6imo - Revision history

OCA at 09:46, 22 November 2023

2023-11-22T09:46:12Z

← Older revision		Revision as of 09:46, 22 November 2023
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	<StructureSection load='6imo' size='340' side='right'caption='[[6imo]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6imo' size='340' side='right'caption='[[6imo]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6imo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IMO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6IMO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6imo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IMO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AJL:(1S)-1-[(1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde'>AJL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJL:(1S)-1-[(1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde'>AJL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6imo OCA], [~~http~~://pdbe.org/6imo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6imo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6imo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6imo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6imo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6imo OCA], [https://pdbe.org/6imo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6imo RCSB], [https://www.ebi.ac.uk/pdbsum/6imo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6imo ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[~~http~~://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>		[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>		[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6imo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6imo" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~3',5'-cyclic-AMP phosphodiesterase~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Su~~, H X~~]]		[[Category: Su HX]]
	[[Category: Xu~~, Y C~~]]		[[Category: Xu YC]]
	[[Category: Zhang~~, X L]]~~		[[Category: Zhang XL]]
	~~[[Category: Complex]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Pde4d~~]]

OCA at 06:47, 23 October 2019

2019-10-23T06:47:38Z

@@ Line 1: / Line 1: @@
-The entry 6imo is ON HOLD  until Paper Publication
+==Crystal structure of PDE4D complexed with a novel inhibitor==
-Authors: Zhang, X.L., Su, H.X., Xu, Y.C.
+Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.,Zhang X, Dong G, Li H, Chen W, Li J, Feng C, Gu Z, Zhu F, Zhang R, Li M, Tang W, Liu H, Xu Y J Med Chem. 2019 Jun 13;62(11):5579-5593. doi: 10.1021/acs.jmedchem.9b00518. Epub, 2019 May 31. PMID:31099559<ref>PMID:31099559</ref>
-Description: Crystal structure of PDE4D complexed with a novel inhibitor
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Su, H.X]]
+<div class="pdbe-citations 6imo" style="background-color:#fffaf0;"></div>
-[[Category: Zhang, X.L]]
+== References ==
-[[Category: Xu, Y.C]]
+<references/>

OCA at 09:54, 13 March 2019

2019-03-13T09:54:07Z

← Older revision		Revision as of 09:54, 13 March 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6imo is ON HOLD		The entry 6imo is ON HOLD until Paper Publication

	Authors: Zhang, X.L., Su, H.X., Xu, Y.C.		Authors: Zhang, X.L., Su, H.X., Xu, Y.C.

OCA: Protected "6imo" [edit=sysop:move=sysop]

2018-10-31T05:22:04Z

Protected "6imo" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:22, 31 October 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6imo is ON HOLD Authors: Zhang, X.L., Su, H.X., Xu, Y.C. Description: Crystal structure of PDE4D complexed with a novel inhibitor [[Category: Unrel...

2018-10-31T05:22:03Z

New page: '''Unreleased structure''' The entry 6imo is ON HOLD Authors: Zhang, X.L., Su, H.X., Xu, Y.C. Description: Crystal structure of PDE4D complexed with a novel inhibitor [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 6imo is ON HOLD

Authors: Zhang, X.L., Su, H.X., Xu, Y.C.

Description: Crystal structure of PDE4D complexed with a novel inhibitor
[[Category: Unreleased Structures]]
[[Category: Su, H.X]]
[[Category: Zhang, X.L]]
[[Category: Xu, Y.C]]