5it2 - Revision history

OCA at 14:08, 30 August 2023

2023-08-30T14:08:25Z

← Older revision		Revision as of 14:08, 30 August 2023
Line 3:		Line 3:
	<StructureSection load='5it2' size='340' side='right'caption='[[5it2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5it2' size='340' side='right'caption='[[5it2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5it2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5it2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IT2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it2 OCA], [~~http~~://pdbe.org/5it2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5it2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5it2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5it2 ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it2 OCA], [https://pdbe.org/5it2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5it2 RCSB], [https://www.ebi.ac.uk/pdbsum/5it2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5it2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen X]]
	[[Category: Dalhus, B]]		[[Category: Dalhus B]]
	[[Category: Hnida, K]]		[[Category: Hnida K]]
	[[Category: Iversen, R]]		[[Category: Iversen R]]
	[[Category: Sollid~~, L M]]~~		[[Category: Sollid LM]]
	~~[[Category: Autoantibody]]~~
	~~[[Category: Fab fragment]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Transglutaminase 2~~]]

OCA at 07:30, 3 June 2020

2020-06-03T07:30:44Z

← Older revision		Revision as of 07:30, 3 June 2020
Line 1:		Line 1:

	==Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment==		==Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment==
	<StructureSection load='5it2' size='340' side='right' caption='[[5it2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5it2' size='340' side='right'caption='[[5it2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5it2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IT2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5it2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IT2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it2 OCA], [http://pdbe.org/5it2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5it2 RCSB], [http://www.ebi.ac.uk/pdbsum/5it2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5it2 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it2 OCA], [http://pdbe.org/5it2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5it2 RCSB], [http://www.ebi.ac.uk/pdbsum/5it2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5it2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Dalhus, B]]		[[Category: Dalhus, B]]

OCA at 16:14, 22 March 2017

2017-03-22T16:14:12Z

← Older revision		Revision as of 16:14, 22 March 2017
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5it2 is ~~ON HOLD until Paper~~ Publication		==Structure of a transglutaminase 2-specific autoantibody 693-10-B06 Fab fragment==
			<StructureSection load='5it2' size='340' side='right' caption='[[5it2]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5it2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IT2 FirstGlance]. <br>
			</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5it2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5it2 OCA], [http://pdbe.org/5it2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5it2 RCSB], [http://www.ebi.ac.uk/pdbsum/5it2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5it2 ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or HLA-DQ8 (ref. 3). We assessed in a comprehensive and nonbiased manner the IgA anti-TG2 response by expression cloning of the antibody repertoire of ex vivo-isolated intestinal antibody-secreting cells (ASCs). We found that TG2-specific plasma cells are markedly expanded within the duodenal mucosa in individuals with active celiac disease. TG2-specific antibodies were of high affinity yet showed little adaptation by somatic mutations. Unlike infection-induced peripheral blood plasmablasts, the TG2-specific ASCs had not recently proliferated and were not short-lived ex vivo. Altogether, these observations demonstrate that there is a germline repertoire with high affinity for TG2 that may favor massive generation of autoreactive B cells. TG2-specific antibodies did not block enzymatic activity and served as substrates for TG2-mediated crosslinking when expressed as IgD or IgM but not as IgA1 or IgG1. This could result in preferential recruitment of plasma cells from naive IgD- and IgM-expressing B cells, thus possibly explaining why the antibody response to TG2 bears signs of a primary immune response despite the disease chronicity.

	~~Authors: Chen~~, X., ~~Dalhus~~, B., ~~Hnida~~, K., Iversen, R., Sollid~~, L~~.M.		High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.,Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, Huang M, Iversen R, du Pre MF, Qiao SW, Lundin KE, Wilson PC, Sollid LM Nat Med. 2012 Feb 26;18(3):441-5. doi: 10.1038/nm.2656. PMID:22366952<ref>PMID:22366952</ref>

	~~Description: Structure~~ of ~~a transglutiminase 2~~-~~specific autoantibody 693~~-~~10-B06 Fab fragment~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[Category: Unreleased Structures]]~~		</div>
	~~[[Category: Sollid, L.M]]~~		<div class="pdbe-citations 5it2" style="background-color:#fffaf0;"></div>
	~~[[Category: Iversen, R]]~~		== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Chen, X]]		[[Category: Chen, X]]
			[[Category: Dalhus, B]]
	[[Category: Hnida, K]]		[[Category: Hnida, K]]
	[[Category: ~~Dalhus~~, B]]		[[Category: Iversen, R]]
			[[Category: Sollid, L M]]
			[[Category: Autoantibody]]
			[[Category: Fab fragment]]
			[[Category: Immune system]]
			[[Category: Transglutaminase 2]]

OCA at 09:40, 9 March 2017

2017-03-09T09:40:35Z

← Older revision		Revision as of 09:40, 9 March 2017
Line 7:		Line 7:
	Description: Structure of a transglutiminase 2-specific autoantibody 693-10-B06 Fab fragment		Description: Structure of a transglutiminase 2-specific autoantibody 693-10-B06 Fab fragment
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Sollid, L.M]]
	[[Category: Iversen, R]]		[[Category: Iversen, R]]
			[[Category: Chen, X]]
	[[Category: Hnida, K]]		[[Category: Hnida, K]]
	~~[[Category: Sollid, L.M]]~~
	~~[[Category: Chen, X]]~~
	[[Category: Dalhus, B]]		[[Category: Dalhus, B]]

OCA: Protected "5it2" [edit=sysop:move=sysop]

2016-05-11T00:53:08Z

Protected "5it2" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:53, 11 May 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5it2 is ON HOLD until Paper Publication Authors: Chen, X., Dalhus, B., Hnida, K., Iversen, R., Sollid, L.M. Description: Structure of a transglutim...

2016-05-11T00:53:07Z

New page: '''Unreleased structure''' The entry 5it2 is ON HOLD until Paper Publication Authors: Chen, X., Dalhus, B., Hnida, K., Iversen, R., Sollid, L.M. Description: Structure of a transglutim...

New page

'''Unreleased structure'''

The entry 5it2 is ON HOLD until Paper Publication

Authors: Chen, X., Dalhus, B., Hnida, K., Iversen, R., Sollid, L.M.

Description: Structure of a transglutiminase 2-specific autoantibody 693-10-B06 Fab fragment
[[Category: Unreleased Structures]]
[[Category: Iversen, R]]
[[Category: Hnida, K]]
[[Category: Sollid, L.M]]
[[Category: Chen, X]]
[[Category: Dalhus, B]]