5t4e - Revision history

OCA at 12:54, 4 October 2023

2023-10-04T12:54:19Z

← Older revision		Revision as of 12:54, 4 October 2023
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	<StructureSection load='5t4e' size='340' side='right'caption='[[5t4e]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='5t4e' size='340' side='right'caption='[[5t4e]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5t4e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5T4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5t4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=75L:2-[(3R)-3-AMINOPIPERIDIN-1-YL]-3-(BUT-2-YN-1-YL)-6-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-6,7,8,9-TETRAHYDROPYRIMIDO[2,1-B]PURIN-4(3H)-ONE'>75L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.77Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t4h\|5t4h]], [[5t4b\|5t4b]], [[5t4f\|5t4f]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=75L:2-[(3R)-3-AMINOPIPERIDIN-1-YL]-3-(BUT-2-YN-1-YL)-6-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-6,7,8,9-TETRAHYDROPYRIMIDO[2,1-B]PURIN-4(3H)-ONE'>75L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4e OCA], [https://pdbe.org/5t4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t4e RCSB], [https://www.ebi.ac.uk/pdbsum/5t4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4e ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4e OCA], [~~http~~://pdbe.org/5t4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5t4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5t4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>		[https://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Dipeptidyl-peptidase IV]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Scapin, G]]		[[Category: Scapin G]]
	~~[[Category: Diabetes]]~~
	~~[[Category: Dpp4 inhibitor]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Structure-based drug design~~]]

OCA at 11:21, 16 September 2020

2020-09-16T11:21:08Z

← Older revision		Revision as of 11:21, 16 September 2020
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	==Human DPP4 in complex with ligand 19a==		==Human DPP4 in complex with ligand 19a==
	<StructureSection load='5t4e' size='340' side='right' caption='[[5t4e]], [[Resolution\|resolution]] 1.77Å' scene=''>		<StructureSection load='5t4e' size='340' side='right'caption='[[5t4e]], [[Resolution\|resolution]] 1.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5t4e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5T4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[5t4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=75L:2-[(3R)-3-AMINOPIPERIDIN-1-YL]-3-(BUT-2-YN-1-YL)-6-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-6,7,8,9-TETRAHYDROPYRIMIDO[2,1-B]PURIN-4(3H)-ONE'>75L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=75L:2-[(3R)-3-AMINOPIPERIDIN-1-YL]-3-(BUT-2-YN-1-YL)-6-[(4-METHYLQUINAZOLIN-2-YL)METHYL]-6,7,8,9-TETRAHYDROPYRIMIDO[2,1-B]PURIN-4(3H)-ONE'>75L</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t4h\|5t4h]], [[5t4b\|5t4b]], [[5t4f\|5t4f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5t4h\|5t4h]], [[5t4b\|5t4b]], [[5t4f\|5t4f]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4e OCA], [http://pdbe.org/5t4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t4e RCSB], [http://www.ebi.ac.uk/pdbsum/5t4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4e OCA], [http://pdbe.org/5t4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t4e RCSB], [http://www.ebi.ac.uk/pdbsum/5t4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5t4e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5t4e" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Scapin, G]]		[[Category: Scapin, G]]
	[[Category: Diabetes]]		[[Category: Diabetes]]

OCA at 21:46, 5 October 2016

2016-10-05T21:46:02Z

@@ Line 1: / Line 1: @@
-The entry 5t4e is ON HOLD  until Paper Publication
+==Human DPP4 in complex with ligand 19a==
-Authors: Scapin, G.
+Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.,Pissarnitski DA, Zhao Z, Cole D, Wu WL, Domalski M, Clader JW, Scapin G, Voigt J, Soriano A, Kelly T, Powles MA, Yao Z, Burnett DA Bioorg Med Chem. 2016 Sep 4. pii: S0968-0896(16)30694-0. doi:, 10.1016/j.bmc.2016.09.007. PMID:27670099<ref>PMID:27670099</ref>
-Description: Human DPP4 in complex with ligand 19a
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Scapin, G]]

OCA at 13:59, 14 September 2016

2016-09-14T13:59:30Z

← Older revision		Revision as of 13:59, 14 September 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5t4e is ON HOLD		The entry 5t4e is ON HOLD until Paper Publication

	Authors: Scapin, G.		Authors: Scapin, G.

OCA: Protected "5t4e" [edit=sysop:move=sysop]

2016-09-09T15:41:39Z

Protected "5t4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:41, 9 September 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5t4e is ON HOLD Authors: Scapin, G. Description: Human DPP4 in complex with ligand 19a Category: Unreleased Structures Category: Scapin, G

2016-09-09T15:41:38Z

New page: '''Unreleased structure''' The entry 5t4e is ON HOLD Authors: Scapin, G. Description: Human DPP4 in complex with ligand 19a Category: Unreleased Structures Category: Scapin, G

New page

'''Unreleased structure'''

The entry 5t4e is ON HOLD

Authors: Scapin, G.

Description: Human DPP4 in complex with ligand 19a
[[Category: Unreleased Structures]]
[[Category: Scapin, G]]