5usr - Revision history

OCA at 13:33, 4 October 2023

2023-10-04T13:33:43Z

← Older revision		Revision as of 13:33, 4 October 2023
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	<StructureSection load='5usr' size='340' side='right'caption='[[5usr]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='5usr' size='340' side='right'caption='[[5usr]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5usr]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5USR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5USR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5usr]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5USR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5USR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.09Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene~~></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFS1, NIFS, HUSSY-08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LYRM4, C6orf149, ISD11, CGI-203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), acpP, b1094, JW1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5usr OCA], [https://pdbe.org/5usr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5usr RCSB], [https://www.ebi.ac.uk/pdbsum/5usr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5usr ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5usr OCA], [~~http~~://pdbe.org/5usr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5usr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5usr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5usr ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http://www.uniprot.org/uniprot/NFS1_HUMAN NFS1_HUMAN]] Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency. [[http~~://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN] Severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NFS1_HUMAN NFS1_HUMAN]] Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.<ref>PMID:18650437</ref> [[http://www.uniprot.org/uniprot/ACP_ECOLI ACP_ECOLI]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217] [[http://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN]] Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.<ref>PMID:17331979</ref> <ref>PMID:19454487</ref>		[https://www.uniprot.org/uniprot/LYRM4_HUMAN LYRM4_HUMAN] Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.<ref>PMID:17331979</ref> <ref>PMID:19454487</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Cysteine desulfurase~~]]		[[Category: Escherichia coli K-12]]
	[[Category: ~~Ecoli]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barondeau~~, D P~~]]		[[Category: Barondeau DP]]
	[[Category: Cory~~, S A]]~~		[[Category: Cory SA]]
	~~[[Category: Acyl-carrier protein]]~~
	~~[[Category: Fe-s cluster assembly]]~~
	~~[[Category: Lyr]]~~
	~~[[Category: Nfs1]]~~
	~~[[Category: Transferase~~]]

OCA at 08:00, 27 November 2019

2019-11-27T08:00:13Z

← Older revision		Revision as of 08:00, 27 November 2019
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	==Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms==		==Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms==
	<StructureSection load='5usr' size='340' side='right' caption='[[5usr]], [[Resolution\|resolution]] 3.09Å' scene=''>		<StructureSection load='5usr' size='340' side='right'caption='[[5usr]], [[Resolution\|resolution]] 3.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5usr]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5USR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5USR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5usr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5USR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5USR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8Q1:S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]+dodecanethioate'>8Q1</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NFS1, NIFS, HUSSY-08 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LYRM4, C6orf149, ISD11, CGI-203 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), acpP, b1094, JW1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5usr OCA], [http://pdbe.org/5usr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5usr RCSB], [http://www.ebi.ac.uk/pdbsum/5usr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5usr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5usr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5usr OCA], [http://pdbe.org/5usr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5usr RCSB], [http://www.ebi.ac.uk/pdbsum/5usr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5usr ProSAT]</span></td></tr>
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	</div>		</div>
	<div class="pdbe-citations 5usr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5usr" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
			*[[Cysteine desulfurase 3D structures\|Cysteine desulfurase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Cysteine desulfurase]]		[[Category: Cysteine desulfurase]]
			[[Category: Ecoli]]
			[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Barondeau, D P]]		[[Category: Barondeau, D P]]
	[[Category: Cory, S A]]		[[Category: Cory, S A]]

OCA at 04:31, 21 September 2017

2017-09-21T04:31:52Z

@@ Line 1: / Line 1: @@
-The entry 5usr is ON HOLD  until Paper Publication
+==Crystal structure of human NFS1-ISD11 in complex with E. coli acyl-carrier protein at 3.09 angstroms==
-Authors:
+Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.,Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5325-E5334. doi:, 10.1073/pnas.1702849114. Epub 2017 Jun 20. PMID:28634302<ref>PMID:28634302</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 11:19, 5 April 2017

2017-04-05T11:19:33Z

← Older revision		Revision as of 11:19, 5 April 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5usr is ON HOLD		The entry 5usr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 19:21, 15 March 2017

2017-03-15T19:21:09Z

← Older revision		Revision as of 19:21, 15 March 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5usr is ON HOLD ~~until Paper Publication~~		The entry 5usr is ON HOLD

	Authors:		Authors:

OCA: Protected "5usr" [edit=sysop:move=sysop]

2017-03-09T14:52:50Z

Protected "5usr" [edit=sysop:move=sysop]

← Older revision	Revision as of 14:52, 9 March 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5usr is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-03-09T14:52:49Z

New page: '''Unreleased structure''' The entry 5usr is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5usr is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]