5mvb - Revision history

OCA at 06:02, 19 June 2024

2024-06-19T06:02:55Z

← Older revision		Revision as of 06:02, 19 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [https://pdbe.org/5mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [https://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [https://pdbe.org/5mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [https://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:18, 14 June 2023

2023-06-14T10:18:32Z

← Older revision		Revision as of 10:18, 14 June 2023
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	==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==		==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==
	<StructureSection load='5mvb' size='340' side='right'caption='[[5mvb~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='5mvb' size='340' side='right'caption='[[5mvb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [~~http~~://pdbe.org/5mvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [https://pdbe.org/5mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [https://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bazzicalupi, C]]		[[Category: Bazzicalupi C]]
	[[Category: Bendel~~, L E~~]]		[[Category: Bendel LE]]
	[[Category: Gratteri, P]]		[[Category: Gratteri P]]
	[[Category: Gruen, T]]		[[Category: Gruen T]]
	[[Category: Jonker~~, H R.A~~]]		[[Category: Jonker HRA]]
	[[Category: Messori, L]]		[[Category: Messori L]]
	[[Category: Schwalbe, H]]		[[Category: Schwalbe H]]
	[[Category: Wirmer-Bartoschek, J]]		[[Category: Wirmer-Bartoschek J]]
	~~[[Category: Auoxo6]]~~
	~~[[Category: Dna]]~~
	~~[[Category: G-quadruplex hybrid~~]]

OCA at 13:11, 10 May 2019

2019-05-10T13:11:39Z

← Older revision		Revision as of 13:11, 10 May 2019
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	==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==		==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==
	<StructureSection load='5mvb' size='340' side='right' caption='[[5mvb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='5mvb' size='340' side='right'caption='[[5mvb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MVB FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Bazzicalupi, C]]		[[Category: Bazzicalupi, C]]
	[[Category: Bendel, L E]]		[[Category: Bendel, L E]]

OCA at 08:10, 17 January 2018

2018-01-17T08:10:22Z

← Older revision		Revision as of 08:10, 17 January 2018
Line 1:		Line 1:

	==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand==		==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.==
	<StructureSection load='5mvb' size='340' side='right' caption='[[5mvb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='5mvb' size='340' side='right' caption='[[5mvb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 09:42, 3 August 2017

2017-08-03T09:42:56Z

← Older revision		Revision as of 09:42, 3 August 2017
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	The ~~entry 5mvb~~ is ~~ON HOLD~~		==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand==
			<StructureSection load='5mvb' size='340' side='right' caption='[[5mvb]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MVB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [http://pdbe.org/5mvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [http://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr>
			</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Telomeric G-quadruplexes have recently emerged as drug targets in cancer research. Herein, we present the first NMR structure of a telomeric DNA G-quadruplex that adopts the biologically relevant hybrid-2 conformation in a ligand-bound state. We solved the complex with a metalorganic gold(III) ligand that stabilizes G-quadruplexes. Analysis of the free and bound structures reveals structural changes in the capping region of the G-quadruplex. The ligand is sandwiched between one terminal G-tetrad and a flanking nucleotide. This complex structure involves a major structural rearrangement compared to the free G-quadruplex structure as observed for other G-quadruplexes in different conformations, invalidating simple docking approaches to ligand-G-quadruplex structure determination.

	~~Authors:~~ Wirmer-Bartoschek, J~~., Jonker, H.R.A.~~, Bendel, ~~L.E.~~, ~~Gruen~~, T., Bazzicalupi, C., Messori, L., Gratteri, P., Schwalbe, H.		Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.,Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grun JT, Papi F, Bazzicalupi C, Messori L, Gratteri P, Schwalbe H Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7102-7106. doi:, 10.1002/anie.201702135. Epub 2017 May 19. PMID:28524432<ref>PMID:28524432</ref>

	~~Description: Solution structure~~ of ~~a human G~~-~~Quadruplex hybrid~~-~~2 form in complex with a Gold-ligand~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	[[Category: ~~Unreleased Structures~~]]		</div>
	[[Category: ~~Wirmer-Bartoschek~~, J]]		<div class="pdbe-citations 5mvb" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Bazzicalupi, C]]
			[[Category: Bendel, L E]]
			[[Category: Gratteri, P]]
	[[Category: Gruen, T]]		[[Category: Gruen, T]]
			[[Category: Jonker, H R.A]]
	[[Category: Messori, L]]		[[Category: Messori, L]]
	~~[[Category: Jonker, H.R.A]]~~
	~~[[Category: Gratteri, P]]~~
	[[Category: Schwalbe, H]]		[[Category: Schwalbe, H]]
	[[Category: ~~Bazzicalupi~~, C]]		[[Category: Wirmer-Bartoschek, J]]
	[[Category: ~~Bendel, L.E~~]]		[[Category: Auoxo6]]
			[[Category: Dna]]
			[[Category: G-quadruplex hybrid]]

OCA at 11:41, 9 March 2017

2017-03-09T11:41:36Z

← Older revision		Revision as of 11:41, 9 March 2017
Line 10:		Line 10:
	[[Category: Gruen, T]]		[[Category: Gruen, T]]
	[[Category: Messori, L]]		[[Category: Messori, L]]
			[[Category: Jonker, H.R.A]]
	[[Category: Gratteri, P]]		[[Category: Gratteri, P]]
	~~[[Category: Bendel, L.E]]~~
	~~[[Category: Jonker, H.R.A]]~~
	[[Category: Schwalbe, H]]		[[Category: Schwalbe, H]]
	[[Category: Bazzicalupi, C]]		[[Category: Bazzicalupi, C]]
			[[Category: Bendel, L.E]]

OCA: Protected "5mvb" [edit=sysop:move=sysop]

2017-01-25T20:37:27Z

Protected "5mvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:37, 25 January 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5mvb is ON HOLD Authors: Wirmer-Bartoschek, J., Jonker, H.R.A., Bendel, L.E., Gruen, T., Bazzicalupi, C., Messori, L., Gratteri, P., Schwalbe, H. D...

2017-01-25T20:37:25Z

New page: '''Unreleased structure''' The entry 5mvb is ON HOLD Authors: Wirmer-Bartoschek, J., Jonker, H.R.A., Bendel, L.E., Gruen, T., Bazzicalupi, C., Messori, L., Gratteri, P., Schwalbe, H. D...

New page

'''Unreleased structure'''

The entry 5mvb is ON HOLD

Authors: Wirmer-Bartoschek, J., Jonker, H.R.A., Bendel, L.E., Gruen, T., Bazzicalupi, C., Messori, L., Gratteri, P., Schwalbe, H.

Description: Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand
[[Category: Unreleased Structures]]
[[Category: Wirmer-Bartoschek, J]]
[[Category: Gruen, T]]
[[Category: Messori, L]]
[[Category: Gratteri, P]]
[[Category: Bendel, L.E]]
[[Category: Jonker, H.R.A]]
[[Category: Schwalbe, H]]
[[Category: Bazzicalupi, C]]