6e4e - Revision history

OCA at 06:18, 11 October 2023

2023-10-11T06:18:29Z

← Older revision		Revision as of 06:18, 11 October 2023
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	<StructureSection load='6e4e' size='340' side='right'caption='[[6e4e]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6e4e' size='340' side='right'caption='[[6e4e]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6e4e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6E4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[6e4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6E4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4e OCA], [~~http~~://pdbe.org/6e4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6e4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6e4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4e OCA], [https://pdbe.org/6e4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6e4e RCSB], [https://www.ebi.ac.uk/pdbsum/6e4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Dihydrofolate reductase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Structural genomic]]~~		[[Category: Staphylococcus aureus]]
	~~[[Category: Dhfr]]~~
	~~[[Category: Folate]]~~
	~~[[Category: Folic acid]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Malaria]]~~
	~~[[Category: Mmv]]~~
	~~[[Category: Niaid]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Oxidoreductase-inhibitor complex]]~~
	~~[[Category: Ssgcid~~]]

OCA at 09:09, 11 November 2020

2020-11-11T09:09:27Z

← Older revision		Revision as of 09:09, 11 November 2020
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	==Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218==		==Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218==
	<StructureSection load='6e4e' size='340' side='right' caption='[[6e4e]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='6e4e' size='340' side='right'caption='[[6e4e]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6e4e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4E OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6E4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[6e4e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E4E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6E4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMV:3-(2-{3-[(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)OXY]PROPOXY}PHENYL)PROPANOIC+ACID'>MMV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4e OCA], [http://pdbe.org/6e4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e4e RCSB], [http://www.ebi.ac.uk/pdbsum/6e4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e4e OCA], [http://pdbe.org/6e4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e4e RCSB], [http://www.ebi.ac.uk/pdbsum/6e4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

			==See Also==
			*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
			[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Dhfr]]		[[Category: Dhfr]]

OCA: Protected "6e4e" [edit=sysop:move=sysop]

2018-07-25T07:21:02Z

Protected "6e4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:21, 25 July 2018
(No difference)

OCA: New page: ==Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218==