6fty - Revision history

OCA at 09:01, 9 October 2024

2024-10-09T09:01:02Z

← Older revision		Revision as of 09:01, 9 October 2024
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	==COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5==		==COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5==
	<StructureSection load='6fty' size='340' side='right' caption='[[6fty]], [[Resolution\|resolution]] 1.67Å' scene=''>		<StructureSection load='6fty' size='340' side='right'caption='[[6fty]], [[Resolution\|resolution]] 1.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6fty]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FTY FirstGlance]. <br>		<table><tr><td colspan='2'>[[6fty]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FTY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7H:4-[[(5~{S},7~{R})-3-azanyl-1-adamantyl]carbonylamino]-1~{H}-indole-2-carboxamide'>E7H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.67Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_factor_D Complement factor D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.46 3.4.21.46] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E7H:4-[[(5~{S},7~{R})-3-azanyl-1-adamantyl]carbonylamino]-1~{H}-indole-2-carboxamide'>E7H</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fty OCA], [~~http~~://pdbe.org/6fty PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6fty RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6fty PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6fty ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fty OCA], [https://pdbe.org/6fty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fty RCSB], [https://www.ebi.ac.uk/pdbsum/6fty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fty ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[~~http~~://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.		[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[https://omim.org/entry/613912 613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.		[https://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6fty" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6fty" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Complement factor 3D structures\|Complement factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Complement factor D~~]]		[[Category: Homo sapiens]]
	[[Category: ~~Ostermann, N~~]]		[[Category: Large Structures]]
	[[Category: ~~Hydrolase]]~~		[[Category: Ostermann N]]
	~~[[Category: Serine protease~~]]

OCA at 06:01, 6 June 2018

2018-06-06T06:01:37Z

@@ Line 1: / Line 1: @@
-The entry 6fty is ON HOLD  until Paper Publication
+==COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5==
-Authors: Ostermann, N.
+Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.,Vulpetti A, Ostermann N, Randl S, Yoon T, Mac Sweeney A, Cumin F, Lorthiois E, Rudisser S, Erbel P, Maibaum J ACS Med Chem Lett. 2018 Apr 24;9(5):490-495. doi: 10.1021/acsmedchemlett.8b00104., eCollection 2018 May 10. PMID:29795765<ref>PMID:29795765</ref>
-Description: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
 [[Category: Ostermann, N]]

OCA: Protected "6fty" [edit=sysop:move=sysop]

2018-03-08T03:56:23Z

Protected "6fty" [edit=sysop:move=sysop]

← Older revision	Revision as of 03:56, 8 March 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6fty is ON HOLD until Paper Publication Authors: Ostermann, N. Description: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5 [[Category: Unreleased St...

2018-03-08T03:56:22Z

New page: '''Unreleased structure''' The entry 6fty is ON HOLD until Paper Publication Authors: Ostermann, N. Description: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5 [[Category: Unreleased St...

New page

'''Unreleased structure'''

The entry 6fty is ON HOLD until Paper Publication

Authors: Ostermann, N.

Description: COMPLEMENT FACTOR D COMPLEXED WITH COMPOUND 5
[[Category: Unreleased Structures]]
[[Category: Ostermann, N]]