5qrf - Revision history

OCA at 12:46, 18 February 2026

2026-02-18T12:46:27Z

← Older revision		Revision as of 12:46, 18 February 2026
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	<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QRF FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:N-(1-~~ethyl-1H-pyrazol~~-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:~{N}-(1-ethylpyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [https://pdbe.org/5qrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [https://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [https://pdbe.org/5qrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [https://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:25, 21 February 2024

2024-02-21T11:25:30Z

← Older revision		Revision as of 11:25, 21 February 2024
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	<StructureSection load='5qrf' size='340' side='right'caption='[[5qrf]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5qrf' size='340' side='right'caption='[[5qrf]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QRF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CD:CADMIUM+ION'>CD</scene~~>, ~~<scene name='pdbligand=NUA:N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TBXT, T ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [~~http~~://pdbe.org/5qrf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [https://pdbe.org/5qrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [https://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]		[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]

			==See Also==
			*[[Brachyury\|Brachyury]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith~~, C H~~]]		[[Category: Arrowsmith CH]]
	[[Category: Bountra, C]]		[[Category: Bountra C]]
	[[Category: Burgess-Brown~~, N A]]~~		[[Category: Burgess-Brown NA]]
	~~[[Category: Delft, F von~~]]		[[Category: Edwards A]]
	[[Category: Edwards, A]]		[[Category: Fernandez-Cid A]]
	[[Category: Fernandez-Cid, A]]		[[Category: Gavard AE]]
	[[Category: Gavard~~, A E~~]]		[[Category: Gileadi O]]
	[[Category: Gileadi, O]]		[[Category: Newman JA]]
	[[Category: Newman~~, J A~~]]		[[Category: Sherestha L]]
	[[Category: Sherestha, L]]		[[Category: Von Delft F]]
	[[Category: ~~Pandda]]~~
	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~
	~~[[Category: Transcription]]~~
	~~[[Category: Xchemexplorer~~]]

OCA at 06:08, 7 August 2019

2019-08-07T06:08:58Z

← Older revision		Revision as of 06:08, 7 August 2019
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	<StructureSection load='5qrf' size='340' side='right'caption='[[5qrf]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5qrf' size='340' side='right'caption='[[5qrf]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TBXT, T ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [http://pdbe.org/5qrf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [http://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [http://pdbe.org/5qrf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [http://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 05:36, 10 July 2019

2019-07-10T05:36:02Z

← Older revision		Revision as of 05:36, 10 July 2019
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5qrf ~~is ON HOLD~~		==PanDDA analysis group deposition -- Crystal Structure of human Brachyury in complex with Z373768900==
			<StructureSection load='5qrf' size='340' side='right'caption='[[5qrf]], [[Resolution\|resolution]] 2.03Å' scene=''>
	~~Authors~~: ~~Newman, J~~.A.~~, Gavard, A~~.E., ~~Fernandez~~-~~Cid, A~~.~~, Sherestha, L~~.~~, Burgess~~-~~Brown~~, N.A., ~~von Delft~~, F., ~~Arrowsmith, C~~.H.~~, Edwards, A~~., ~~Bountra, C~~.~~, Gileadi, O~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5qrf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QRF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QRF FirstGlance]. <br>
	~~Description~~: ~~PanDDA analysis group deposition~~ --~~Crystal Structure~~ of ~~human Brachyury~~ in ~~complex with Z373768900~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NUA:N-(1-ethyl-1H-pyrazol-4-yl)cyclobutanecarboxamide'>NUA</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qrf OCA], [http://pdbe.org/5qrf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qrf RCSB], [http://www.ebi.ac.uk/pdbsum/5qrf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qrf ProSAT]</span></td></tr>
	[[Category: ~~Sherestha~~, L]]		</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Arrowsmith, C H]]
			[[Category: Bountra, C]]
			[[Category: Burgess-Brown, N A]]
			[[Category: Delft, F von]]
			[[Category: Edwards, A]]
	[[Category: Fernandez-Cid, A]]		[[Category: Fernandez-Cid, A]]
	[[Category: ~~Arrowsmith~~, ~~C.H~~]]		[[Category: Gavard, A E]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]
	[[Category: Newman, J.A]]		[[Category: Newman, J A]]
	[[Category: ~~Edwards~~, A]]		[[Category: Sherestha, L]]
	[[Category: ~~Burgess-Brown, N.A~~]]		[[Category: Pandda]]
	[[Category: ~~Gavard, A.E~~]]		[[Category: Sgc - diamond i04-1 fragment screening]]
	[[Category: ~~Von Delft, F~~]]		[[Category: Transcription]]
	[[Category: ~~Bountra, C~~]]		[[Category: Xchemexplorer]]

OCA at 04:56, 26 June 2019

2019-06-26T04:56:17Z

← Older revision		Revision as of 04:56, 26 June 2019
Line 3:		Line 3:
	The entry 5qrf is ON HOLD		The entry 5qrf is ON HOLD

	Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.		Authors: Newman, J.A., Gavard, A.E., Fernandez-Cid, A., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

	Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury in complex with Z373768900		Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury in complex with Z373768900
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Sherestha, L]]		[[Category: Sherestha, L]]
			[[Category: Fernandez-Cid, A]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Gileadi, O]]		[[Category: Gileadi, O]]

OCA: Protected "5qrf" [edit=sysop:move=sysop]

2019-06-05T20:48:49Z

Protected "5qrf" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:48, 5 June 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5qrf is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

2019-06-05T20:48:47Z

New page: '''Unreleased structure''' The entry 5qrf is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

New page

'''Unreleased structure'''

The entry 5qrf is ON HOLD

Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury in complex with Z373768900
[[Category: Unreleased Structures]]
[[Category: Sherestha, L]]
[[Category: Arrowsmith, C.H]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Burgess-Brown, N.A]]
[[Category: Gavard, A.E]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]