5o7e - Revision history

OCA at 19:10, 29 November 2023

2023-11-29T19:10:27Z

← Older revision		Revision as of 19:10, 29 November 2023
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	<StructureSection load='5o7e' size='340' side='right'caption='[[5o7e]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5o7e' size='340' side='right'caption='[[5o7e]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5o7e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_histolyticus"_weinberg_and_seguin_1916 "bacillus histolyticus" weinberg and seguin 1916~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5O7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5o7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hathewaya_histolytica Hathewaya histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O7E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NB:~{N}-(4-ethanoylphenyl)-2-sulfanyl-ethanamide'>9NB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arf\|4arf]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9NB:~{N}-(4-ethanoylphenyl)-2-sulfanyl-ethanamide'>9NB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1498 "Bacillus histolyticus" Weinberg and Seguin 1916])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7e OCA], [https://pdbe.org/5o7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o7e RCSB], [https://www.ebi.ac.uk/pdbsum/5o7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7e ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5o7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7e OCA], [~~http~~://pdbe.org/5o7e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5o7e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5o7e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7e ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/COLH_HATHI COLH_HATHI] Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization. Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen (PubMed:3002446). The full-length protein has collagenase activity, while both the 116 kDa and 98 kDa forms act on gelatin (PubMed:7961400). In vitro digestion of soluble calf skin collagen fibrils requires both ColG and ColH; ColG forms missing the second collagen-binding domain is also synergistic with ColH, although their overall efficiency is decreased (PubMed:18374061, PubMed:22099748). Digestion of collagen requires Ca(2+) and is inhibited by EDTA (PubMed:9452493). The activator domain (residues 119-388) and catalytic subdomain (330-601) open and close around substrate allowing digestion when the protein is closed (PubMed:23703618).<ref>PMID:18374061</ref> <ref>PMID:18937627</ref> <ref>PMID:22099748</ref> <ref>PMID:23703618</ref> <ref>PMID:24125730</ref> <ref>PMID:28820255</ref> <ref>PMID:3002446</ref> <ref>PMID:7961400</ref> <ref>PMID:9452493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Collagenase 3D structures\|Collagenase 3D structures]]		*[[Collagenase 3D structures\|Collagenase 3D structures]]
	*[[Transcription initiation factor\|Transcription initiation factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus histolyticus weinberg and seguin 1916~~]]		[[Category: Hathewaya histolytica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brandstetter, H]]		[[Category: Brandstetter H]]
	[[Category: Schoenauer, E]]		[[Category: Schoenauer E]]
	~~[[Category: Collagenase]]~~
	~~[[Category: Gluzincin]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-inhibitor complex]]~~
	~~[[Category: Metalloprotease~~]]

OCA at 06:52, 16 October 2019

2019-10-16T06:52:30Z

← Older revision		Revision as of 06:52, 16 October 2019
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	==Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor==		==Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor==
	<StructureSection load='5o7e' size='340' side='right' caption='[[5o7e]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='5o7e' size='340' side='right'caption='[[5o7e]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5o7e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5o7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_histolyticus"_weinberg_and_seguin_1916 "bacillus histolyticus" weinberg and seguin 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O7E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NB:~{N}-(4-ethanoylphenyl)-2-sulfanyl-ethanamide'>9NB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9NB:~{N}-(4-ethanoylphenyl)-2-sulfanyl-ethanamide'>9NB</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arf\|4arf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4arf\|4arf]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1498 "Bacillus histolyticus" Weinberg and Seguin 1916])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7e OCA], [http://pdbe.org/5o7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o7e RCSB], [http://www.ebi.ac.uk/pdbsum/5o7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7e OCA], [http://pdbe.org/5o7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o7e RCSB], [http://www.ebi.ac.uk/pdbsum/5o7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7e ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 5o7e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5o7e" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Collagenase 3D structures\|Collagenase 3D structures]]
			*[[Transcription initiation factor\|Transcription initiation factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus histolyticus weinberg and seguin 1916]]
			[[Category: Large Structures]]
	[[Category: Brandstetter, H]]		[[Category: Brandstetter, H]]
	[[Category: Schoenauer, E]]		[[Category: Schoenauer, E]]

OCA at 05:50, 31 January 2018

2018-01-31T05:50:10Z

@@ Line 1: / Line 1: @@
-The entry 5o7e is ON HOLD  until Paper Publication
+==Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl mercaptoacetamide-based inhibitor==
-Authors:
+Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.,Schonauer E, Kany AM, Haupenthal J, Husecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsasser B, Ducho C, Brandstetter H, Hartmann RW J Am Chem Soc. 2017 Sep 13;139(36):12696-12703. doi: 10.1021/jacs.7b06935. Epub, 2017 Aug 31. PMID:28820255<ref>PMID:28820255</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "5o7e" [edit=sysop:move=sysop]

2017-09-27T12:06:46Z

Protected "5o7e" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:06, 27 September 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5o7e is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T12:06:45Z

New page: '''Unreleased structure''' The entry 5o7e is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5o7e is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]