6bub - Revision history

OCA at 14:50, 4 October 2023

2023-10-04T14:50:21Z

← Older revision		Revision as of 14:50, 4 October 2023
Line 1:		Line 1:

	==Crystal structure of the PI3KC2alpha PX domain in space group P432==		==Crystal structure of the PI3KC2alpha PX domain in space group P432==
	<StructureSection load='6bub' size='340' side='right' caption='[[6bub]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6bub' size='340' side='right'caption='[[6bub]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bub]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BUB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BUB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.604Å</td></tr>
	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bu0\|6bu0]]~~, [[~~6bty~~\|~~6bty]], [[6btz\|6btz]], [[2iwl\|2iwl~~]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PIK3C2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bub OCA], [https://pdbe.org/6bub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bub RCSB], [https://www.ebi.ac.uk/pdbsum/6bub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bub ProSAT]</span></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4-phosphate_3-kinase Phosphatidylinositol-4-phosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.154 2.7.1.154] </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bub OCA], [~~http~~://pdbe.org/6bub PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bub RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bub PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bub ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/P3C2A_HUMAN P3C2A_HUMAN]] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.<ref>PMID:9337861</ref> <ref>PMID:10766823</ref> <ref>PMID:10805725</ref> <ref>PMID:11239472</ref> <ref>PMID:12719431</ref> <ref>PMID:16215232</ref> <ref>PMID:21081650</ref>		[https://www.uniprot.org/uniprot/P3C2A_HUMAN P3C2A_HUMAN] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.<ref>PMID:9337861</ref> <ref>PMID:10766823</ref> <ref>PMID:10805725</ref> <ref>PMID:11239472</ref> <ref>PMID:12719431</ref> <ref>PMID:16215232</ref> <ref>PMID:21081650</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6bub" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bub" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Phosphatidylinositol-4-phosphate 3-kinase~~]]		[[Category: Large Structures]]
	[[Category: Chen, K E]]		[[Category: Chen K-E]]
	[[Category: Collins~~, B M]]~~		[[Category: Collins BM]]
	~~[[Category: Lipid binding]]~~
	~~[[Category: Phosphoinositide]]~~
	~~[[Category: Pi3-kinase]]~~
	~~[[Category: Px domain]]~~
	~~[[Category: Transferase~~]]

OCA at 08:49, 19 December 2018

2018-12-19T08:49:05Z

← Older revision		Revision as of 08:49, 19 December 2018
Line 3:		Line 3:
	<StructureSection load='6bub' size='340' side='right' caption='[[6bub]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6bub' size='340' side='right' caption='[[6bub]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bub]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BUB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BUB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bu0\|6bu0]], [[6bty\|6bty]], [[6btz\|6btz]], [[2iwl\|2iwl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bu0\|6bu0]], [[6bty\|6bty]], [[6btz\|6btz]], [[2iwl\|2iwl]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4-phosphate_3-kinase Phosphatidylinositol-4-phosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.154 2.7.1.154] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol-4-phosphate_3-kinase Phosphatidylinositol-4-phosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.154 2.7.1.154] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bub OCA], [http://pdbe.org/6bub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bub RCSB], [http://www.ebi.ac.uk/pdbsum/6bub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bub ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bub OCA], [http://pdbe.org/6bub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bub RCSB], [http://www.ebi.ac.uk/pdbsum/6bub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bub ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Phosphatidylinositol-4-phosphate 3-kinase]]		[[Category: Phosphatidylinositol-4-phosphate 3-kinase]]
	[[Category: Chen, K E]]		[[Category: Chen, K E]]

OCA at 07:55, 17 October 2018

2018-10-17T07:55:14Z

@@ Line 1: / Line 1: @@
-The entry 6bub is ON HOLD  until Paper Publication
+==Crystal structure of the PI3KC2alpha PX domain in space group P432==
-Authors: Chen, K.-E., Collins, B.M.
+Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2alpha.,Chen KE, Tillu VA, Chandra M, Collins BM Structure. 2018 Sep 19. pii: S0969-2126(18)30298-3. doi:, 10.1016/j.str.2018.08.010. PMID:30293811<ref>PMID:30293811</ref>
-Description: Crystal structure of the PI3KC2alpha PX domain in space group P432
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Collins, B.M]]
+<div class="pdbe-citations 6bub" style="background-color:#fffaf0;"></div>
-[[Category: Chen, K.-E]]
+== References ==

OCA at 05:33, 14 June 2018

2018-06-14T05:33:26Z

← Older revision		Revision as of 05:33, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6bub is ON HOLD		The entry 6bub is ON HOLD until Paper Publication

	Authors: Chen, K.-E., Collins, B.M.		Authors: Chen, K.-E., Collins, B.M.

OCA at 04:48, 9 May 2018

2018-05-09T04:48:05Z

← Older revision		Revision as of 04:48, 9 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6bub is ON HOLD ~~until Paper Publication~~		The entry 6bub is ON HOLD

	Authors: Chen, K.-E., Collins, B.M.		Authors: Chen, K.-E., Collins, B.M.
Line 7:		Line 7:
	Description: Crystal structure of the PI3KC2alpha PX domain in space group P432		Description: Crystal structure of the PI3KC2alpha PX domain in space group P432
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
			[[Category: Collins, B.M]]
	[[Category: Chen, K.-E]]		[[Category: Chen, K.-E]]
	~~[[Category: Collins, B.M]]~~

OCA at 07:18, 27 December 2017

2017-12-27T07:18:17Z

← Older revision		Revision as of 07:18, 27 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6bub is ON HOLD		The entry 6bub is ON HOLD until Paper Publication

	Authors: Chen, K.-E., Collins, B.M.		Authors: Chen, K.-E., Collins, B.M.

OCA: Protected "6bub" [edit=sysop:move=sysop]

2017-12-20T05:01:32Z

Protected "6bub" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:01, 20 December 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6bub is ON HOLD Authors: Chen, K.-E., Collins, B.M. Description: Crystal structure of the PI3KC2alpha PX domain in space group P432 [[Category: Unr...

2017-12-20T05:01:31Z

New page: '''Unreleased structure''' The entry 6bub is ON HOLD Authors: Chen, K.-E., Collins, B.M. Description: Crystal structure of the PI3KC2alpha PX domain in space group P432 [[Category: Unr...

New page

'''Unreleased structure'''

The entry 6bub is ON HOLD

Authors: Chen, K.-E., Collins, B.M.

Description: Crystal structure of the PI3KC2alpha PX domain in space group P432
[[Category: Unreleased Structures]]
[[Category: Chen, K.-E]]
[[Category: Collins, B.M]]