5try - Revision history

OCA at 13:09, 4 October 2023

2023-10-04T13:09:51Z

← Older revision		Revision as of 13:09, 4 October 2023
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	<StructureSection load='5try' size='340' side='right'caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5try' size='340' side='right'caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TRY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.000008Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5trg\|5trg]], [[5trr\|5trr]], [[5trs\|5trs]], [[5ts0\|5ts0]]</td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prcA, MRA_2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), prcB, MRA_2125 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [https://pdbe.org/5try PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [https://www.ebi.ac.uk/pdbsum/5try PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [~~http~~://pdbe.org/5try PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5try PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/~~PSA_MYCTA PSA_MYCTA]~~] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. ~~[[http://www~~.~~uniprot~~.~~org/uniprot/PSB_MYCTA PSB_MYCTA]] Component~~ of the proteasome core~~, a large protease complex with broad specificity involved~~ in ~~protein~~ degradation.		[https://www.uniprot.org/uniprot/PSA_MYCTU PSA_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Proteasome endopeptidase complex]]~~
	~~[[Category: Fan, H]]~~
	~~[[Category: Hsu, H C]]~~
	~~[[Category: Li, H]]~~
	~~[[Category: Lin, G]]~~
	~~[[Category: Nathan, C]]~~
	~~[[Category: Singh, P K]]~~
	~~[[Category: Sukenick, G]]~~
	~~[[Category: Wang, R]]~~
	~~[[Category: C-capped dipeptide]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Inhibitor]]~~
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: ~~Proteasome~~]]		[[Category: Fan H]]
			[[Category: Hsu H-C]]
			[[Category: Li H]]
			[[Category: Lin G]]
			[[Category: Nathan C]]
			[[Category: Singh PK]]
			[[Category: Sukenick G]]
			[[Category: Wang R]]

OCA at 16:58, 11 December 2019

2019-12-11T16:58:37Z

← Older revision		Revision as of 16:58, 11 December 2019
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	==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206==		==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206==
	<StructureSection load='5try' size='340' side='right' caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5try' size='340' side='right'caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRY FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5try" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5try" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Proteasome 3D structures\|Proteasome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Proteasome endopeptidase complex]]		[[Category: Proteasome endopeptidase complex]]
	[[Category: Fan, H]]		[[Category: Fan, H]]

OCA at 14:26, 6 November 2017

2017-11-06T14:26:59Z

← Older revision		Revision as of 14:26, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='5try' size='340' side='right' caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5try' size='340' side='right' caption='[[5try]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5try]] is a 28 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5try]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7J0:(2~{S})-~{N}-[(2~{S})-3-METHOXY-1-(NAPHTHALEN-1-YLMETHYLAMINO)-1-OXIDANYLIDENE-PROPAN-2-YL]-4-OXIDANYLIDENE-2-(3-PHENYLPROPANOYLAMINO)-4-PIPERIDIN-1-YL-BUTANAMIDE'>7J0</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5trg\|5trg]], [[5trr\|5trr]], [[5trs\|5trs]], [[5ts0\|5ts0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5trg\|5trg]], [[5trr\|5trr]], [[5trs\|5trs]], [[5ts0\|5ts0]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">prcA, MRA_2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), prcB, MRA_2125 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [http://pdbe.org/5try PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [http://www.ebi.ac.uk/pdbsum/5try PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5try OCA], [http://pdbe.org/5try PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5try RCSB], [http://www.ebi.ac.uk/pdbsum/5try PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5try ProSAT]</span></td></tr>

OCA at 07:55, 18 January 2017

2017-01-18T07:55:30Z

@@ Line 1: / Line 1: @@
-The entry 5try is ON HOLD  until Paper Publication
+==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206==
-Authors: Hsu, H.-C., Fan, H., Singh, P.K., Wang, R., Sukenick, G., Nathan, C., Lin, G., Li, H.
+Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.,Hsu HC, Singh PK, Fan H, Wang R, Sukenick G, Nathan C, Lin G, Li H Biochemistry. 2017 Jan 10;56(1):324-333. doi: 10.1021/acs.biochem.6b01107. Epub, 2016 Dec 27. PMID:27976853<ref>PMID:27976853</ref>
-Description: Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Sukenick, G]]
 [[Category: Wang, R]]

OCA at 17:47, 9 December 2016

2016-12-09T17:47:24Z

← Older revision		Revision as of 17:47, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5try is ON HOLD		The entry 5try is ON HOLD until Paper Publication

	Authors: ~~Hao~~-~~Chi Hsu~~ , ~~Hao~~ Fan, ~~Pradeep~~ K ~~Singh~~ , ~~Rong~~ Wang , ~~George~~ Sukenick , ~~Carl~~ Nathan , ~~Gang~~ Lin, ~~Huilin~~ Li		Authors: Hsu, H.-C., Fan, H., Singh, P.K., Wang, R., Sukenick, G., Nathan, C., Lin, G., Li, H.

	Description: Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206		Description: Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Hao-Chi Hsu~~ , ~~Hao Fan~~, ~~Pradeep~~ K ~~Singh~~ , ~~Rong Wang~~ , ~~George Sukenick~~ , ~~Carl Nathan~~ , ~~Gang Lin~~, ~~Huilin Li~~]]		[[Category: Sukenick, G]]
			[[Category: Nathan, C]]
			[[Category: Singh, P.K]]
			[[Category: Lin, G]]
			[[Category: Li, H]]
			[[Category: Fan, H]]
			[[Category: Hsu, H.-C]]
			[[Category: Wang, R]]

OCA: Protected "5try" [edit=sysop:move=sysop]

2016-11-02T17:06:59Z

Protected "5try" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:06, 2 November 2016
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5try is ON HOLD Authors: Hao-Chi Hsu , Hao Fan, Pradeep K Singh , Rong Wang , George Sukenick , Carl Nathan , Gang Lin, Huilin Li Description: Stru...

2016-11-02T17:06:57Z

New page: '''Unreleased structure''' The entry 5try is ON HOLD Authors: Hao-Chi Hsu , Hao Fan, Pradeep K Singh , Rong Wang , George Sukenick , Carl Nathan , Gang Lin, Huilin Li Description: Stru...

New page

'''Unreleased structure'''

The entry 5try is ON HOLD

Authors: Hao-Chi Hsu , Hao Fan, Pradeep K Singh , Rong Wang , George Sukenick , Carl Nathan , Gang Lin, Huilin Li

Description: Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206
[[Category: Unreleased Structures]]
[[Category: Hao-Chi Hsu , Hao Fan, Pradeep K Singh , Rong Wang , George Sukenick , Carl Nathan , Gang Lin, Huilin Li]]