6aps - Revision history

OCA at 14:22, 4 October 2023

2023-10-04T14:22:41Z

← Older revision		Revision as of 14:22, 4 October 2023
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	<StructureSection load='6aps' size='340' side='right'caption='[[6aps]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='6aps' size='340' side='right'caption='[[6aps]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6aps]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SV2:[{2-[(GUANINE-9-YL)METHYL]PROPANE-1,3-DIYL}BIS(OXYMETHYLENE)]BIS(PHOSPHONIC+ACID)'>SV2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.762Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SV2:[{2-[(GUANINE-9-YL)METHYL]PROPANE-1,3-DIYL}BIS(OXYMETHYLENE)]BIS(PHOSPHONIC+ACID)'>SV2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aps OCA], [~~http~~://pdbe.org/6aps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6aps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6aps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aps OCA], [https://pdbe.org/6aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aps RCSB], [https://www.ebi.ac.uk/pdbsum/6aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).		[https://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Hypoxanthine phosphoribosyltransferase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Guddat, L W~~]]		[[Category: Trypanosoma brucei brucei]]
	[[Category: ~~Teran, D~~]]		[[Category: Guddat LW]]
	[[Category: ~~Acyclic nucleoside biphosphonate]]~~		[[Category: Teran D]]
	~~[[Category: Purine salvage]]~~
	~~[[Category: Transferase]]~~
	~~[[Category: Trypanosoma brucei~~]]

OCA at 21:30, 28 October 2020

2020-10-28T21:30:27Z

← Older revision		Revision as of 21:30, 28 October 2020
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	==Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid==		==Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid==
	<StructureSection load='6aps' size='340' side='right' caption='[[6aps]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='6aps' size='340' side='right'caption='[[6aps]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6aps]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[6aps]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6APS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SV2:[{2-[(GUANINE-9-YL)METHYL]PROPANE-1,3-DIYL}BIS(OXYMETHYLENE)]BIS(PHOSPHONIC+ACID)'>SV2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SV2:[{2-[(GUANINE-9-YL)METHYL]PROPANE-1,3-DIYL}BIS(OXYMETHYLENE)]BIS(PHOSPHONIC+ACID)'>SV2</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aps OCA], [http://pdbe.org/6aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aps RCSB], [http://www.ebi.ac.uk/pdbsum/6aps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aps OCA], [http://pdbe.org/6aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aps RCSB], [http://www.ebi.ac.uk/pdbsum/6aps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 6aps" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6aps" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
			[[Category: Large Structures]]
	[[Category: Guddat, L W]]		[[Category: Guddat, L W]]
	[[Category: Teran, D]]		[[Category: Teran, D]]

OCA at 06:28, 14 March 2018

2018-03-14T06:28:31Z

@@ Line 1: / Line 1: @@
-The entry 6aps is ON HOLD  until Paper Publication
+==Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid==
-Authors: Teran, D., Guddat, L.W.
+Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.,Dolezelova E, Teran D, Gahura O, Kotrbova Z, Prochazkova M, Keough D, Spacek P, Hockova D, Guddat L, Zikova A PLoS Negl Trop Dis. 2018 Feb 26;12(2):e0006301. doi:, 10.1371/journal.pntd.0006301. eCollection 2018 Feb. PMID:29481567<ref>PMID:29481567</ref>
-Description: Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Guddat, L.W]]
+<div class="pdbe-citations 6aps" style="background-color:#fffaf0;"></div>
 [[Category: Teran, D]]

OCA: Protected "6aps" [edit=sysop:move=sysop]

2017-09-27T16:39:28Z

Protected "6aps" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:39, 27 September 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6aps is ON HOLD until Paper Publication Authors: Teran, D., Guddat, L.W. Description: Trypanosoma brucei hypoxanthine guanine phosphoribosyltransfe...

2017-09-27T16:39:26Z

New page: '''Unreleased structure''' The entry 6aps is ON HOLD until Paper Publication Authors: Teran, D., Guddat, L.W. Description: Trypanosoma brucei hypoxanthine guanine phosphoribosyltransfe...

New page

'''Unreleased structure'''

The entry 6aps is ON HOLD until Paper Publication

Authors: Teran, D., Guddat, L.W.

Description: Trypanosoma brucei hypoxanthine guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3 diyl)bis(oxy)]bis(methylene))diphosphonic acid
[[Category: Unreleased Structures]]
[[Category: Guddat, L.W]]
[[Category: Teran, D]]