6csv - Revision history

OCA at 14:30, 13 March 2024

2024-03-13T14:30:22Z

← Older revision		Revision as of 14:30, 13 March 2024
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	<StructureSection load='6csv' size='340' side='right'caption='[[6csv]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6csv' size='340' side='right'caption='[[6csv]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6csv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CSV FirstGlance]. <br>		<table><tr><td colspan='2'>[[6csv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CSV FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csv OCA], [~~http~~://pdbe.org/6csv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6csv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6csv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6csv ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csv OCA], [https://pdbe.org/6csv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6csv RCSB], [https://www.ebi.ac.uk/pdbsum/6csv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6csv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN]] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry.[https://www.uniprot.org/uniprot/CE152_HUMAN CE152_HUMAN] Seckel syndrome;Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN]] Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).<ref>PMID:21406398</ref> <ref>PMID:21983783</ref> <ref>PMID:26297806</ref>		[https://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN] Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).<ref>PMID:21406398</ref> <ref>PMID:21983783</ref> <ref>PMID:26297806</ref> [https://www.uniprot.org/uniprot/CE152_HUMAN CE152_HUMAN] Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.<ref>PMID:21059844</ref> <ref>PMID:20852615</ref> <ref>PMID:21131973</ref>
	~~<div style="background-color~~:~~#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	~~The cell is constructed by higher-order structures and organelles through complex interactions among distinct structural constituents~~. ~~The~~ centrosome is a ~~membraneless organelle composed~~ of ~~two microtubule-derived structures called centrioles~~ and ~~an amorphous mass of pericentriolar material. Super-resolution microscopic analyses~~ in ~~various organisms revealed that diverse pericentriolar material proteins are concentrically localized around a~~ centriole ~~in a highly organized manner~~. ~~However, the molecular nature underlying these organizations remains unknown. Here we show that two human pericentriolar material scaffolds, Cep63 and Cep152, cooperatively generate~~ a ~~heterotetrameric alpha-helical bundle that functions~~ in conjunction with its neighboring hydrophobic motifs to self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4, a key regulator for centriole duplication. Mutations disrupting the self-assembly abrogate Plk4-mediated centriole ~~duplication~~. ~~Because pericentriolar material organization is evolutionarily conserved, this work may offer a paradigm for investigating the assembly and function~~ of ~~centrosomal scaffolds in various organisms.~~

	~~Molecular architecture~~ of ~~a cylindrical self-assembly at human centrosomes~~.,Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS Nat Commun. 2019 Mar 11;10(1):1151. doi: 10.1038/s41467-019-08838-2. PMID:30858376<ref>PMID:~~30858376~~</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.~~<br>
	</~~div~~>
	<~~div class="pdbe-citations 6csv" style="background-color~~:~~#fffaf0;">~~</~~div~~>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ahn~~, J I~~]]		[[Category: Ahn JI]]
	[[Category: Chen, Y]]		[[Category: Chen Y]]
	[[Category: Kim~~, T S~~]]		[[Category: Kim TS]]
	[[Category: Lee, E]]		[[Category: Lee E]]
	[[Category: Lee~~, K S~~]]		[[Category: Lee KS]]
	[[Category: Park~~, J E~~]]		[[Category: Park JE]]
	[[Category: Zhang, L]]		[[Category: Zhang L]]
	~~[[Category: Cell cycle]]~~
	~~[[Category: Centrosome]]~~
	~~[[Category: Complex]]~~
	~~[[Category: Hydrophobic~~]]

OCA at 06:32, 27 March 2019

2019-03-27T06:32:02Z

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-The entry 6csv is ON HOLD  until Paper Publication
+==The structure of the Cep63-Cep152 heterotetrameric complex==
-Authors:
+Molecular architecture of a cylindrical self-assembly at human centrosomes.,Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS Nat Commun. 2019 Mar 11;10(1):1151. doi: 10.1038/s41467-019-08838-2. PMID:30858376<ref>PMID:30858376</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA at 03:58, 20 June 2018

2018-06-20T03:58:19Z

← Older revision		Revision as of 03:58, 20 June 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6csv is ON HOLD		The entry 6csv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6csv" [edit=sysop:move=sysop]

2018-03-28T05:21:47Z

Protected "6csv" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:21, 28 March 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6csv is ON HOLD Authors: Description: Category: Unreleased Structures

2018-03-28T05:21:46Z

New page: '''Unreleased structure''' The entry 6csv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6csv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]