPase]]
			*[[Rho GTPase activating protein\|Rho GTPase activating protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:04, 10 September 2016

2016-09-10T00:04:03Z

@@ Line 1: / Line 1: @@
-The entry 5irc is ON HOLD  until Paper Publication
+==p190A GAP domain complex with RhoA==
-Authors: Derewenda, U., Derewenda, Z.
+Deciphering the molecular and functional basis of RhoGAP family proteins: A systematic approach towards selective inactivation of Rho family proteins.,Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenstrom P, Somlyo AV, Dvorsky R, Ahmadian MR J Biol Chem. 2016 Aug 1. pii: jbc.M116.736967. PMID:27481945<ref>PMID:27481945</ref>
-Description: p190A GAP domain complex with RhoA
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Derewenda, Z]]
-[[Category: Derewenda, U]]
+[[Category: Gap domain]]

OCA at 22:40, 12 July 2016

2016-07-12T22:40:59Z

← Older revision		Revision as of 22:40, 12 July 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5irc is ON HOLD		The entry 5irc is ON HOLD until Paper Publication

	Authors: Derewenda, U., Derewenda, Z.		Authors: Derewenda, U., Derewenda, Z.

OCA: Protected "5irc" [edit=sysop:move=sysop]

2016-05-11T00:49:26Z

Protected "5irc" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:49, 11 May 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5irc is ON HOLD Authors: Derewenda, U., Derewenda, Z. Description: p190A GAP domain complex with RhoA Category: Unreleased Structures [[Categor...

2016-05-11T00:49:25Z

New page: '''Unreleased structure''' The entry 5irc is ON HOLD Authors: Derewenda, U., Derewenda, Z. Description: p190A GAP domain complex with RhoA Category: Unreleased Structures [[Categor...

New page

'''Unreleased structure'''

The entry 5irc is ON HOLD

Authors: Derewenda, U., Derewenda, Z.

Description: p190A GAP domain complex with RhoA
[[Category: Unreleased Structures]]
[[Category: Derewenda, Z]]
[[Category: Derewenda, U]]