6jvb - Revision history

OCA at 10:20, 22 November 2023

2023-11-22T10:20:22Z

← Older revision		Revision as of 10:20, 22 November 2023
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	<StructureSection load='6jvb' size='340' side='right'caption='[[6jvb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6jvb' size='340' side='right'caption='[[6jvb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6jvb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6jvb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JVB FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DPYSL2~~, ~~CRMP2, ULIP2 (~~[~~http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5~~&~~id=9606 HUMAN])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvb OCA], [~~http~~://pdbe.org/6jvb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jvb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jvb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvb OCA], [https://pdbe.org/6jvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jvb RCSB], [https://www.ebi.ac.uk/pdbsum/6jvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN]] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>		[https://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa N]]
	[[Category: Jiang, X]]		[[Category: Jiang X]]
	[[Category: Ogawa, T]]		[[Category: Ogawa T]]
	~~[[Category: Gap activity]]~~
	~~[[Category: Microtubule associated protein]]~~
	~~[[Category: Neuronal protein]]~~
	~~[[Category: Structural protein~~]]

OCA at 07:57, 23 October 2019

2019-10-23T07:57:12Z

← Older revision		Revision as of 07:57, 23 October 2019
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	<StructureSection load='6jvb' size='340' side='right'caption='[[6jvb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6jvb' size='340' side='right'caption='[[6jvb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6jvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JVB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6jvb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JVB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvb OCA], [http://pdbe.org/6jvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvb RCSB], [http://www.ebi.ac.uk/pdbsum/6jvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvb ProSAT]</span></td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPYSL2, CRMP2, ULIP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvb OCA], [http://pdbe.org/6jvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvb RCSB], [http://www.ebi.ac.uk/pdbsum/6jvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN]] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>		[[http://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN]] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (GLO1), a crucial enzyme for the clearance of carbonyl stress, was disrupted. The iPS cells exhibited significant cellular and developmental deficits, and hyper-carbonylation of collapsing response mediator protein 2 (CRMP2). Structural and biochemical analyses revealed an array of multiple carbonylation sites in the functional motifs of CRMP2, particularly D-hook (for dimerization) and T-site (for tetramerization), which are critical for the activity of the CRMP2 tetramer. Interestingly, carbonylated CRMP2 was stacked in the multimer conformation by irreversible cross-linking, resulting in loss of its unique function to bundle microtubules. Thus, the present study revealed that the enhanced carbonyl stress stemmed from the genetic aberrations results in neurodevelopmental deficits through the formation of irreversible dysfunctional multimer of carbonylated CRMP2.

			Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.,Toyoshima M, Jiang X, Ogawa T, Ohnishi T, Yoshihara S, Balan S, Yoshikawa T, Hirokawa N Life Sci Alliance. 2019 Oct 7;2(5). pii: 2/5/e201900478. doi:, 10.26508/lsa.201900478. Print 2019 Oct. PMID:31591136<ref>PMID:31591136</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6jvb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa, N]]

OCA at 05:17, 10 October 2019

2019-10-10T05:17:38Z

← Older revision		Revision as of 05:17, 10 October 2019
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	~~'''Unreleased structure'''~~

	~~The entry~~ 6jvb is ~~ON HOLD until Paper Publication~~		==Crystal Structure of Human CRMP2 1-532, AGE-modified==
			<StructureSection load='6jvb' size='340' side='right'caption='[[6jvb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	~~Authors~~: ~~Jiang~~, X., ~~Ogawa~~, T., ~~Hirokawa~~, N.		== Structural highlights ==
			<table><tr><td colspan='2'>[[6jvb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JVB FirstGlance]. <br>
	~~Description~~: ~~Crystal Structure~~ of ~~Human CRMP2 1-532, AGE-modified~~		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jvb OCA], [http://pdbe.org/6jvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jvb RCSB], [http://www.ebi.ac.uk/pdbsum/6jvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jvb ProSAT]</span></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN]] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa, N]]
	[[Category: Jiang, X]]		[[Category: Jiang, X]]
	[[Category: Ogawa, T]]		[[Category: Ogawa, T]]
			[[Category: Gap activity]]
			[[Category: Microtubule associated protein]]
			[[Category: Neuronal protein]]
			[[Category: Structural protein]]

OCA at 06:55, 1 May 2019

2019-05-01T06:55:51Z

← Older revision		Revision as of 06:55, 1 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6jvb is ON HOLD		The entry 6jvb is ON HOLD until Paper Publication

	Authors: Jiang, X., Ogawa, T., Hirokawa, N.		Authors: Jiang, X., Ogawa, T., Hirokawa, N.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Hirokawa, N]]		[[Category: Hirokawa, N]]
			[[Category: Jiang, X]]
	[[Category: Ogawa, T]]		[[Category: Ogawa, T]]
	~~[[Category: Jiang, X]]~~

OCA: Protected "6jvb" [edit=sysop:move=sysop]

2019-04-24T04:47:46Z

Protected "6jvb" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:47, 24 April 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6jvb is ON HOLD Authors: Jiang, X., Ogawa, T., Hirokawa, N. Description: Crystal Structure of Human CRMP2 1-532, AGE-modified [[Category: Unrelease...

2019-04-24T04:47:43Z

New page: '''Unreleased structure''' The entry 6jvb is ON HOLD Authors: Jiang, X., Ogawa, T., Hirokawa, N. Description: Crystal Structure of Human CRMP2 1-532, AGE-modified [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 6jvb is ON HOLD

Authors: Jiang, X., Ogawa, T., Hirokawa, N.

Description: Crystal Structure of Human CRMP2 1-532, AGE-modified
[[Category: Unreleased Structures]]
[[Category: Hirokawa, N]]
[[Category: Ogawa, T]]
[[Category: Jiang, X]]