5thy - Revision history

OCA at 12:12, 6 November 2024

2024-11-06T12:12:07Z

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 == Function ==
 [https://www.uniprot.org/uniprot/F4Y426_9CYAN F4Y426_9CYAN]
 __TOC__
 </StructureSection>

OCA at 15:41, 6 March 2024

2024-03-06T15:41:06Z

← Older revision		Revision as of 15:41, 6 March 2024
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	<StructureSection load='5thy' size='340' side='right'caption='[[5thy]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='5thy' size='340' side='right'caption='[[5thy]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5thy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lyngbya_majuscula_3l Lyngbya majuscula 3l~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5THY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5thy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorena_producens_3L Moorena producens 3L]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5THY FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene~~>, ~~<scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.087Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class="sblockDat">[[5thz\|5thz]]</td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [https://pdbe.org/5thy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [https://www.ebi.ac.uk/pdbsum/5thy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</span></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LYNGBM3L_74460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=489825 Lyngbya majuscula 3L])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [~~http~~://pdbe.org/5thy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5thy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed~~ ==		[https://www.uniprot.org/uniprot/F4Y426_9CYAN F4Y426_9CYAN]
	Polyketide metabolites produced by modular type I polyketide synthases (PKS) acquire their chemical diversity through the variety of catalytic domains within modules of the pathway. Methyltransferases are among the least characterized of the catalytic domains common to PKS systems. We determined the domain boundaries and characterized the activity of a PKS C-methyltransferase (C-MT) from the curacin A biosynthetic pathway. The C-MT catalyzes S-adenosylmethionine-dependent methyl transfer to the alpha-position of beta-ketoacyl substrates linked to acyl carrier protein (ACP) or a small-molecule analog, but does not act on beta-hydroxyacyl substrates or malonyl-ACP. Key catalytic residues conserved in both bacterial and fungal PKS C-MTs were identified in a 2-A crystal structure and validated biochemically. Analysis of the structure and the sequences bordering the C-MT provides insight into the positioning of this domain within complete PKS modules.

	Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.,Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL ACS Chem Biol. 2016 Oct 10. PMID:27723289<ref>PMID:~~27723289<~~/~~ref>~~

	~~From MEDLINE®~~/~~PubMed®, a database of the U.S~~. ~~National Library of Medicine~~.~~<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 5thy" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references~~/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lyngbya majuscula 3l~~]]		[[Category: Moorena producens 3L]]
	[[Category: Skiba~~, M A~~]]		[[Category: Skiba MA]]
	[[Category: Smith~~, J L]]~~		[[Category: Smith JL]]
	~~[[Category: Lyase]]~~
	~~[[Category: Methyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 09:24, 4 December 2019

2019-12-04T09:24:03Z

← Older revision		Revision as of 09:24, 4 December 2019
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	==Crystal structure of SeMet-Substituted CurJ carbon methyltransferase==		==Crystal structure of SeMet-Substituted CurJ carbon methyltransferase==
	<StructureSection load='5thy' size='340' side='right' caption='[[5thy]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='5thy' size='340' side='right'caption='[[5thy]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5thy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5THY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5thy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lyngbya_majuscula_3l Lyngbya majuscula 3l]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5THY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5thz\|5thz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5thz\|5thz]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LYNGBM3L_74460 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=489825 Lyngbya majuscula 3L])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [http://pdbe.org/5thy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [http://www.ebi.ac.uk/pdbsum/5thy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [http://pdbe.org/5thy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [http://www.ebi.ac.uk/pdbsum/5thy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Lyngbya majuscula 3l]]
	[[Category: Skiba, M A]]		[[Category: Skiba, M A]]
	[[Category: Smith, J L]]		[[Category: Smith, J L]]

OCA at 11:26, 26 October 2016

2016-10-26T11:26:53Z

@@ Line 9: / Line 9: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [http://pdbe.org/5thy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [http://www.ebi.ac.uk/pdbsum/5thy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</span></td></tr>
 </table>
 __TOC__
 </StructureSection>

OCA: Protected "5thy" [edit=sysop:move=sysop]

2016-10-20T01:04:33Z

Protected "5thy" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:04, 20 October 2016
(No difference)

OCA: New page: ==Crystal structure of SeMet-Substituted CurJ carbon methyltransferase==
2016-10-20T01:04:29Z

New page: ==Crystal structure of SeMet-Substituted CurJ carbon methyltransferase== <StructureSection load='5thy' size='340' side='right' caption='5thy, resolution 2.09Å' sc...

New page

==Crystal structure of SeMet-Substituted CurJ carbon methyltransferase==
<StructureSection load='5thy' size='340' side='right' caption='[[5thy]], [[Resolution|resolution]] 2.09Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5thy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5THY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5THY FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5thz|5thz]]</td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5thy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5thy OCA], [http://pdbe.org/5thy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5thy RCSB], [http://www.ebi.ac.uk/pdbsum/5thy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5thy ProSAT]</td></tr>
</table>
TOC
</StructureSection>
[[Category: Skiba, M A]]
[[Category: Smith, J L]]
[[Category: Lyase]]
[[Category: Methyltransferase]]
[[Category: Transferase]]