5zhy - Revision history

OCA at 08:56, 22 November 2023

2023-11-22T08:56:12Z

← Older revision		Revision as of 08:56, 22 November 2023
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	<StructureSection load='5zhy' size='340' side='right'caption='[[5zhy]], [[Resolution\|resolution]] 2.44Å' scene=''>		<StructureSection load='5zhy' size='340' side='right'caption='[[5zhy]], [[Resolution\|resolution]] 2.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_229E Human coronavirus 229E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [~~http~~://pdbe.org/5zhy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.441Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [https://pdbe.org/5zhy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [https://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22]] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).		[https://www.uniprot.org/uniprot/SPIKE_CVH22 SPIKE_CVH22] S1 region attaches the virion to the cell membrane by interacting with human ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human coronavirus 229E]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen X]]
	[[Category: Rao, Z]]		[[Category: Rao Z]]
	[[Category: Yan, M]]		[[Category: Yan M]]
	[[Category: Yang, H]]		[[Category: Yang H]]
	[[Category: Zhang, W]]		[[Category: Zhang W]]
	[[Category: Zheng, Q]]		[[Category: Zheng Q]]
	[[Category: Zhou, W]]		[[Category: Zhou W]]
	~~[[Category: Broad-spectrum inhibitor design]]~~
	~~[[Category: Membrane fusion]]~~
	~~[[Category: Viral protein~~]]

OCA at 21:19, 28 October 2020

2020-10-28T21:19:51Z

← Older revision		Revision as of 21:19, 28 October 2020
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	==Structural characterization of the HCoV-229E fusion core==		==Structural characterization of the HCoV-229E fusion core==
	<StructureSection load='5zhy' size='340' side='right' caption='[[5zhy]], [[Resolution\|resolution]] 2.44Å' scene=''>		<StructureSection load='5zhy' size='340' side='right'caption='[[5zhy]], [[Resolution\|resolution]] 2.44Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zhy]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZHY FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca.weizmann~~.~~ac.il/oca-docs~~/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [http://pdbe.org/5zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [http://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhy OCA], [http://pdbe.org/5zhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhy RCSB], [http://www.ebi.ac.uk/pdbsum/5zhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5zhy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zhy" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Sandbox 3001\|Sandbox 3001]]
			*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Rao, Z]]		[[Category: Rao, Z]]

OCA at 05:54, 6 June 2018

2018-06-06T05:54:03Z

@@ Line 1: / Line 1: @@
-The entry 5zhy is ON HOLD
+==Structural characterization of the HCoV-229E fusion core==
-Authors:
+Structural characterization of the HCoV-229E fusion core.,Zhang W, Zheng Q, Yan M, Chen X, Yang H, Zhou W, Rao Z Biochem Biophys Res Commun. 2018 Mar 4;497(2):705-712. doi:, 10.1016/j.bbrc.2018.02.136. Epub 2018 Feb 16. PMID:29458023<ref>PMID:29458023</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "5zhy" [edit=sysop:move=sysop]

2018-03-21T06:01:49Z

Protected "5zhy" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:01, 21 March 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 5zhy is ON HOLD Authors: Description: Category: Unreleased Structures

2018-03-21T06:01:47Z

New page: '''Unreleased structure''' The entry 5zhy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zhy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]