6fbb - Revision history

OCA at 09:54, 23 October 2024

2024-10-23T09:54:56Z

← Older revision		Revision as of 09:54, 23 October 2024
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	==Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3==		==Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3==
	<StructureSection load='6fbb' size='340' side='right' caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6fbb' size='340' side='right'caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FBB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [~~http~~://pdbe.org/6fbb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [https://pdbe.org/6fbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [https://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.		[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6fbb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fbb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Leysen, S~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Meijer, F A~~]]		[[Category: Large Structures]]
	[[Category: ~~Milroy, L G~~]]		[[Category: Leysen S]]
	[[Category: ~~Ottmann, C~~]]		[[Category: Meijer FA]]
	[[Category: ~~Complex~~]]		[[Category: Milroy LG]]
	[[Category: ~~Peptide binding protein~~]]		[[Category: Ottmann C]]

OCA at 06:35, 9 May 2018

2018-05-09T06:35:45Z

← Older revision		Revision as of 06:35, 9 May 2018
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	<StructureSection load='6fbb' size='340' side='right' caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6fbb' size='340' side='right' caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [http://pdbe.org/6fbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [http://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [http://pdbe.org/6fbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [http://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Leysen, S]]		[[Category: Leysen, S]]
	[[Category: Meijer, F A]]		[[Category: Meijer, F A]]

OCA at 07:21, 28 March 2018

2018-03-28T07:21:08Z

← Older revision		Revision as of 07:21, 28 March 2018
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	<StructureSection load='6fbb' size='340' side='right' caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='6fbb' size='340' side='right' caption='[[6fbb]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [http://pdbe.org/6fbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [http://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fbb OCA], [http://pdbe.org/6fbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fbb RCSB], [http://www.ebi.ac.uk/pdbsum/6fbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fbb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Leysen, S]]		[[Category: Leysen, S]]
	[[Category: Meijer, F A]]		[[Category: Meijer, F A]]

OCA at 06:34, 14 March 2018

2018-03-14T06:34:21Z

@@ Line 1: / Line 1: @@
-The entry 6fbb is ON HOLD
+==Crystal structure of 14-3-3 sigma in complex with wild-type Shroom3==
-Authors:
+Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.,Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J J Am Soc Nephrol. 2018 Feb 23. pii: ASN.2017080856. doi: 10.1681/ASN.2017080856. PMID:29476007<ref>PMID:29476007</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "6fbb" [edit=sysop:move=sysop]

2017-12-27T07:31:30Z

Protected "6fbb" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:31, 27 December 2017
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6fbb is ON HOLD Authors: Description: Category: Unreleased Structures

2017-12-27T07:31:29Z

New page: '''Unreleased structure''' The entry 6fbb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6fbb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]