5jun - Revision history

OCA at 19:08, 20 September 2023

2023-09-20T19:08:43Z

← Older revision		Revision as of 19:08, 20 September 2023
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	==PB2 bound to an azaindole inhibitor==		==PB2 bound to an azaindole inhibitor==
	<StructureSection load='5jun' size='340' side='right' caption='[[5jun]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='5jun' size='340' side='right'caption='[[5jun]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jun]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~I75a0 I75a0~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Beijing/39/1975(H3N2)) Influenza A virus (A/Beijing/39/1975(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JUN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6NU:(3~{R})-3-[[5-FLUORANYL-2-(5-FLUORANYL-1~{H}-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-4-YL]AMINO]-3-(1-METHYLCYCLOBUTYL)PROPANOIC+ACID'>6NU</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.69Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jur\|5jur]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6NU:(3~{R})-3-[[5-FLUORANYL-2-(5-FLUORANYL-1~{H}-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-4-YL]AMINO]-3-(1-METHYLCYCLOBUTYL)PROPANOIC+ACID'>6NU</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383596 I75A0])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jun OCA], [https://pdbe.org/5jun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jun RCSB], [https://www.ebi.ac.uk/pdbsum/5jun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jun ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jun OCA], [~~http~~://pdbe.org/5jun PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jun RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jun PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jun ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]		[https://www.uniprot.org/uniprot/PB2_I75A0 PB2_I75A0] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5jun" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jun" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~I75a0~~]]		[[Category: Large Structures]]
	[[Category: Jacobs~~, M D]]~~		[[Category: Jacobs MD]]
	~~[[Category: Flu]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Nucleotide binding]]~~
	~~[[Category: Polymerase]]~~
	~~[[Category: Rna binding protein~~]]

OCA at 10:03, 22 November 2017

2017-11-22T10:03:58Z

← Older revision		Revision as of 10:03, 22 November 2017
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	<StructureSection load='5jun' size='340' side='right' caption='[[5jun]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='5jun' size='340' side='right' caption='[[5jun]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jun]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUN FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jun]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/I75a0 I75a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JUN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6NU:(3~{R})-3-[[5-FLUORANYL-2-(5-FLUORANYL-1~{H}-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-4-YL]AMINO]-3-(1-METHYLCYCLOBUTYL)PROPANOIC+ACID'>6NU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6NU:(3~{R})-3-[[5-FLUORANYL-2-(5-FLUORANYL-1~{H}-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-4-YL]AMINO]-3-(1-METHYLCYCLOBUTYL)PROPANOIC+ACID'>6NU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jur\|5jur]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jur\|5jur]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383596 I75A0])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jun OCA], [http://pdbe.org/5jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jun RCSB], [http://www.ebi.ac.uk/pdbsum/5jun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jun ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jun OCA], [http://pdbe.org/5jun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jun RCSB], [http://www.ebi.ac.uk/pdbsum/5jun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jun ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: I75a0]]
	[[Category: Jacobs, M D]]		[[Category: Jacobs, M D]]
	[[Category: Flu]]		[[Category: Flu]]

OCA at 15:45, 17 May 2017

2017-05-17T15:45:05Z

@@ Line 1: / Line 1: @@
-The entry 5jun is ON HOLD  until Paper Publication
+==PB2 bound to an azaindole inhibitor==
-Authors: Jacobs, M.D.
+Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.,Farmer LJ, Clark MP, Boyd MJ, Perola E, Jones SM, Tsai A, Jacobs MD, Bandarage UK, Ledeboer MW, Wang T, Deng H, Ledford B, Gu W, Duffy JP, Bethiel RS, Shannon D, Byrn RA, Leeman JR, Rijnbrand R, Bennett HB, O'Brien C, Memmott C, Nti-Addae K, Bennani YL, Charifson PS ACS Med Chem Lett. 2017 Jan 20;8(2):256-260. doi: 10.1021/acsmedchemlett.6b00486., eCollection 2017 Feb 9. PMID:28197322<ref>PMID:28197322</ref>
-Description: PB2 bound to an azaindole inhibitor
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Jacobs, M.D]]
+<div class="pdbe-citations 5jun" style="background-color:#fffaf0;"></div>

OCA: Protected "5jun" [edit=sysop:move=sysop]

2016-06-01T13:51:21Z

Protected "5jun" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:51, 1 June 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5jun is ON HOLD until Paper Publication Authors: Jacobs, M.D. Description: PB2 bound to an azaindole inhibitor Category: Unreleased Structures ...

2016-06-01T13:51:20Z

New page: '''Unreleased structure''' The entry 5jun is ON HOLD until Paper Publication Authors: Jacobs, M.D. Description: PB2 bound to an azaindole inhibitor Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 5jun is ON HOLD until Paper Publication

Authors: Jacobs, M.D.

Description: PB2 bound to an azaindole inhibitor
[[Category: Unreleased Structures]]
[[Category: Jacobs, M.D]]