6fpg - Revision history

OCA at 12:38, 6 November 2024

2024-11-06T12:38:41Z

← Older revision		Revision as of 12:38, 6 November 2024
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	==Structure of the Ustilago maydis chorismate mutase 1 in complex with a Zea mays kiwellin==		==Structure of the Ustilago maydis chorismate mutase 1 in complex with a Zea mays kiwellin==
	<StructureSection load='6fpg' size='340' side='right' caption='[[6fpg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6fpg' size='340' side='right'caption='[[6fpg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fpg]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Corn_smut_fungus Corn smut fungus~~] and [~~http~~://en.wikipedia.org/wiki/~~Maize Maize~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fpg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ustilago_maydis_521 Ustilago maydis 521] and [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FPG FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CIT:CITRIC+ACID'>CIT</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~UMAG_05731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=237631 Corn smut fungus]), 103626138, ZEAMMB73_Zm00001d013945 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 MAIZE])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpg OCA], [~~http~~://pdbe.org/6fpg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fpg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fpg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpg OCA], [https://pdbe.org/6fpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fpg RCSB], [https://www.ebi.ac.uk/pdbsum/6fpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpg ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CMU1_USTMA CMU1_USTMA] Secreted chorismate mutase that is one component of a cocktail of effectors shaping the host metabolome and acting as virulence factors. The enzyme is taken up by plant cells, can spread to neighboring cells where it affects the biosynthesis of the plant immune signal salicylic acid by channelling chorismate into the phenylpropanoid pathway (PubMed:21976020, PubMed:30651637). Interferes with the activity of host cytosolic chorismate mutase CM2 through heterodimerization (PubMed:21976020).<ref>PMID:21976020</ref> <ref>PMID:30651637</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Corn smut fungus~~]]		[[Category: Large Structures]]
	[[Category: ~~Maize~~]]		[[Category: Ustilago maydis 521]]
	[[Category: ~~Altegoer, F~~]]		[[Category: Zea mays]]
	[[Category: ~~Bange, G~~]]		[[Category: Altegoer F]]
	[[Category: ~~Steinchen, W~~]]		[[Category: Bange G]]
	[[Category: ~~Cell invasion]]~~		[[Category: Steinchen W]]
	~~[[Category: Chorismate]]~~
	~~[[Category: Kiwellin]]~~
	~~[[Category: Smut disease~~]]

OCA at 09:27, 30 January 2019

2019-01-30T09:27:48Z

← Older revision		Revision as of 09:27, 30 January 2019
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	<StructureSection load='6fpg' size='340' side='right' caption='[[6fpg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6fpg' size='340' side='right' caption='[[6fpg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fpg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FPG FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fpg]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Corn_smut_fungus Corn smut fungus] and [http://en.wikipedia.org/wiki/Maize Maize]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FPG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UMAG_05731 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237631 Corn smut fungus]), 103626138, ZEAMMB73_Zm00001d013945 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 MAIZE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpg OCA], [http://pdbe.org/6fpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fpg RCSB], [http://www.ebi.ac.uk/pdbsum/6fpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpg OCA], [http://pdbe.org/6fpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fpg RCSB], [http://www.ebi.ac.uk/pdbsum/6fpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpg ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Fungi-induced plant diseases affect global food security and plant ecology. The biotrophic fungus Ustilago maydis causes smut disease in maize (Zea mays) plants by secreting numerous virulence effectors that reprogram plant metabolism and immune responses(1,2). The secreted fungal chorismate mutase Cmu1 presumably affects biosynthesis of the plant immune signal salicylic acid by channelling chorismate into the phenylpropanoid pathway(3). Here we show that one of the 20 maize-encoded kiwellins (ZmKWL1) specifically blocks the catalytic activity of Cmu1. ZmKWL1 hinders substrate access to the active site of Cmu1 through intimate interactions involving structural features that are specific to fungal Cmu1 orthologues. Phylogenetic analysis suggests that plant kiwellins have a versatile scaffold that can specifically counteract pathogen effectors such as Cmu1. We reveal the biological activity of a member of the kiwellin family, a widely conserved group of proteins that have previously been recognized only as important human allergens.

			A kiwellin disarms the metabolic activity of a secreted fungal virulence factor.,Han X, Altegoer F, Steinchen W, Binnebesel L, Schuhmacher J, Glatter T, Giammarinaro PI, Djamei A, Rensing SA, Reissmann S, Kahmann R, Bange G Nature. 2019 Jan 16. pii: 10.1038/s41586-018-0857-9. doi:, 10.1038/s41586-018-0857-9. PMID:30651637<ref>PMID:30651637</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6fpg" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Corn smut fungus]]
			[[Category: Maize]]
	[[Category: Altegoer, F]]		[[Category: Altegoer, F]]
	[[Category: Bange, G]]		[[Category: Bange, G]]

OCA at 12:07, 16 January 2019

2019-01-16T12:07:17Z

← Older revision		Revision as of 12:07, 16 January 2019
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6fpg is ~~ON HOLD until Paper Publication~~		==Structure of the Ustilago maydis chorismate mutase 1 in complex with a Zea mays kiwellin==
			<StructureSection load='6fpg' size='340' side='right' caption='[[6fpg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	~~Authors~~: ~~Altegoer~~, F., ~~Steinchen~~, W., ~~Bange~~, G.		== Structural highlights ==
			<table><tr><td colspan='2'>[[6fpg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FPG FirstGlance]. <br>
	~~Description: Structure of the Ustilago maydis chorismate mutase 1 in complex with a Zea mays kiwellin~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fpg OCA], [http://pdbe.org/6fpg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fpg RCSB], [http://www.ebi.ac.uk/pdbsum/6fpg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fpg ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Altegoer, F]]
	[[Category: Bange, G]]		[[Category: Bange, G]]
	~~[[Category: Altegoer, F]]~~
	[[Category: Steinchen, W]]		[[Category: Steinchen, W]]
			[[Category: Cell invasion]]
			[[Category: Chorismate]]
			[[Category: Kiwellin]]
			[[Category: Smut disease]]

OCA: Protected "6fpg" [edit=sysop:move=sysop]

2018-02-28T05:08:51Z

Protected "6fpg" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:08, 28 February 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6fpg is ON HOLD until Paper Publication Authors: Altegoer, F., Steinchen, W., Bange, G. Description: Structure of the Ustilago maydis chorismate mu...

2018-02-28T05:08:50Z

New page: '''Unreleased structure''' The entry 6fpg is ON HOLD until Paper Publication Authors: Altegoer, F., Steinchen, W., Bange, G. Description: Structure of the Ustilago maydis chorismate mu...

New page

'''Unreleased structure'''

The entry 6fpg is ON HOLD until Paper Publication

Authors: Altegoer, F., Steinchen, W., Bange, G.

Description: Structure of the Ustilago maydis chorismate mutase 1 in complex with a Zea mays kiwellin
[[Category: Unreleased Structures]]
[[Category: Bange, G]]
[[Category: Altegoer, F]]
[[Category: Steinchen, W]]