6bf2 - Revision history

OCA at 10:38, 14 June 2023

2023-06-14T10:38:15Z

← Older revision		Revision as of 10:38, 14 June 2023
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	==Solution structure of a Bcl-xL S62E mutant==		==Solution structure of a Bcl-xL S62E mutant==
	<StructureSection load='6bf2' size='340' side='right'caption='[[6bf2~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='6bf2' size='340' side='right'caption='[[6bf2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [https://pdbe.org/6bf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [~~http~~://pdbe.org/6bf2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>		[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Follis, A Viacava]]~~		[[Category: Kriwacki RW]]
	[[Category: Kriwacki~~, R W~~]]		[[Category: Phillips A]]
	[[Category: Phillips, A]]		[[Category: Viacava Follis A]]
	[[Category: ~~Apoptosis~~]]

OCA at 09:52, 4 December 2019

2019-12-04T09:52:14Z

← Older revision		Revision as of 09:52, 4 December 2019
Line 1:		Line 1:

	==Solution structure of a Bcl-xL S62E mutant==		==Solution structure of a Bcl-xL S62E mutant==
	<StructureSection load='6bf2' size='340' side='right' caption='[[6bf2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6bf2' size='340' side='right'caption='[[6bf2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]		*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Follis, A Viacava]]		[[Category: Follis, A Viacava]]
	[[Category: Kriwacki, R W]]		[[Category: Kriwacki, R W]]
	[[Category: Phillips, A]]		[[Category: Phillips, A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 07:11, 28 March 2018

2018-03-28T07:11:20Z

@@ Line 9: / Line 9: @@
 == Function ==
 [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>   Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
 == References ==
 <references/>

OCA at 08:02, 6 December 2017

2017-12-06T08:02:04Z

← Older revision		Revision as of 08:02, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='6bf2' size='340' side='right' caption='[[6bf2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6bf2' size='340' side='right' caption='[[6bf2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [http://pdbe.org/6bf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [http://pdbe.org/6bf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Follis, A Viacava]]		[[Category: Follis, A Viacava]]
	[[Category: Kriwacki, R W]]		[[Category: Kriwacki, R W]]
	[[Category: Phillips, A]]		[[Category: Phillips, A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 07:29, 8 November 2017

2017-11-08T07:29:31Z

← Older revision		Revision as of 07:29, 8 November 2017
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The~~ entry ~~6bf2~~ is ~~ON HOLD~~		==Solution structure of a Bcl-xL S62E mutant==
			<StructureSection load='6bf2' size='340' side='right' caption='[[6bf2]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	~~Authors~~: ~~Viacava Follis~~, A., ~~Phillips~~, A., ~~Kriwacki~~, R.K.		== Structural highlights ==
			<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>
	~~Description~~: ~~Solution structure~~ of a Bcl-~~xL S62E mutant~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [http://pdbe.org/6bf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>
	[[Category: ~~Unreleased Structures~~]]		</table>
	[[Category: Kriwacki, R~~.K]]~~		== Function ==
	~~[[Category: Viacava Follis, A~~]]		[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Follis, A Viacava]]
			[[Category: Kriwacki, R W]]
	[[Category: Phillips, A]]		[[Category: Phillips, A]]
			[[Category: Apoptosis]]

OCA: Protected "6bf2" [edit=sysop:move=sysop]

2017-11-01T05:01:10Z

Protected "6bf2" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:01, 1 November 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6bf2 is ON HOLD Authors: Viacava Follis, A., Phillips, A., Kriwacki, R.K. Description: Solution structure of a Bcl-xL S62E mutant [[Category: Unrel...

2017-11-01T05:01:08Z

New page: '''Unreleased structure''' The entry 6bf2 is ON HOLD Authors: Viacava Follis, A., Phillips, A., Kriwacki, R.K. Description: Solution structure of a Bcl-xL S62E mutant [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6bf2 is ON HOLD

Authors: Viacava Follis, A., Phillips, A., Kriwacki, R.K.

Description: Solution structure of a Bcl-xL S62E mutant
[[Category: Unreleased Structures]]
[[Category: Kriwacki, R.K]]
[[Category: Viacava Follis, A]]
[[Category: Phillips, A]]