6irc - Revision history

OCA at 09:06, 9 April 2025

2025-04-09T09:06:03Z

← Older revision		Revision as of 09:06, 9 April 2025
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	<StructureSection load='6irc' size='340' side='right'caption='[[6irc]], [[Resolution\|resolution]] 3.54Å' scene=''>		<StructureSection load='6irc' size='340' side='right'caption='[[6irc]], [[Resolution\|resolution]] 3.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6IRC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IRC FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.538Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">norpA, PLC-beta, CG3620 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=7227 DROME])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11]~~ </~~span~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [https://pdbe.org/6irc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [https://www.ebi.ac.uk/pdbsum/6irc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [~~http~~://pdbe.org/6irc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6irc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>		[https://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drome~~]]		[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Phosphoinositide phospholipase C]]~~		[[Category: Huang Y]]
	[[Category: Huang, Y]]		[[Category: Li J]]
	[[Category: Li, J]]		[[Category: Liu W]]
	[[Category: Liu, W]]		[[Category: Ye F]]
	[[Category: Ye, F]]		[[Category: Zhang M]]
	[[Category: Zhang, M]]
	~~[[Category: Coiled coil]]~~
	~~[[Category: Drosophila]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Phospholipase beta~~]]

OCA at 20:39, 28 October 2020

2020-10-28T20:39:34Z

← Older revision		Revision as of 20:39, 28 October 2020
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	==C-terminal domain of Drosophila phospholipase b NORPA, methylated==		==C-terminal domain of Drosophila phospholipase b NORPA, methylated==
	<StructureSection load='6irc' size='340' side='right' caption='[[6irc]], [[Resolution\|resolution]] 3.54Å' scene=''>		<StructureSection load='6irc' size='340' side='right'caption='[[6irc]], [[Resolution\|resolution]] 3.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=6IRC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6IRC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">norpA, PLC-beta, CG3620 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [http://pdbe.org/6irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [http://www.ebi.ac.uk/pdbsum/6irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [http://pdbe.org/6irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [http://www.ebi.ac.uk/pdbsum/6irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>		[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cbeta, PLCbeta), a key step for the fast kinetics of the light signaling, is not known. Here, we show that the NORPA C-terminal coiled-coil domain and PDZ-binding motif (CC-PBM) synergistically bind to INAD PDZ45 tandem with an unexpected mode and unprecedented high affinity. Guided by the structure of the INAD-NORPA complex, we discover that INADL is probably a mammalian counterpart of INAD. The INADL PDZ89 tandem specifically binds to PLCbeta4 with a mode that is strikingly similar to that of the INAD-NORPA complex, as revealed by the structure of the INADL PDZ89-PLCbeta4 CC-PBM complex. Therefore, our study suggests that the highly specific PDZ tandem - PLCbeta interactions are an evolutionarily conserved mechanism in PLCbeta signaling in the animal kingdom.

			An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors.,Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M Elife. 2018 Dec 10;7. pii: 41848. doi: 10.7554/eLife.41848. PMID:30526850<ref>PMID:30526850</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6irc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Drome]]
			[[Category: Large Structures]]
	[[Category: Phosphoinositide phospholipase C]]		[[Category: Phosphoinositide phospholipase C]]
	[[Category: Huang, Y]]		[[Category: Huang, Y]]

OCA at 06:12, 2 January 2019

2019-01-02T06:12:28Z

← Older revision		Revision as of 06:12, 2 January 2019
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6irc is ~~ON HOLD until Paper Publication~~		==C-terminal domain of Drosophila phospholipase b NORPA, methylated==
			<StructureSection load='6irc' size='340' side='right' caption='[[6irc]], [[Resolution\|resolution]] 3.54Å' scene=''>
	~~Authors~~: Ye, F., Li, J., ~~Huang~~, Y., ~~Liu, W~~.~~, Zhang, M~~.		== Structural highlights ==
			<table><tr><td colspan='2'>[[6irc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IRC FirstGlance]. <br>
	~~Description~~: C-~~terminal domain~~ of ~~Drosophila~~ phospholipase ~~b NORPA, methylated~~		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
	[[Category: ~~Zhang~~, M]]		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6irc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6irc OCA], [http://pdbe.org/6irc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6irc RCSB], [http://www.ebi.ac.uk/pdbsum/6irc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6irc ProSAT]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PIPA_DROME PIPA_DROME]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).[UniProtKB:Q9P212]<ref>PMID:2457447</ref> <ref>PMID:25639794</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Phosphoinositide phospholipase C]]
			[[Category: Huang, Y]]
			[[Category: Li, J]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
	[[Category: Ye, F]]		[[Category: Ye, F]]
	[[Category: Li, J]]		[[Category: Zhang, M]]
	[[Category: ~~Huang, Y~~]]		[[Category: Coiled coil]]
			[[Category: Drosophila]]
			[[Category: Hydrolase]]
			[[Category: Phospholipase beta]]

OCA at 06:35, 26 December 2018

2018-12-26T06:35:53Z

← Older revision		Revision as of 06:35, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6irc is ON HOLD		The entry 6irc is ON HOLD until Paper Publication

	Authors: Ye, F., Li, J., Liu, Z., Zhang, M.		Authors: Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.

	Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated		Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	~~[[Category: Li, J]]~~
	[[Category: Zhang, M]]		[[Category: Zhang, M]]
	[[Category: Liu, Z]]		[[Category: Liu, W]]
	[[Category: Ye, F]]		[[Category: Ye, F]]
			[[Category: Li, J]]
			[[Category: Huang, Y]]

OCA: Protected "6irc" [edit=sysop:move=sysop]

2018-12-02T18:53:04Z

Protected "6irc" [edit=sysop:move=sysop]

← Older revision	Revision as of 18:53, 2 December 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6irc is ON HOLD Authors: Ye, F., Li, J., Liu, Z., Zhang, M. Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated [[Catego...

2018-12-02T18:53:02Z

New page: '''Unreleased structure''' The entry 6irc is ON HOLD Authors: Ye, F., Li, J., Liu, Z., Zhang, M. Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated [[Catego...

New page

'''Unreleased structure'''

The entry 6irc is ON HOLD

Authors: Ye, F., Li, J., Liu, Z., Zhang, M.

Description: C-terminal domain of Drosophila phospholipase b NORPA, methylated
[[Category: Unreleased Structures]]
[[Category: Li, J]]
[[Category: Zhang, M]]
[[Category: Liu, Z]]
[[Category: Ye, F]]