5yle - Revision history

OCA at 10:08, 15 November 2023

2023-11-15T10:08:13Z

← Older revision		Revision as of 10:08, 15 November 2023
Line 1:		Line 1:

	==MCR-1 complex with ethanolamine (ETA)==		==MCR-1 complex with ethanolamine (ETA)==
	<StructureSection load='5yle' size='340' side='right' caption='[[5yle]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5yle' size='340' side='right'caption='[[5yle]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5yle]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5yle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YLE FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ETA:ETHANOLAMINE'>ETA</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~TPO~~:~~PHOSPHOTHREONINE~~'>~~TPO~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[5ylc\|5ylc]]~~, ~~[[5ylf\|5ylf]]~~<~~/td></tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yle OCA], [https://pdbe.org/5yle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yle RCSB], [https://www.ebi.ac.uk/pdbsum/5yle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yle ProSAT]</span></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">mcr1, mcr-1, APZ14_31440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yle OCA], [~~http~~://pdbe.org/5yle PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yle RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yle PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yle ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX]] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>		[https://www.uniprot.org/uniprot/MCR1_ECOLX MCR1_ECOLX] Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).<ref>PMID:26603172</ref> Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E.coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5 mg/ml to 2.0 mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172).<ref>PMID:26603172</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Chen, P]]		[[Category: Large Structures]]
	[[Category: Lei, J]]		[[Category: Chen P]]
	[[Category: Liu, Y]]		[[Category: Lei J]]
	[[Category: Shi~~, M Y~~]]		[[Category: Liu Y]]
	[[Category: Song~~, G J~~]]		[[Category: Shi MY]]
	[[Category: Wei~~, P C~~]]		[[Category: Song GJ]]
	[[Category: Yin, L]]		[[Category: Wei PC]]
	[[Category: Zhou~~, Y F]]~~		[[Category: Yin L]]
	~~[[Category: Phosphoethanolamine transferase]]~~		[[Category: Zhou YF]]
	~~[[Category: Plasmid-mediated transferable colistin resistance gene]]~~
	~~[[Category: Transferase~~]]

OCA at 08:25, 22 February 2018

2018-02-22T08:25:12Z

← Older revision		Revision as of 08:25, 22 February 2018
Line 3:		Line 3:
	<StructureSection load='5yle' size='340' side='right' caption='[[5yle]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='5yle' size='340' side='right' caption='[[5yle]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5yle]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YLE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5yle]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YLE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ylc\|5ylc]], [[5ylf\|5ylf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ylc\|5ylc]], [[5ylf\|5ylf]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mcr1, mcr-1, APZ14_31440 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yle OCA], [http://pdbe.org/5yle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yle RCSB], [http://www.ebi.ac.uk/pdbsum/5yle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yle ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yle OCA], [http://pdbe.org/5yle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yle RCSB], [http://www.ebi.ac.uk/pdbsum/5yle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yle ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Chen, P]]		[[Category: Chen, P]]
	[[Category: Lei, J]]		[[Category: Lei, J]]

OCA at 07:42, 8 November 2017

2017-11-08T07:42:06Z

@@ Line 1: / Line 1: @@
-The entry 5yle is ON HOLD
+==MCR-1 complex with ethanolamine (ETA)==
-Authors:
+Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.,Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P, Yin L FASEB J. 2017 Oct 27. pii: fj.201700705R. doi: 10.1096/fj.201700705R. PMID:29079699<ref>PMID:29079699</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "5yle" [edit=sysop:move=sysop]

2017-10-25T05:40:48Z

Protected "5yle" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:40, 25 October 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5yle is ON HOLD Authors: Description: Category: Unreleased Structures

2017-10-25T05:40:47Z

New page: '''Unreleased structure''' The entry 5yle is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5yle is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]