5omp - Revision history

OCA at 16:54, 13 December 2023

2023-12-13T16:54:51Z

← Older revision		Revision as of 16:54, 13 December 2023
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	==Human FKBP5 protein==		==Human FKBP5 protein==
	<StructureSection load='5omp' size='340' side='right' caption='[[5omp]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='5omp' size='340' side='right'caption='[[5omp]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5omp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5omp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OMP FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[5njx\|5njx~~]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FKBP5, AIG6, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omp OCA], [https://pdbe.org/5omp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5omp RCSB], [https://www.ebi.ac.uk/pdbsum/5omp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5omp ProSAT]</span></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omp OCA], [~~http~~://pdbe.org/5omp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5omp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5omp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5omp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.		[https://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5omp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5omp" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[FKBP 3D structures\|FKBP 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Peptidylprolyl isomerase~~]]		[[Category: Large Structures]]
	[[Category: Kumar, R]]		[[Category: Kumar R]]
	[[Category: Moche, M]]		[[Category: Moche M]]
	[[Category: Pavlov, P]]		[[Category: Pavlov P]]
	[[Category: Winblad, B]]		[[Category: Winblad B]]
	~~[[Category: Fk506 binding protein]]~~
	~~[[Category: Fkbp51]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Tpr~~]]

OCA at 10:09, 22 November 2017

2017-11-22T10:09:42Z

← Older revision		Revision as of 10:09, 22 November 2017
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	<StructureSection load='5omp' size='340' side='right' caption='[[5omp]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='5omp' size='340' side='right' caption='[[5omp]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5omp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OMP FirstGlance]. <br>		<table><tr><td colspan='2'>[[5omp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OMP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5njx\|5njx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5njx\|5njx]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP5, AIG6, FKBP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omp OCA], [http://pdbe.org/5omp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5omp RCSB], [http://www.ebi.ac.uk/pdbsum/5omp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5omp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omp OCA], [http://pdbe.org/5omp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5omp RCSB], [http://www.ebi.ac.uk/pdbsum/5omp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5omp ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.		[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity. It is known for its role in various regulatory pathways implicated in mood and stress-related disorders, cancer, obesity, Alzheimer's disease and corticosteroid resistant asthma. It consists of two FKBP12 like active peptidyl prolyl isomerase (PPIase) domains (an active FK1 and inactive FK2 domain) and one tetratricopeptide repeat (TPR) domain that mediates interaction with Hsp90 via its C-terminal MEEVD peptide. Here, we report a combined x-ray crystallography and molecular dynamics study to reveal the binding mechanism of Hsp90 MEEVD peptide to the TPR domain of FKBP51. The results demonstrated that the Hsp90 C-terminal peptide binds to the TPR domain of FKBP51 with the help of di-carboxylate clamp involving Lys272, Glu273, Lys352, Asn322, and Lys329 which are conserved throughout several di-carboxylate clamp TPR proteins. Interestingly, the results from molecular dynamics study are also in agreement to the complex structure where all the contacts between these two partners were consistent throughout the simulation period. In a nutshell, our findings provide new opportunity to engage this important protein-protein interaction target by small molecules designed by structure based drug design strategy.

			Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.,Kumar R, Moche M, Winblad B, Pavlov PF Sci Rep. 2017 Oct 27;7(1):14288. doi: 10.1038/s41598-017-14731-z. PMID:29079741<ref>PMID:29079741</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5omp" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Kumar, R]]		[[Category: Kumar, R]]

OCA at 07:48, 8 November 2017

2017-11-08T07:48:42Z

← Older revision		Revision as of 07:48, 8 November 2017
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	~~'''Unreleased structure'''~~

	~~The entry~~ 5omp is ~~ON HOLD until Paper Publication~~		==Human FKBP5 protein==
			<StructureSection load='5omp' size='340' side='right' caption='[[5omp]], [[Resolution\|resolution]] 1.88Å' scene=''>
	~~Authors~~: ~~Kumar~~, R., ~~Moche~~, M., ~~Winblad~~, B., ~~Pavlov, P~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5omp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OMP FirstGlance]. <br>
	~~Description~~: ~~Human FKBP5 protein~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5njx\|5njx]]</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5omp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5omp OCA], [http://pdbe.org/5omp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5omp RCSB], [http://www.ebi.ac.uk/pdbsum/5omp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5omp ProSAT]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/FKBP5_HUMAN FKBP5_HUMAN]] Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
			__TOC__
			</StructureSection>
			[[Category: Peptidylprolyl isomerase]]
	[[Category: Kumar, R]]		[[Category: Kumar, R]]
			[[Category: Moche, M]]
	[[Category: Pavlov, P]]		[[Category: Pavlov, P]]
	[[Category: Winblad, B]]		[[Category: Winblad, B]]
	[[Category: ~~Moche, M~~]]		[[Category: Fk506 binding protein]]
			[[Category: Fkbp51]]
			[[Category: Isomerase]]
			[[Category: Tpr]]

OCA: Protected "5omp" [edit=sysop:move=sysop]

2017-09-27T12:36:03Z

Protected "5omp" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:36, 27 September 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5omp is ON HOLD until Paper Publication Authors: Kumar, R., Moche, M., Winblad, B., Pavlov, P. Description: Human FKBP5 protein [[Category: Unrelea...

2017-09-27T12:36:01Z

New page: '''Unreleased structure''' The entry 5omp is ON HOLD until Paper Publication Authors: Kumar, R., Moche, M., Winblad, B., Pavlov, P. Description: Human FKBP5 protein [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 5omp is ON HOLD until Paper Publication

Authors: Kumar, R., Moche, M., Winblad, B., Pavlov, P.

Description: Human FKBP5 protein
[[Category: Unreleased Structures]]
[[Category: Kumar, R]]
[[Category: Pavlov, P]]
[[Category: Winblad, B]]
[[Category: Moche, M]]