5vmf - Revision history

OCA at 13:51, 4 October 2023

2023-10-04T13:51:27Z

← Older revision		Revision as of 13:51, 4 October 2023
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	<StructureSection load='5vmf' size='340' side='right'caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5vmf' size='340' side='right'caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~I18a0 I18a0~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Brevig_Mission/1/1918(H1N1)) Influenza A virus (A/Brevig Mission/1/1918(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VMF FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~SIA~~:O-~~SIALIC+ACID~~'>~~SIA~~</scene><~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900046:6-sialyl-N-acetyllactosamine'>PRD_900046</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[5vmc\|5vmc]], [[5vmg\|5vmg]], [[5vmj\|5vmj]]~~</~~div~~><~~/td></tr>~~
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~HA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=88776 I18A0])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [https://pdbe.org/5vmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [https://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [https://pdbe.org/5vmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [https://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HEMA_I18A0 HEMA_I18A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).		[https://www.uniprot.org/uniprot/HEMA_I18A0 HEMA_I18A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: I18a0]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kondrashkina, E]]		[[Category: Kondrashkina E]]
	[[Category: Ni, F]]		[[Category: Ni F]]
	[[Category: Wang, Q]]		[[Category: Wang Q]]
	~~[[Category: Hemagglutinin]]~~
	~~[[Category: Influenza]]~~
	~~[[Category: Receptor]]~~
	~~[[Category: Viral protein~~]]

OCA at 11:30, 23 March 2022

2022-03-23T11:30:48Z

OCA at 08:40, 30 September 2020

2020-09-30T08:40:13Z

← Older revision		Revision as of 08:40, 30 September 2020
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	==Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN==		==Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN==
	<StructureSection load='5vmf' size='340' side='right' caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5vmf' size='340' side='right'caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5VMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I18a0 I18a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VMF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~GAL~~:~~BETA~~-D-~~GALACTOSE~~'>~~GAL~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vmc\|5vmc]], [[5vmg\|5vmg]], [[5vmj\|5vmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vmc\|5vmc]], [[5vmg\|5vmg]], [[5vmj\|5vmj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [http://pdbe.org/5vmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [http://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=88776 I18A0])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [http://pdbe.org/5vmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [http://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5vmf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vmf" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: I18a0]]
			[[Category: Large Structures]]
	[[Category: Kondrashkina, E]]		[[Category: Kondrashkina, E]]
	[[Category: Ni, F]]		[[Category: Ni, F]]

OCA at 07:32, 8 November 2017

2017-11-08T07:32:15Z

@@ Line 1: / Line 1: @@
-The entry 5vmf is ON HOLD  until Paper Publication
+==Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN==
-Authors: Ni, F., Kondrashkina, E., Wang, Q.
+Determinant of receptor-preference switch in influenza hemagglutinin.,Ni F, Kondrashkina E, Wang Q Virology. 2017 Oct 18;513:98-107. doi: 10.1016/j.virol.2017.10.010. PMID:29055255<ref>PMID:29055255</ref>
-Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Ni, F]]
 [[Category: Wang, Q]]

OCA at 13:59, 17 May 2017

2017-05-17T13:59:26Z

← Older revision		Revision as of 13:59, 17 May 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5vmf is ON HOLD		The entry 5vmf is ON HOLD until Paper Publication

	Authors: Ni, F., Kondrashkina, E., Wang, Q.		Authors: Ni, F., Kondrashkina, E., Wang, Q.

OCA at 11:11, 10 May 2017

2017-05-10T11:11:11Z

← Older revision		Revision as of 11:11, 10 May 2017
Line 3:		Line 3:
	The entry 5vmf is ON HOLD		The entry 5vmf is ON HOLD

	Authors: ~~Fengyun~~ Ni, ~~Elena~~ Kondrashkina, ~~Qinghua~~ Wang		Authors: Ni, F., Kondrashkina, E., Wang, Q.

	Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN		Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Fengyun~~ Ni, ~~Elena~~ Kondrashkina, ~~Qinghua~~ Wang]]		[[Category: Ni, F]]
			[[Category: Kondrashkina, E]]
			[[Category: Wang, Q]]

OCA: Protected "5vmf" [edit=sysop:move=sysop]

2017-05-04T11:28:56Z

Protected "5vmf" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:28, 4 May 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5vmf is ON HOLD Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN [[C...

2017-05-04T11:28:55Z

New page: '''Unreleased structure''' The entry 5vmf is ON HOLD Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN [[C...

New page

'''Unreleased structure'''

The entry 5vmf is ON HOLD

Authors: Fengyun Ni, Elena Kondrashkina, Qinghua Wang

Description: Influenza hemagglutinin H1 mutant DH1D in complex with 6'SLN
[[Category: Unreleased Structures]]
[[Category: Fengyun Ni, Elena Kondrashkina, Qinghua Wang]]

← Older revision		Revision as of 11:30, 23 March 2022
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	<StructureSection load='5vmf' size='340' side='right'caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5vmf' size='340' side='right'caption='[[5vmf]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/I18a0 I18a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5VMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vmf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/I18a0 I18a0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VMF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vmc\|5vmc]], [[5vmg\|5vmg]], [[5vmj\|5vmj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5vmc\|5vmc]], [[5vmg\|5vmg]], [[5vmj\|5vmj]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=88776 I18A0])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=88776 I18A0])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [~~http~~://pdbe.org/5vmf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmf OCA], [https://pdbe.org/5vmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vmf RCSB], [https://www.ebi.ac.uk/pdbsum/5vmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HEMA_I18A0 HEMA_I18A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).		[[https://www.uniprot.org/uniprot/HEMA_I18A0 HEMA_I18A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==