6ext - Revision history

OCA at 09:54, 23 October 2024

2024-10-23T09:54:00Z

← Older revision		Revision as of 09:54, 23 October 2024
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	==Crystal structure of the DNA binding domain of fission yeast Sap1==		==Crystal structure of the DNA binding domain of fission yeast Sap1==
	<StructureSection load='6ext' size='340' side='right' caption='[[6ext]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='6ext' size='340' side='right'caption='[[6ext]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ext]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6EXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ext]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EXT FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~sap1, SPCC1672.02c ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ext FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ext OCA], [~~http~~://pdbe.org/6ext PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ext RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ext PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ext ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ext FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ext OCA], [https://pdbe.org/6ext PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ext RCSB], [https://www.ebi.ac.uk/pdbsum/6ext PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ext ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SAP1_SCHPO SAP1_SCHPO]] Binds to sequences required for mating-type switching. Makes a simultaneous contact with both the alpha and beta domains of the switch-activating site SAS1. Also binds to replication fork barrier 1 (RFB1) located within a 78 base pair sequence near the 3' end of the rRNA coding region. This leads to replication fork blockage. It binds the consensus sequence 5'-TA[AG]GCAGNTN[CT]AACG[AC]G-3'. Has a role in chromosome organization and integrity where it is involved in chromosome segregation. Has a role in sister chromatid cohesion and condensation.		[https://www.uniprot.org/uniprot/SAP1_SCHPO SAP1_SCHPO] Binds to sequences required for mating-type switching. Makes a simultaneous contact with both the alpha and beta domains of the switch-activating site SAS1. Also binds to replication fork barrier 1 (RFB1) located within a 78 base pair sequence near the 3' end of the rRNA coding region. This leads to replication fork blockage. It binds the consensus sequence 5'-TA[AG]GCAGNTN[CT]AACG[AC]G-3'. Has a role in chromosome organization and integrity where it is involved in chromosome segregation. Has a role in sister chromatid cohesion and condensation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Fission yeast~~]]		[[Category: Large Structures]]
	[[Category: ~~Ekundayo, B~~]]		[[Category: Schizosaccharomyces pombe 972h-]]
	[[Category: ~~Joergensen, M~~]]		[[Category: Ekundayo B]]
	[[Category: ~~Schalch, T~~]]		[[Category: Joergensen M]]
	[[Category: ~~Dna binding protein]]~~		[[Category: Schalch T]]
	~~[[Category: Dna replication]]~~
	~~[[Category: Mating type switch]]~~
	~~[[Category: Myb domain]]~~
	~~[[Category: S. pombe~~]]

OCA at 20:29, 2 December 2018

2018-12-02T20:29:31Z

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-The entry 6ext is ON HOLD  until Paper Publication
+==Crystal structure of the DNA binding domain of fission yeast Sap1==
-Authors: Ekundayo, B., Joergensen, M., Schalch, T.
+Structure of the replication regulator Sap1 reveals functionally important interfaces.,Jorgensen MM, Ekundayo B, Zaratiegui M, Skriver K, Thon G, Schalch T Sci Rep. 2018 Jul 19;8(1):10930. doi: 10.1038/s41598-018-29198-9. PMID:30026545<ref>PMID:30026545</ref>
-Description: Crystal structure of the DNA binding domain of fission yeast Sap1
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Schalch, T]]
+<div class="pdbe-citations 6ext" style="background-color:#fffaf0;"></div>
 [[Category: Ekundayo, B]]
 [[Category: Joergensen, M]]

OCA at 05:11, 29 November 2017

2017-11-29T05:11:46Z

← Older revision		Revision as of 05:11, 29 November 2017
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	The entry 6ext is ON HOLD until Paper Publication		The entry 6ext is ON HOLD until Paper Publication

	Authors: Ekundayo, B., ~~Schalch~~, T., ~~Joergensen~~, M.		Authors: Ekundayo, B., Joergensen, M., Schalch, T.

	Description: Crystal structure of the DNA binding domain of fission yeast Sap1		Description: Crystal structure of the DNA binding domain of fission yeast Sap1

OCA at 06:40, 22 November 2017

2017-11-22T06:40:52Z

← Older revision		Revision as of 06:40, 22 November 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6ext is ON HOLD		The entry 6ext is ON HOLD until Paper Publication

	Authors: Ekundayo, B., Schalch, T.		Authors: Ekundayo, B., Schalch, T., Joergensen, M.

	Description: Crystal structure of the DNA binding domain of fission yeast Sap1		Description: Crystal structure of the DNA binding domain of fission yeast Sap1
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	[[Category: Schalch, T]]		[[Category: Schalch, T]]
	[[Category: Ekundayo, B]]		[[Category: Ekundayo, B]]
			[[Category: Joergensen, M]]

OCA: Protected "6ext" [edit=sysop:move=sysop]

2017-11-15T06:32:26Z

Protected "6ext" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:32, 15 November 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6ext is ON HOLD Authors: Ekundayo, B., Schalch, T. Description: Crystal structure of the DNA binding domain of fission yeast Sap1 [[Category: Unrel...

2017-11-15T06:32:25Z

New page: '''Unreleased structure''' The entry 6ext is ON HOLD Authors: Ekundayo, B., Schalch, T. Description: Crystal structure of the DNA binding domain of fission yeast Sap1 [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6ext is ON HOLD

Authors: Ekundayo, B., Schalch, T.

Description: Crystal structure of the DNA binding domain of fission yeast Sap1
[[Category: Unreleased Structures]]
[[Category: Schalch, T]]
[[Category: Ekundayo, B]]