6awk - Revision history

OCA at 07:29, 1 May 2024

2024-05-01T07:29:35Z

← Older revision		Revision as of 07:29, 1 May 2024
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	==PawL-Derived Peptide PLP-12==		==PawL-Derived Peptide PLP-12==
	<StructureSection load='6awk' size='340' side='right'caption='[[6awk~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='6awk' size='340' side='right'caption='[[6awk]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6awk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[6awk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Senecio_vulgaris Senecio vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AWK FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awk OCA], [~~http~~://pdbe.org/6awk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6awk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6awk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6awk ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awk OCA], [https://pdbe.org/6awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6awk RCSB], [https://www.ebi.ac.uk/pdbsum/6awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6awk ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Orbitides are cyclic ribosomally-synthesized and post-translationally modified peptides (RiPPs) from plants; they consist of standard amino acids arranged in an unbroken chain of peptide bonds. These cyclic peptides are stable and range in size and topologies making them potential scaffolds for peptide drugs; some display valuable biological activities. Recently two orbitides whose sequences were buried in those of seed storage albumin precursors were said to represent the first observable step in the evolution of larger and hydrophilic bicyclic peptides. Here, guided by transcriptome data, we investigated peptide extracts of 40 species specifically for the more hydrophobic orbitides and confirmed 44 peptides by tandem mass spectrometry, as well as obtaining solution structures for four of them by NMR. Acquiring transcriptomes from the phylogenetically important Corymboideae family confirmed the precursor genes for the peptides (called PawS1-Like or PawL1) are confined to the Asteroideae, a subfamily of the huge plant family Asteraceae. To be confined to the Asteroideae indicates these peptides arose during the Eocene epoch around 45 Mya. Unlike other orbitides, all PawL-derived Peptides contain an Asp residue, needed for processing by asparaginyl endopeptidase. This study has revealed what is likely to be a very large new family of orbitides, uniquely buried alongside albumin and processed by asparaginyl endopeptidase.

	A family of small, cyclic peptides buried in preproalbumin since the Eocene epoch.,Fisher MF, Zhang J, Taylor NL, Howard MJ, Berkowitz O, Debowski AW, Behsaz B, Whelan J, Pevzner PA, Mylne JS Plant Direct. 2018 Feb;2(2). doi: 10.1002/pld3.42. Epub 2018 Feb 28. PMID:30417166<ref>PMID:30417166</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 6awk" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Fisher, M~~]]		[[Category: Senecio vulgaris]]
	[[Category: ~~Howard,~~ M J]]		[[Category: Fisher M]]
	[[Category: ~~Mylne, J S~~]]		[[Category: Howard MJ]]
	[[Category: ~~Buried peptide]]~~		[[Category: Mylne JS]]
	~~[[Category: Cyclic peptide]]~~
	~~[[Category: De novo protein]]~~
	~~[[Category: Orbitide]]~~
	~~[[Category: Plant peptide~~]]

OCA at 10:08, 1 January 2020

2020-01-01T10:08:28Z

← Older revision		Revision as of 10:08, 1 January 2020
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	==PawL-Derived Peptide PLP-12==		==PawL-Derived Peptide PLP-12==
	<StructureSection load='6awk' size='340' side='right' caption='[[6awk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6awk' size='340' side='right'caption='[[6awk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6awk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AWK FirstGlance]. <br>		<table><tr><td colspan='2'>[[6awk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AWK FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Fisher, M]]		[[Category: Fisher, M]]
	[[Category: Howard, M J]]		[[Category: Howard, M J]]

OCA at 20:53, 2 December 2018

2018-12-02T20:53:19Z

@@ Line 6: / Line 6: @@
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awk OCA], [http://pdbe.org/6awk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6awk RCSB], [http://www.ebi.ac.uk/pdbsum/6awk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6awk ProSAT]</span></td></tr>
 </table>
 __TOC__
 </StructureSection>

OCA at 05:06, 8 March 2018

2018-03-08T05:06:26Z

← Older revision		Revision as of 05:06, 8 March 2018
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	~~'''Unreleased structure'''~~

	~~The entry 6awk is ON HOLD until Paper Publication~~		==PawL-Derived Peptide PLP-12==
			<StructureSection load='6awk' size='340' side='right' caption='[[6awk]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~Authors: Fisher, M., Mylne, J.S., Howard, M.J.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[6awk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AWK FirstGlance]. <br>
	~~Description:~~ PawL-Derived Peptide PLP-12		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awk OCA], [http://pdbe.org/6awk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6awk RCSB], [http://www.ebi.ac.uk/pdbsum/6awk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6awk ProSAT]</span></td></tr>
	[[~~Category: Unreleased Structures~~]]		</table>
	[[~~Category~~: ~~Mylne, J~~.S]]		__TOC__
	[[~~Category~~: ~~Howard~~, M.J]]		</StructureSection>
	[[Category: Fisher, M]]		[[Category: Fisher, M]]
			[[Category: Howard, M J]]
			[[Category: Mylne, J S]]
			[[Category: Buried peptide]]
			[[Category: Cyclic peptide]]
			[[Category: De novo protein]]
			[[Category: Orbitide]]
			[[Category: Plant peptide]]

OCA at 05:26, 11 October 2017

2017-10-11T05:26:59Z

← Older revision		Revision as of 05:26, 11 October 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6awk is ON HOLD		The entry 6awk is ON HOLD until Paper Publication

	Authors: Fisher, M., Mylne, J.S., Howard, M.J.		Authors: Fisher, M., Mylne, J.S., Howard, M.J.
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	Description: PawL-Derived Peptide PLP-12		Description: PawL-Derived Peptide PLP-12
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Fisher, M]]~~
	[[Category: Mylne, J.S]]		[[Category: Mylne, J.S]]
	[[Category: Howard, M.J]]		[[Category: Howard, M.J]]
			[[Category: Fisher, M]]

OCA: Protected "6awk" [edit=sysop:move=sysop]

2017-09-27T16:52:45Z

Protected "6awk" [edit=sysop:move=sysop]

← Older revision	Revision as of 16:52, 27 September 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6awk is ON HOLD Authors: Fisher, M., Mylne, J.S., Howard, M.J. Description: PawL-Derived Peptide PLP-12 Category: Unreleased Structures [[Categ...

2017-09-27T16:52:44Z

New page: '''Unreleased structure''' The entry 6awk is ON HOLD Authors: Fisher, M., Mylne, J.S., Howard, M.J. Description: PawL-Derived Peptide PLP-12 Category: Unreleased Structures [[Categ...

New page

'''Unreleased structure'''

The entry 6awk is ON HOLD

Authors: Fisher, M., Mylne, J.S., Howard, M.J.

Description: PawL-Derived Peptide PLP-12
[[Category: Unreleased Structures]]
[[Category: Fisher, M]]
[[Category: Mylne, J.S]]
[[Category: Howard, M.J]]