5xes - Revision history

OCA at 10:30, 14 June 2023

2023-06-14T10:30:45Z

← Older revision		Revision as of 10:30, 14 June 2023
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	==TK9 NMR structure in SDS micelle==		==TK9 NMR structure in SDS micelle==
	<StructureSection load='5xes' size='340' side='right'caption='[[5xes~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='5xes' size='340' side='right'caption='[[5xes]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xes]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XES OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xes]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XES FirstGlance]. <br>
	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xer\|5xer]]</td></tr>~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xes OCA], [https://pdbe.org/5xes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xes RCSB], [https://www.ebi.ac.uk/pdbsum/5xes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xes ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xes OCA], [~~http~~://pdbe.org/5xes PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xes RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xes PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xes ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/VEMP_SARS VEMP_SARS] Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis (By similarity). Activates the host NLRP3 inflammasome, leading to IL-1beta overproduction.[HAMAP-Rule:MF_04204]<ref>PMID:24788150</ref> <ref>PMID:26331680</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Bhunia, A~~]]		[[Category: Severe acute respiratory syndrome-related coronavirus]]
	[[Category: ~~Ghosh,~~ A]]		[[Category: Bhunia A]]
	[[Category: ~~Protein fibril~~]]		[[Category: Ghosh A]]

OCA at 09:26, 30 October 2019

2019-10-30T09:26:21Z

← Older revision		Revision as of 09:26, 30 October 2019
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	==TK9 NMR structure in SDS micelle==		==TK9 NMR structure in SDS micelle==
	<StructureSection load='5xes' size='340' side='right' caption='[[5xes]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5xes' size='340' side='right'caption='[[5xes]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xes]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XES FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xes]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XES FirstGlance]. <br>
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xes OCA], [http://pdbe.org/5xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xes RCSB], [http://www.ebi.ac.uk/pdbsum/5xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xes ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xes OCA], [http://pdbe.org/5xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xes RCSB], [http://www.ebi.ac.uk/pdbsum/5xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xes ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In recent years, several studies based on the interaction of self-assembling short peptides derived from viroporins with model membranes, have improved our understanding of the molecular mechanism of corona virus (CoV) infection under physiological conditions. In this study, we have characterized the mechanism of membrane interaction of a short, 9-residue peptide TK9 (T(55)VYVYSRVK(63)) that had been derived from the carboxyl terminal of the Severe Acute Respiratory Syndrome (SARS) corona virus (SARS CoV) envelope (E) protein. The peptide has been studied for its physical changes in the presence of both zwitterionic DPC and negatively charged SDS model membrane micelles, respectively, with the help of a battery of biophysical techniques including two-dimensional solution state NMR spectroscopy. Interestingly, in both micellar environments, TK9 adopted an alpha helical conformation; however, the helical propensities were much higher in the case of DPC compared to those of SDS micelle, suggesting that TK9 has more specificity towards eukaryotic cell membrane than the bacterial cell membrane. The orientation of the peptide TK9 also varies in the different micellar environments. The peptide's affinity was further manifested by its pronounced membrane disruption ability towards the mammalian compared to the bacterial membrane mimic. Collectively, the in-depth structural information on the interaction of TK9 with different membrane environments explains the host specificity and membrane orientation owing to subsequent membrane disruption implicated in the viral pathogenesis.

			Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study.,Ghosh A, Bhattacharyya D, Bhunia A Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):335-346. doi:, 10.1016/j.bbamem.2017.10.015. Epub 2017 Oct 14. PMID:29038024<ref>PMID:29038024</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 5xes" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Bhunia, A]]		[[Category: Bhunia, A]]
	[[Category: Ghosh, A]]		[[Category: Ghosh, A]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA at 05:39, 18 April 2018

2018-04-18T05:39:39Z

← Older revision		Revision as of 05:39, 18 April 2018
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	~~'''Unreleased structure'''~~

	~~The entry~~ 5xes is ~~ON HOLD until Paper Publication~~		==TK9 NMR structure in SDS micelle==
			<StructureSection load='5xes' size='340' side='right' caption='[[5xes]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~Authors~~: ~~Ghosh~~, A., ~~Bhunia~~, A.		== Structural highlights ==
			<table><tr><td colspan='2'>[[5xes]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XES FirstGlance]. <br>
	~~Description~~: ~~TK9 NMR structure in SDS micelle~~		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xer\|5xer]]</td></tr>
	[~~[Category~~: ~~Unreleased Structures]~~]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xes OCA], [http://pdbe.org/5xes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xes RCSB], [http://www.ebi.ac.uk/pdbsum/5xes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xes ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
	[[Category: Bhunia, A]]		[[Category: Bhunia, A]]
	[[Category: Ghosh, A]]		[[Category: Ghosh, A]]
			[[Category: Protein fibril]]

OCA at 15:25, 27 September 2017

2017-09-27T15:25:49Z

← Older revision		Revision as of 15:25, 27 September 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 5xes is ON HOLD		The entry 5xes is ON HOLD until Paper Publication

	Authors: Ghosh, A., Bhunia, A.		Authors: Ghosh, A., Bhunia, A.
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	Description: TK9 NMR structure in SDS micelle		Description: TK9 NMR structure in SDS micelle
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Bhunia, A]]
	[[Category: Ghosh, A]]		[[Category: Ghosh, A]]
	~~[[Category: Bhunia, A]]~~

OCA at 12:06, 19 April 2017

2017-04-19T12:06:20Z

← Older revision		Revision as of 12:06, 19 April 2017
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	The entry 5xes is ON HOLD		The entry 5xes is ON HOLD

	Authors: ~~Anirban~~ Ghosh, ~~Anirban~~ Bhunia		Authors: Ghosh, A., Bhunia, A.

	Description: TK9 NMR structure in SDS micelle		Description: TK9 NMR structure in SDS micelle
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: ~~Anirban~~ Ghosh, ~~Anirban~~ Bhunia]]		[[Category: Ghosh, A]]
			[[Category: Bhunia, A]]

OCA: Protected "5xes" [edit=sysop:move=sysop]

2017-04-12T10:42:20Z

Protected "5xes" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:42, 12 April 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5xes is ON HOLD Authors: Anirban Ghosh, Anirban Bhunia Description: TK9 NMR structure in SDS micelle Category: Unreleased Structures [[Category...

2017-04-12T10:42:19Z

New page: '''Unreleased structure''' The entry 5xes is ON HOLD Authors: Anirban Ghosh, Anirban Bhunia Description: TK9 NMR structure in SDS micelle Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 5xes is ON HOLD

Authors: Anirban Ghosh, Anirban Bhunia

Description: TK9 NMR structure in SDS micelle
[[Category: Unreleased Structures]]
[[Category: Anirban Ghosh, Anirban Bhunia]]