6egu - Revision history

OCA at 09:52, 23 October 2024

2024-10-23T09:52:44Z

← Older revision		Revision as of 09:52, 23 October 2024
Line 3:		Line 3:
	<StructureSection load='6egu' size='340' side='right'caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6egu' size='340' side='right'caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rvfv Rvfv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EGU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rift_Valley_fever_virus Rift Valley fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EGU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [~~http~~://pdbe.org/6egu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6egu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [https://pdbe.org/6egu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [https://www.ebi.ac.uk/pdbsum/6egu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GP_RVFV GP_RVFV] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity). Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (PubMed:23319635, PubMed:29097548). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (PubMed:19193794, PubMed:23319635). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (By similarity).[UniProtKB:P09613]<ref>PMID:19193794</ref> <ref>PMID:23319635</ref> <ref>PMID:29097548</ref> Plays a role for virus dissemination in the mosquito.[UniProtKB:P21401]<ref>PMID:24551252</ref> Plays a role for virus dissemination in mosquitoes.[UniProtKB:P21401]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Rvfv~~]]		[[Category: Rift Valley fever virus]]
	[[Category: Guardado-Calvo, P]]		[[Category: Guardado-Calvo P]]
	[[Category: Rey~~, F A]]~~		[[Category: Rey FA]]
	~~[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]~~
	~~[[Category: Viral protein~~]]

OCA at 06:09, 12 June 2019

2019-06-12T06:09:55Z

← Older revision		Revision as of 06:09, 12 June 2019
Line 1:		Line 1:

	==Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine==		==Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine==
	<StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6egu' size='340' side='right'caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Rvfv]]		[[Category: Rvfv]]
	[[Category: ~~GUARDADO~~-~~CALVO~~, P]]		[[Category: Guardado-Calvo, P]]
	[[Category: ~~REY~~, F A]]		[[Category: Rey, F A]]
	[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]		[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 10:19, 15 November 2017

2017-11-15T10:19:04Z

← Older revision		Revision as of 10:19, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [http://pdbe.org/6egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [http://www.ebi.ac.uk/pdbsum/6egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [http://pdbe.org/6egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [http://www.ebi.ac.uk/pdbsum/6egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. The GPL head-group recognition pocket is conserved in the fusion proteins of other arthropod-borne viruses, such as Zika and chikungunya viruses, which have recently caused major epidemics worldwide.

			A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.,Guardado-Calvo P, Atkovska K, Jeffers SA, Grau N, Backovic M, Perez-Vargas J, de Boer SM, Tortorici MA, Pehau-Arnaudet G, Lepault J, England P, Rottier PJ, Bosch BJ, Hub JS, Rey FA Science. 2017 Nov 3;358(6363):663-667. doi: 10.1126/science.aal2712. PMID:29097548<ref>PMID:29097548</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6egu" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Rvfv]]
	[[Category: GUARDADO-CALVO, P]]		[[Category: GUARDADO-CALVO, P]]
	[[Category: REY, F A]]		[[Category: REY, F A]]
	[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]		[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 06:34, 1 November 2017

2017-11-01T06:34:44Z

← Older revision		Revision as of 06:34, 1 November 2017
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry 6egu is ON HOLD until Sep 12 2019~~		==Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine==
			<StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution\|resolution]] 2.30Å' scene=''>
	~~Authors: GUARDADO-CALVO, P., REY, F.A.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[6egu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br>
	~~Description:~~ Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [http://pdbe.org/6egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [http://www.ebi.ac.uk/pdbsum/6egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr>
	[[Category: ~~Guardado~~-~~Calvo~~, P]]		</table>
	[[Category: ~~Rey~~, F.A]]		__TOC__
			</StructureSection>
			[[Category: GUARDADO-CALVO, P]]
			[[Category: REY, F A]]
			[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]]
			[[Category: Viral protein]]

OCA: Protected "6egu" [edit=sysop:move=sysop]

2017-09-27T17:09:00Z

Protected "6egu" [edit=sysop:move=sysop]

← Older revision	Revision as of 17:09, 27 September 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6egu is ON HOLD until Sep 12 2019 Authors: GUARDADO-CALVO, P., REY, F.A. Description: Structure of RVFV envelope protein Gc in postfusion conformat...

2017-09-27T17:08:59Z

New page: '''Unreleased structure''' The entry 6egu is ON HOLD until Sep 12 2019 Authors: GUARDADO-CALVO, P., REY, F.A. Description: Structure of RVFV envelope protein Gc in postfusion conformat...

New page

'''Unreleased structure'''

The entry 6egu is ON HOLD until Sep 12 2019

Authors: GUARDADO-CALVO, P., REY, F.A.

Description: Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine
[[Category: Unreleased Structures]]
[[Category: Guardado-Calvo, P]]
[[Category: Rey, F.A]]