5m4e - Revision history

OCA at 18:25, 1 November 2023

2023-11-01T18:25:39Z

← Older revision		Revision as of 18:25, 1 November 2023
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	<StructureSection load='5m4e' size='340' side='right'caption='[[5m4e]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5m4e' size='340' side='right'caption='[[5m4e]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5m4e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5M4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5m4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F9:~{N}-[2-(ETHYLAMINO)-2-OXIDANYLIDENE-ETHYL]-~{N}-(4-METHOXYPHENYL)-2,4-BIS(OXIDANYL)BENZAMIDE'>7F9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F9:~{N}-[2-(ETHYLAMINO)-2-OXIDANYLIDENE-ETHYL]-~{N}-(4-METHOXYPHENYL)-2,4-BIS(OXIDANYL)BENZAMIDE'>7F9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4e OCA], [~~http~~://pdbe.org/5m4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4e OCA], [https://pdbe.org/5m4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m4e RCSB], [https://www.ebi.ac.uk/pdbsum/5m4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Baker~~, L M]]~~		[[Category: Baker LM]]
	~~[[Category: Cancer]]~~
	~~[[Category: Fragment screening]]~~
	~~[[Category: Hsp90]]~~
	~~[[Category: Kinase inhibitor]]~~
	~~[[Category: Off-rate screening]]~~
	~~[[Category: Pdhk]]~~
	~~[[Category: Pdk1]]~~
	~~[[Category: Pdk2]]~~
	~~[[Category: Pdk3]]~~
	~~[[Category: Pdk4]]~~
	~~[[Category: Spr]]~~
	~~[[Category: Transferase~~]]

OCA at 11:00, 12 August 2020

2020-08-12T11:00:57Z

← Older revision		Revision as of 11:00, 12 August 2020
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	==Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase==		==Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase==
	<StructureSection load='5m4e' size='340' side='right' caption='[[5m4e]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5m4e' size='340' side='right'caption='[[5m4e]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5m4e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5m4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7F9:~{N}-[2-(ETHYLAMINO)-2-OXIDANYLIDENE-ETHYL]-~{N}-(4-METHOXYPHENYL)-2,4-BIS(OXIDANYL)BENZAMIDE'>7F9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7F9:~{N}-[2-(ETHYLAMINO)-2-OXIDANYLIDENE-ETHYL]-~{N}-(4-METHOXYPHENYL)-2,4-BIS(OXIDANYL)BENZAMIDE'>7F9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4e OCA], [http://pdbe.org/5m4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4e RCSB], [http://www.ebi.ac.uk/pdbsum/5m4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4e ProSAT]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4e OCA], [http://pdbe.org/5m4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4e RCSB], [http://www.ebi.ac.uk/pdbsum/5m4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5m4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5m4e" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Baker, L M]]		[[Category: Baker, L M]]
	[[Category: Cancer]]		[[Category: Cancer]]

OCA at 01:37, 11 March 2017

2017-03-11T01:37:44Z

@@ Line 1: / Line 1: @@
-The entry 5m4e is ON HOLD
+==Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase==
-Authors: Baker, L.M.
+Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.,Brough PA, Baker L, Bedford S, Brown K, Chavda S, Chell V, D'Alessandro J, Davies NG, Davis B, Le Strat L, Macias AT, Maddox D, Mahon PC, Massey AJ, Matassova N, McKenna S, Moore JD, Murray JB, Northfield CJ, Parry C, Parsons R, Roughley SD, Shaw T, Simmonite H, Stokes S, Surgenor A, Stefaniak E, Robertson A, Wang Y, Webb P, Whitehead N, Wood M J Med Chem. 2017 Feb 15. doi: 10.1021/acs.jmedchem.6b01478. PMID:28199108<ref>PMID:28199108</ref>
-Description: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Baker, L.M]]
+<div class="pdbe-citations 5m4e" style="background-color:#fffaf0;"></div>

OCA: Protected "5m4e" [edit=sysop:move=sysop]

2016-10-26T16:23:49Z

Protected "5m4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:23, 26 October 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5m4e is ON HOLD Authors: Baker, L.M. Description: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruva...

2016-10-26T16:23:47Z

New page: '''Unreleased structure''' The entry 5m4e is ON HOLD Authors: Baker, L.M. Description: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruva...

New page

'''Unreleased structure'''

The entry 5m4e is ON HOLD

Authors: Baker, L.M.

Description: Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
[[Category: Unreleased Structures]]
[[Category: Baker, L.M]]