5uld - Revision history

OCA at 14:27, 6 March 2024

2024-03-06T14:27:58Z

← Older revision		Revision as of 14:27, 6 March 2024
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	<StructureSection load='5uld' size='340' side='right'caption='[[5uld]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='5uld' size='340' side='right'caption='[[5uld]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5uld]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibch Vibch~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ULD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5uld]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ULD FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.78Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5ul7\|5ul7]], [[5ul9\|5ul9]], [[5ule\|5ule]]~~<~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">VC_A0025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uld OCA], [https://pdbe.org/5uld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uld RCSB], [https://www.ebi.ac.uk/pdbsum/5uld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uld ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uld OCA], [~~http~~://pdbe.org/5uld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uld ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed~~ ==		[https://www.uniprot.org/uniprot/Q9KNE0_VIBCH Q9KNE0_VIBCH]
	Integral membrane proteins of the divalent anion/Na+ symporter (DASS) family translocate dicarboxylate, tricarboxylate or sulphate across cell membranes, typically by utilizing the preexisting Na+ gradient. The molecular determinants for substrate recognition by DASS remain obscure, largely owing to the absence of any substrate-bound DASS structure. Here we present 2.8-A resolution X-ray structures of VcINDY, a DASS from Vibrio cholerae that catalyses the co-transport of Na+ and succinate. These structures portray the Na+-bound VcINDY in complexes with succinate and citrate, elucidating the binding sites for substrate and two Na+ ions. Furthermore, we report the structures of a humanized variant of VcINDY in complexes with succinate and citrate, which predict how a human citrate-transporting DASS may interact with its bound substrate. Our findings provide insights into metabolite transport by DASS, establishing a molecular basis for future studies on the regulation of this transport process.

	~~Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant.,Nie R, Stark S, Symersky J, Kaplan RS, Lu M Nat Commun. 2017 Apr 24;8~~:~~15009. doi: 10.1038~~/~~ncomms15009. PMID:28436435<ref>PMID:28436435<~~/~~ref>~~

	~~From MEDLINE®/PubMed®, a database of the U.S~~. ~~National Library of Medicine~~.~~<br>~~
	</~~div>~~
	~~<div class="pdbe-citations 5uld" style="background-color:#fffaf0;"><~~/~~div>~~

	==See Also==		==See Also==
	*[[Symporter 3D structures\|Symporter 3D structures]]		*[[Symporter 3D structures\|Symporter 3D structures]]
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Vibch~~]]		[[Category: Vibrio cholerae O1 biovar El Tor str. N16961]]
	[[Category: Lu, M]]		[[Category: Lu M]]
	~~[[Category: Transport protein~~]]

OCA at 12:39, 23 September 2020

2020-09-23T12:39:04Z

← Older revision		Revision as of 12:39, 23 September 2020
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	==Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant==		==Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant==
	<StructureSection load='5uld' size='340' side='right' caption='[[5uld]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='5uld' size='340' side='right'caption='[[5uld]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5uld]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5ULD FirstGlance]. <br>		<table><tr><td colspan='2'>[[5uld]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibch Vibch]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ULD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ULD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ul7\|5ul7]], [[5ul9\|5ul9]], [[5ule\|5ule]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ul7\|5ul7]], [[5ul9\|5ul9]], [[5ule\|5ule]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uld OCA], [http://pdbe.org/5uld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uld RCSB], [http://www.ebi.ac.uk/pdbsum/5uld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uld ProSAT]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VC_A0025 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243277 VIBCH])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uld OCA], [http://pdbe.org/5uld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uld RCSB], [http://www.ebi.ac.uk/pdbsum/5uld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uld ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5uld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5uld" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
			[[Category: Vibch]]
	[[Category: Lu, M]]		[[Category: Lu, M]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 15:44, 17 May 2017

2017-05-17T15:44:03Z

@@ Line 1: / Line 1: @@
-The entry 5uld is ON HOLD
+==Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant==
-Authors:
+Structure and function of the divalent anion/Na+ symporter from Vibrio cholerae and a humanized variant.,Nie R, Stark S, Symersky J, Kaplan RS, Lu M Nat Commun. 2017 Apr 24;8:15009. doi: 10.1038/ncomms15009. PMID:28436435<ref>PMID:28436435</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 14:34, 9 March 2017

2017-03-09T14:34:46Z

← Older revision		Revision as of 14:34, 9 March 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5uld is ON HOLD ~~until sometime in the future~~		The entry 5uld is ON HOLD

	Authors: ~~Min Lu, Min Lu~~		Authors:

	Description: ~~protein 3~~		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Min Lu, Min Lu]]~~

OCA: Protected "5uld" [edit=sysop:move=sysop]

2017-02-01T16:46:55Z

Protected "5uld" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:46, 1 February 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5uld is ON HOLD until sometime in the future Authors: Min Lu, Min Lu Description: protein 3 Category: Unreleased Structures [[Category: Min Lu,...

2017-02-01T16:46:53Z

New page: '''Unreleased structure''' The entry 5uld is ON HOLD until sometime in the future Authors: Min Lu, Min Lu Description: protein 3 Category: Unreleased Structures [[Category: Min Lu,...

New page

'''Unreleased structure'''

The entry 5uld is ON HOLD until sometime in the future

Authors: Min Lu, Min Lu

Description: protein 3
[[Category: Unreleased Structures]]
[[Category: Min Lu, Min Lu]]