6eah - Revision history

OCA at 06:21, 11 October 2023

2023-10-11T06:21:45Z

← Older revision		Revision as of 06:21, 11 October 2023
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	<StructureSection load='6eah' size='340' side='right'caption='[[6eah]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6eah' size='340' side='right'caption='[[6eah]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6eah]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hrsv Hrsv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6eah]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eah OCA], [~~http~~://pdbe.org/6eah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6eah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6eah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6eah ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eah OCA], [https://pdbe.org/6eah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eah RCSB], [https://www.ebi.ac.uk/pdbsum/6eah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eah ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/FUS_HRSVA FUS_HRSVA] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (protein F) interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between host cell and virion membranes. Notably, RSV fusion protein is able to interact directly with heparan sulfate and therefore actively participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.<ref>PMID:12663767</ref> <ref>PMID:18216092</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Hrsv~~]]		[[Category: Human orthopneumovirus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Battles~~, M B~~]]		[[Category: Battles MB]]
	[[Category: McLellan~~, J S]]~~		[[Category: McLellan JS]]
	~~[[Category: Class i viral fusion protein]]~~
	~~[[Category: Fusion]]~~
	~~[[Category: Fusion inhibitor]]~~
	~~[[Category: Prefusion]]~~
	~~[[Category: Respiratory syncytial virus]]~~
	~~[[Category: Viral protein~~]]

OCA at 10:30, 18 December 2019

2019-12-18T10:30:05Z

← Older revision		Revision as of 10:30, 18 December 2019
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	<StructureSection load='6eah' size='340' side='right'caption='[[6eah]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6eah' size='340' side='right'caption='[[6eah]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6eah]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6eah]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsv Hrsv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eah OCA], [http://pdbe.org/6eah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eah RCSB], [http://www.ebi.ac.uk/pdbsum/6eah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eah OCA], [http://pdbe.org/6eah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eah RCSB], [http://www.ebi.ac.uk/pdbsum/6eah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eah ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Hrsv]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Battles, M B]]		[[Category: Battles, M B]]

OCA at 05:46, 7 August 2019

2019-08-07T05:46:56Z

← Older revision		Revision as of 05:46, 7 August 2019
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6eah is ~~ON HOLD until Paper Publication~~		==CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT K394R-S398L STABILIZED IN THE PREFUSION STATE==
			<StructureSection load='6eah' size='340' side='right'caption='[[6eah]], [[Resolution\|resolution]] 3.00Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[6eah]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EAH FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eah OCA], [http://pdbe.org/6eah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eah RCSB], [http://www.ebi.ac.uk/pdbsum/6eah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eah ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Battles, M B]]
			[[Category: McLellan, J S]]
			[[Category: Class i viral fusion protein]]
			[[Category: Fusion]]
			[[Category: Fusion inhibitor]]
			[[Category: Prefusion]]
			[[Category: Respiratory syncytial virus]]
			[[Category: Viral protein]]

OCA at 05:42, 29 August 2018

2018-08-29T05:42:27Z

← Older revision		Revision as of 05:42, 29 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6eah is ON HOLD		The entry 6eah is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6eah" [edit=sysop:move=sysop]

2018-08-09T19:59:02Z

Protected "6eah" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:59, 9 August 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6eah is ON HOLD Authors: Description: Category: Unreleased Structures

2018-08-09T19:59:01Z

New page: '''Unreleased structure''' The entry 6eah is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6eah is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]