OCA at 12:14, 9 May 2024

2024-05-09T12:14:58Z

← Older revision		Revision as of 12:14, 9 May 2024
Line 22:		Line 22:
	==See Also==		==See Also==
	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]		*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
			*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:10, 29 November 2023

2023-11-29T19:10:22Z

← Older revision		Revision as of 19:10, 29 November 2023
Line 1:		Line 1:

	==Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin==		==Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin==
	<StructureSection load='5o7a' size='340' side='right' caption='[[5o7a]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5o7a' size='340' side='right'caption='[[5o7a]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5o7a]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5O7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[5o7a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O7A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9N5:(2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide'>9N5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.495Å</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Stmn4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), TTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9N5:(2~{R})-2-(3-ethynylquinolin-6-yl)oxy-2-methoxy-~{N}-[(1~{E})-1-methoxyimino-2-methyl-propan-2-yl]ethanamide'>9N5</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7a OCA], [~~http~~://pdbe.org/5o7a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5o7a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5o7a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7a OCA], [https://pdbe.org/5o7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o7a RCSB], [https://www.ebi.ac.uk/pdbsum/5o7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain ~~(By similarity)~~.		[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5o7a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5o7a" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: ~~Buffalo rat~~]]		[[Category: Gallus gallus]]
	[[Category: ~~Chick~~]]		[[Category: Large Structures]]
	[[Category: ~~Olieric, N~~]]		[[Category: Rattus norvegicus]]
	[[Category: ~~Sharma, A~~]]		[[Category: Olieric N]]
	[[Category: ~~Steinmetz, M O~~]]		[[Category: Sharma A]]
	[[Category: ~~Colchicine]]~~		[[Category: Steinmetz MO]]
	~~[[Category: Microtubule]]~~
	~~[[Category: Motor protein]]~~
	~~[[Category: Quinolin-6-yloxyacetamide]]~~
	~~[[Category: Tubulin~~]]

OCA: Protected "5o7a" [edit=sysop:move=sysop]

2017-11-16T06:35:03Z

Protected "5o7a" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:35, 16 November 2017
(No difference)

OCA: New page: ==Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin==

5o7a - Revision history

OCA at 12:14, 9 May 2024

OCA at 19:10, 29 November 2023

OCA: Protected "5o7a" [edit=sysop:move=sysop]

OCA: New page: ==Quinolin-6-yloxyacetamides are microtubule destabilizing agents that bind to the colchicine site of tubulin==