5tc7 - Revision history

OCA at 12:57, 4 October 2023

2023-10-04T12:57:39Z

← Older revision		Revision as of 12:57, 4 October 2023
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	<StructureSection load='5tc7' size='340' side='right'caption='[[5tc7]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='5tc7' size='340' side='right'caption='[[5tc7]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tc7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TC7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TC7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MTH:2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL'>MTH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.75Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[3oze\|3oze]], [[1k27\|1k27]], [[5tc8\|5tc8]], [[5tc6\|5tc6]], [[5tc5\|5tc5]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MTH:2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL'>MTH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTAP, MSAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc7 OCA], [https://pdbe.org/5tc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tc7 RCSB], [https://www.ebi.ac.uk/pdbsum/5tc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc7 ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc7 OCA], [~~http~~://pdbe.org/5tc7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tc7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tc7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc7 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[~~http~~://omim.org/entry/112250 112250]]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]		[https://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[https://omim.org/entry/112250 112250]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>		[https://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: S-methyl-5'-thioadenosine phosphorylase]]~~		[[Category: Almo SC]]
	[[Category: Almo~~, S C~~]]		[[Category: Cameron SA]]
	[[Category: Cameron~~, S A~~]]		[[Category: Firestone RS]]
	[[Category: Firestone~~, R S~~]]		[[Category: Schramm VL]]
	[[Category: Schramm~~, V L]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Phosphorylase]]~~
	~~[[Category: Transferase-transferase inhibitor complex~~]]

OCA at 09:23, 4 December 2019

2019-12-04T09:23:36Z

← Older revision		Revision as of 09:23, 4 December 2019
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	~~'''Unreleased structure'''~~

	The ~~entry 5tc7~~ is ~~ON HOLD~~ ~~until Paper Publication~~		==Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom==
			<StructureSection load='5tc7' size='340' side='right'caption='[[5tc7]], [[Resolution\|resolution]] 1.75Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[5tc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TC7 FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MTH:2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL'>MTH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
			<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[3oze\|3oze]], [[1k27\|1k27]], [[5tc8\|5tc8]], [[5tc6\|5tc6]], [[5tc5\|5tc5]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTAP, MSAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc7 OCA], [http://pdbe.org/5tc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tc7 RCSB], [http://www.ebi.ac.uk/pdbsum/5tc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc7 ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[http://omim.org/entry/112250 112250]]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]
			== Function ==
			[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>

	~~Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.~~		==See Also==
			*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures\|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]
	~~Description: Crystal structure of human~~ 5'-deoxy-5'-methylthioadenosine phosphorylase ~~in complex with~~ 5'-~~methylthiotubercidin at 1.75 angstrom~~		== References ==
	[[Category: ~~Unreleased~~ Structures]]		<references/>
	[[Category: ~~Almo,~~ S.C]]		__TOC__
	[[Category: ~~Schramm~~, ~~V.L~~]]		</StructureSection>
	[[Category: Cameron, S.A]]		[[Category: Human]]
	[[Category: Firestone, R.S]]		[[Category: Large Structures]]
			[[Category: S-methyl-5'-thioadenosine phosphorylase]]
			[[Category: Almo, S C]]
			[[Category: Cameron, S A]]
			[[Category: Firestone, R S]]
			[[Category: Schramm, V L]]
			[[Category: Inhibitor]]
			[[Category: Phosphorylase]]
			[[Category: Transferase-transferase inhibitor complex]]

OCA at 19:54, 5 October 2016

2016-10-05T19:54:18Z

← Older revision		Revision as of 19:54, 5 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5tc7 is ON HOLD		The entry 5tc7 is ON HOLD until Paper Publication

	Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.		Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.

OCA: Protected "5tc7" [edit=sysop:move=sysop]

2016-09-21T12:29:51Z

Protected "5tc7" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:29, 21 September 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5tc7 is ON HOLD Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C. Description: Crystal structure of human 5'-deoxy-5'-methylthioad...

2016-09-21T12:29:50Z

New page: '''Unreleased structure''' The entry 5tc7 is ON HOLD Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C. Description: Crystal structure of human 5'-deoxy-5'-methylthioad...

New page

'''Unreleased structure'''

The entry 5tc7 is ON HOLD

Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.

Description: Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 5'-methylthiotubercidin at 1.75 angstrom
[[Category: Unreleased Structures]]
[[Category: Almo, S.C]]
[[Category: Schramm, V.L]]
[[Category: Cameron, S.A]]
[[Category: Firestone, R.S]]