5iry - Revision history

OCA at 14:07, 30 August 2023

2023-08-30T14:07:25Z

← Older revision		Revision as of 14:07, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='5iry' size='340' side='right'caption='[[5iry]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5iry' size='340' side='right'caption='[[5iry]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IRY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.095Å</td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSC1, CDHF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [~~http~~://pdbe.org/5iry PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5iry PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5iry ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [https://pdbe.org/5iry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [https://www.ebi.ac.uk/pdbsum/5iry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5iry ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DSC1_HUMAN DSC1_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.		[https://www.uniprot.org/uniprot/DSC1_HUMAN DSC1_HUMAN] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brasch, J]]		[[Category: Brasch J]]
	[[Category: Harrison~~, O J~~]]		[[Category: Harrison OJ]]
	[[Category: Shapiro, L]]		[[Category: Shapiro L]]
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Cell surface]]~~
	~~[[Category: Desmosome]]~~
	~~[[Category: Extracellular cadherin domain~~]]

OCA at 11:51, 25 December 2019

2019-12-25T11:51:42Z

← Older revision		Revision as of 11:51, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of human Desmocollin-1 ectodomain==		==Crystal structure of human Desmocollin-1 ectodomain==
	<StructureSection load='5iry' size='340' side='right' caption='[[5iry]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5iry' size='340' side='right'caption='[[5iry]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DSC1, CDHF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [http://pdbe.org/5iry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [http://www.ebi.ac.uk/pdbsum/5iry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iry ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [http://pdbe.org/5iry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [http://www.ebi.ac.uk/pdbsum/5iry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iry ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Brasch, J]]		[[Category: Brasch, J]]
	[[Category: Harrison, O J]]		[[Category: Harrison, O J]]

OCA at 17:45, 15 November 2017

2017-11-15T17:45:07Z

← Older revision		Revision as of 17:45, 15 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Cadherin\|Cadherin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:40, 21 September 2017

2017-09-21T04:40:46Z

← Older revision		Revision as of 04:40, 21 September 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Cadherin\|Cadherin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:02, 12 July 2016

2016-07-12T18:02:29Z

← Older revision		Revision as of 18:02, 12 July 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [http://pdbe.org/5iry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [http://www.ebi.ac.uk/pdbsum/5iry PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [http://pdbe.org/5iry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [http://www.ebi.ac.uk/pdbsum/5iry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iry ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DSC1_HUMAN DSC1_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.		[[http://www.uniprot.org/uniprot/DSC1_HUMAN DSC1_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical cadherins. However, conserved charged amino acids inhibit Dsg:Dsg and Dsc:Dsc interactions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charge attraction. These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of desmosomes and provide a structural framework for understanding desmosome assembly.

			Structural basis of adhesive binding by desmocollins and desmogleins.,Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5. doi:, 10.1073/pnas.1606272113. Epub 2016 Jun 13. PMID:27298358<ref>PMID:27298358</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5iry" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 23:28, 23 June 2016

2016-06-23T23:28:30Z

← Older revision		Revision as of 23:28, 23 June 2016
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5iry is ~~ON HOLD until Paper Publication~~		==Crystal structure of human Desmocollin-1 ectodomain==
			<StructureSection load='5iry' size='340' side='right' caption='[[5iry]], [[Resolution\|resolution]] 3.10Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[5iry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRY FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iry OCA], [http://pdbe.org/5iry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iry RCSB], [http://www.ebi.ac.uk/pdbsum/5iry PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DSC1_HUMAN DSC1_HUMAN]] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
			__TOC__
			</StructureSection>
			[[Category: Brasch, J]]
			[[Category: Harrison, O J]]
			[[Category: Shapiro, L]]
			[[Category: Cell adhesion]]
			[[Category: Cell surface]]
			[[Category: Desmosome]]
			[[Category: Extracellular cadherin domain]]

OCA at 14:40, 15 May 2016

2016-05-15T14:40:55Z

← Older revision		Revision as of 14:40, 15 May 2016
Line 3:		Line 3:
	The entry 5iry is ON HOLD until Paper Publication		The entry 5iry is ON HOLD until Paper Publication

	Authors: ~~Brasch, J., Harrison, O.J., Shapiro, L.~~		Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Shapiro, L]]~~
	~~[[Category: Harrison, O.J]]~~
	~~[[Category: Brasch, J]]~~

OCA: Protected "5iry" [edit=sysop:move=sysop]

2016-05-11T00:50:49Z

Protected "5iry" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:50, 11 May 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5iry is ON HOLD until Paper Publication Authors: Brasch, J., Harrison, O.J., Shapiro, L. Description: Category: Unreleased Structures [[Catego...

2016-05-11T00:50:48Z

New page: '''Unreleased structure''' The entry 5iry is ON HOLD until Paper Publication Authors: Brasch, J., Harrison, O.J., Shapiro, L. Description: Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 5iry is ON HOLD until Paper Publication

Authors: Brasch, J., Harrison, O.J., Shapiro, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Shapiro, L]]
[[Category: Harrison, O.J]]
[[Category: Brasch, J]]