6emo - Revision history

OCA at 06:04, 19 June 2024

2024-06-19T06:04:29Z

← Older revision		Revision as of 06:04, 19 June 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [https://pdbe.org/6emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [https://www.ebi.ac.uk/pdbsum/6emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [https://pdbe.org/6emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [https://www.ebi.ac.uk/pdbsum/6emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 10:43, 14 June 2023

2023-06-14T10:43:51Z

← Older revision		Revision as of 10:43, 14 June 2023
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	==Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex==		==Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex==
	<StructureSection load='6emo' size='340' side='right'caption='[[6emo~~]], [[NMR_Ensembles_of_Models \| 40 NMR models~~]]' scene=''>		<StructureSection load='6emo' size='340' side='right'caption='[[6emo]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EMO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSIP1, DFS70, LEDGF, PSIP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [https://pdbe.org/6emo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [https://www.ebi.ac.uk/pdbsum/6emo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [~~http~~://pdbe.org/6emo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6emo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.		[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>		[https://www.uniprot.org/uniprot/CDA7L_HUMAN CDA7L_HUMAN] Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.<ref>PMID:15654081</ref> <ref>PMID:15994933</ref> <ref>PMID:16829576</ref> [https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Veverka, V]]		[[Category: Veverka V]]
	~~[[Category: Epigenetic]]~~
	~~[[Category: Leukemia]]~~
	~~[[Category: Protein-protein complex]]~~
	~~[[Category: Transcription~~]]

OCA at 13:24, 10 May 2019

2019-05-10T13:24:14Z

← Older revision		Revision as of 13:24, 10 May 2019
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	==Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex==		==Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex==
	<StructureSection load='6emo' size='340' side='right' caption='[[6emo]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>		<StructureSection load='6emo' size='340' side='right'caption='[[6emo]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EMO FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Veverka, V]]		[[Category: Veverka, V]]
	[[Category: Epigenetic]]		[[Category: Epigenetic]]

OCA at 19:09, 1 August 2018

2018-08-01T19:09:38Z

← Older revision		Revision as of 19:09, 1 August 2018
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	<StructureSection load='6emo' size='340' side='right' caption='[[6emo]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>		<StructureSection load='6emo' size='340' side='right' caption='[[6emo]], [[NMR_Ensembles_of_Models \| 40 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6emo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EMO FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [http://pdbe.org/6emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [http://www.ebi.ac.uk/pdbsum/6emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PSIP1, DFS70, LEDGF, PSIP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6emo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emo OCA], [http://pdbe.org/6emo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6emo RCSB], [http://www.ebi.ac.uk/pdbsum/6emo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6emo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Veverka, V]]		[[Category: Veverka, V]]
	[[Category: Epigenetic]]		[[Category: Epigenetic]]

OCA at 07:21, 25 July 2018

2018-07-25T07:21:24Z

@@ Line 1: / Line 1: @@
-The entry 6emo is ON HOLD  until sometime in the future
+==Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex==
-Authors:
+Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.,Sharma S, Cermakova K, De Rijck J, Demeulemeester J, Fabry M, El Ashkar S, Van Belle S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, Veverka V Proc Natl Acad Sci U S A. 2018 Jul 11. pii: 1803909115. doi:, 10.1073/pnas.1803909115. PMID:29997176<ref>PMID:29997176</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "6emo" [edit=sysop:move=sysop]

2017-10-11T05:44:05Z

Protected "6emo" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:44, 11 October 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6emo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

2017-10-11T05:44:03Z

New page: '''Unreleased structure''' The entry 6emo is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6emo is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]