5mxv - Revision history

OCA at 17:53, 8 November 2023

2023-11-08T17:53:22Z

← Older revision		Revision as of 17:53, 8 November 2023
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	<StructureSection load='5mxv' size='340' side='right'caption='[[5mxv]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='5mxv' size='340' side='right'caption='[[5mxv]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mxv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mxv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K3T:3-chloranyl-~{N}-(4,5-dihydro-1,3-thiazol-2-yl)-6-fluoranyl-1-benzothiophene-2-carboxamide'>K3T</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.626Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxv OCA], [~~http~~://pdbe.org/5mxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxv ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K3T:3-chloranyl-~{N}-(4,5-dihydro-1,3-thiazol-2-yl)-6-fluoranyl-1-benzothiophene-2-carboxamide'>K3T</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxv OCA], [https://pdbe.org/5mxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mxv RCSB], [https://www.ebi.ac.uk/pdbsum/5mxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>		[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5mxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5mxv" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blaszczyk, M]]		[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Blundell~~, T L~~]]		[[Category: Blaszczyk M]]
	[[Category: Mendes, V]]		[[Category: Blundell TL]]
	[[Category: Mugumbate, G]]		[[Category: Mendes V]]
	~~[[Category: Ethr]]~~		[[Category: Mugumbate G]]
	~~[[Category: Mycobacterium tuberculosis]]~~
	~~[[Category: Represor]]~~
	~~[[Category: Transcription~~]]

OCA at 07:31, 19 August 2020

2020-08-19T07:31:40Z

← Older revision		Revision as of 07:31, 19 August 2020
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	==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution==		==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution==
	<StructureSection load='5mxv' size='340' side='right' caption='[[5mxv]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='5mxv' size='340' side='right'caption='[[5mxv]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mxv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MXV FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mxv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MXV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K3T:3-chloranyl-~{N}-(4,5-dihydro-1,3-thiazol-2-yl)-6-fluoranyl-1-benzothiophene-2-carboxamide'>K3T</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K3T:3-chloranyl-~{N}-(4,5-dihydro-1,3-thiazol-2-yl)-6-fluoranyl-1-benzothiophene-2-carboxamide'>K3T</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxv OCA], [http://pdbe.org/5mxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxv RCSB], [http://www.ebi.ac.uk/pdbsum/5mxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mxv OCA], [http://pdbe.org/5mxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mxv RCSB], [http://www.ebi.ac.uk/pdbsum/5mxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mxv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Blaszczyk, M]]		[[Category: Blaszczyk, M]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]

OCA at 07:04, 25 October 2017

2017-10-25T07:04:24Z

@@ Line 1: / Line 1: @@
-The entry 5mxv is ON HOLD  until Paper Publication
+==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution==
-Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L.
+Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.,Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection, 2017. PMID:29018348<ref>PMID:29018348</ref>
-Description: Structure of Transcriptional Regulatory Repressor Protein -EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Blundell, T.L]]
+<div class="pdbe-citations 5mxv" style="background-color:#fffaf0;"></div>
 [[Category: Mendes, V]]
 [[Category: Mugumbate, G]]

OCA at 11:46, 9 March 2017

2017-03-09T11:46:03Z

← Older revision		Revision as of 11:46, 9 March 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5mxv is ON HOLD		The entry 5mxv is ON HOLD until Paper Publication

	Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L.		Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L.
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	Description: Structure of Transcriptional Regulatory Repressor Protein -EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution		Description: Structure of Transcriptional Regulatory Repressor Protein -EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Blaszczyk, M]]~~
	[[Category: Blundell, T.L]]		[[Category: Blundell, T.L]]
	[[Category: Mendes, V]]		[[Category: Mendes, V]]
			[[Category: Blaszczyk, M]]
	[[Category: Mugumbate, G]]		[[Category: Mugumbate, G]]

OCA: Protected "5mxv" [edit=sysop:move=sysop]

2017-02-01T15:22:33Z

Protected "5mxv" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:22, 1 February 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5mxv is ON HOLD Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L. Description: Structure of Transcriptional Regulatory Repressor Pr...

2017-02-01T15:22:31Z

New page: '''Unreleased structure''' The entry 5mxv is ON HOLD Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L. Description: Structure of Transcriptional Regulatory Repressor Pr...

New page

'''Unreleased structure'''

The entry 5mxv is ON HOLD

Authors: Blaszczyk, M., Mendes, V., Mugumbate, G., Blundell, T.L.

Description: Structure of Transcriptional Regulatory Repressor Protein -EthR from Mycobacterium Tuberculosis in complex with compound GSK1107112A at 1.63A resolution
[[Category: Unreleased Structures]]
[[Category: Blaszczyk, M]]
[[Category: Blundell, T.L]]
[[Category: Mendes, V]]
[[Category: Mugumbate, G]]