5vb4 - Revision history

OCA: Redirecting to 6dco

2018-05-30T05:21:09Z

Redirecting to 6dco

← Older revision		Revision as of 05:21, 30 May 2018
Line 1:		Line 1:
			#REDIRECT [[6dco]] This PDB entry is obsolete and replaced by 6dco
	~~==Bcl-xL complex with Beclin 1 BH3 domain T108D==~~
	~~<StructureSection load='5vb4' size='340' side='right' caption='~~[[~~5vb4~~]]~~, [[Resolution\|resolution]] 2.20Å' scene=''>~~
	~~== Structural highlights ==~~
	~~<table><tr><td colspan='2'>[[5vb4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information~~ is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB4 FirstGlance]. <br>
	~~</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>~~
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vax\|5vax]], [[5vau\|5vau]], [[5vb1\|5vb1]], [[5vay\|5vay]]</td></tr>~~
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb4 OCA], [http://pdbe.org/5vb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb4 ProSAT]</span></td></tr>
	~~</table>~~
	~~== Function ==~~
	[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by ~~a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>~~
	~~== References ==~~
	~~<references/>~~
	~~__TOC__~~
	~~</StructureSection>~~
	~~[[Category: Human]]~~
	~~[[Category: Fairlie, W D]]~~
	~~[[Category: Lee, E F]]~~
	~~[[Category: Smith, B J]]~~
	~~[[Category: Yao, S]]~~
	~~[[Category: Apoptosis]]~~
	~~[[Category: Autophagy]]~~
	~~[[Category: Bcl-2]]~~
	~~[[Category: Beclin 1]]~~

OCA at 06:37, 18 April 2018

2018-04-18T06:37:16Z

← Older revision		Revision as of 06:37, 18 April 2018
Line 3:		Line 3:
	<StructureSection load='5vb4' size='340' side='right' caption='[[5vb4]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5vb4' size='340' side='right' caption='[[5vb4]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vb4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vb4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vax\|5vax]], [[5vau\|5vau]], [[5vb1\|5vb1]], [[5vay\|5vay]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vax\|5vax]], [[5vau\|5vau]], [[5vb1\|5vb1]], [[5vay\|5vay]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb4 OCA], [http://pdbe.org/5vb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb4 OCA], [http://pdbe.org/5vb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb4 ProSAT]</span></td></tr>
	</table>		</table>
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Fairlie, W D]]		[[Category: Fairlie, W D]]
	[[Category: Lee, E F]]		[[Category: Lee, E F]]

OCA at 05:53, 4 April 2018

2018-04-04T05:53:14Z

← Older revision		Revision as of 05:53, 4 April 2018
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 5vb4 is ~~ON HOLD until Paper Publication~~		==Bcl-xL complex with Beclin 1 BH3 domain T108D==
			<StructureSection load='5vb4' size='340' side='right' caption='[[5vb4]], [[Resolution\|resolution]] 2.20Å' scene=''>
	~~Authors~~: ~~Lee~~, E.F., ~~Smith, B~~.J., ~~Yao~~, S., ~~Fairlie~~, W.D.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5vb4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VB4 FirstGlance]. <br>
	~~Description~~: Bcl-~~xL complex with Beclin 1 BH3 domain T108D~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vax\|5vax]], [[5vau\|5vau]], [[5vb1\|5vb1]], [[5vay\|5vay]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vb4 OCA], [http://pdbe.org/5vb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vb4 RCSB], [http://www.ebi.ac.uk/pdbsum/5vb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vb4 ProSAT]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/BECN1_HUMAN BECN1_HUMAN]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.<ref>PMID:20208530</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Fairlie, W D]]
			[[Category: Lee, E F]]
			[[Category: Smith, B J]]
	[[Category: Yao, S]]		[[Category: Yao, S]]
	[[Category: ~~Lee, E.F~~]]		[[Category: Apoptosis]]
	[[Category: ~~Fairlie, W.D~~]]		[[Category: Autophagy]]
	[[Category: ~~Smith, B.J~~]]		[[Category: Bcl-2]]
			[[Category: Beclin 1]]

OCA at 05:54, 21 March 2018

2018-03-21T05:54:55Z

← Older revision		Revision as of 05:54, 21 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5vb4 is ON HOLD		The entry 5vb4 is ON HOLD until Paper Publication

	Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.		Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.

OCA at 04:55, 14 March 2018

2018-03-14T04:55:54Z

← Older revision		Revision as of 04:55, 14 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5vb4 is ON HOLD ~~until Paper Publication~~		The entry 5vb4 is ON HOLD

	Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.		Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.
Line 7:		Line 7:
	Description: Bcl-xL complex with Beclin 1 BH3 domain T108D		Description: Bcl-xL complex with Beclin 1 BH3 domain T108D
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Fairlie, W.D]]~~
	[[Category: Yao, S]]		[[Category: Yao, S]]
	[[Category: Lee, E.F]]		[[Category: Lee, E.F]]
			[[Category: Fairlie, W.D]]
	[[Category: Smith, B.J]]		[[Category: Smith, B.J]]

OCA at 13:58, 27 September 2017

2017-09-27T13:58:27Z

← Older revision		Revision as of 13:58, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5vb4 is ON HOLD until ~~sometime in the future~~		The entry 5vb4 is ON HOLD until Paper Publication

	Authors: ~~Erinna~~ F.~~Lee~~, ~~Brian~~ J.~~Smith~~, ~~Shenggen~~ Yao, ~~Walter~~ D.~~Fairlie~~		Authors: Lee, E.F., Smith, B.J., Yao, S., Fairlie, W.D.

	Description: Bcl-xL complex with Beclin 1 BH3 domain T108D		Description: Bcl-xL complex with Beclin 1 BH3 domain T108D
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Erinna F~~.Lee, ~~Brian J~~.Smith, ~~Shenggen Yao, Walter D~~.~~Fairlie~~]]		[[Category: Fairlie, W.D]]
			[[Category: Yao, S]]
			[[Category: Lee, E.F]]
			[[Category: Smith, B.J]]

OCA at 11:15, 19 April 2017

2017-04-19T11:15:04Z

← Older revision		Revision as of 11:15, 19 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5vb4 is ON HOLD		The entry 5vb4 is ON HOLD until sometime in the future

	Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie		Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie

OCA: Protected "5vb4" [edit=sysop:move=sysop]

2017-04-05T11:52:56Z

Protected "5vb4" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:52, 5 April 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5vb4 is ON HOLD Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie Description: Bcl-xL complex with Beclin 1 BH3 domain T108D [[C...

2017-04-05T11:52:55Z

New page: '''Unreleased structure''' The entry 5vb4 is ON HOLD Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie Description: Bcl-xL complex with Beclin 1 BH3 domain T108D [[C...

New page

'''Unreleased structure'''

The entry 5vb4 is ON HOLD

Authors: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie

Description: Bcl-xL complex with Beclin 1 BH3 domain T108D
[[Category: Unreleased Structures]]
[[Category: Erinna F.Lee, Brian J.Smith, Shenggen Yao, Walter D.Fairlie]]