6mo2 - Revision history

OCA at 06:35, 11 October 2023

2023-10-11T06:35:22Z

← Older revision		Revision as of 06:35, 11 October 2023
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	<StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MO2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MO2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MO2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mo2 OCA], [~~http~~://pdbe.org/6mo2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mo2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mo2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mo2 ProSAT]</span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mo2 OCA], [https://pdbe.org/6mo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mo2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mo2 ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/A0A0B4L2Y4_9FLAV A0A0B4L2Y4_9FLAV] [https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hua, Y]]		[[Category: Hua Y]]
	[[Category: Huo, T]]		[[Category: Huo T]]
	[[Category: Lin, Y L]]		[[Category: Lin Y-L]]
	[[Category: Nie, S]]		[[Category: Nie S]]
	[[Category: Song, Y]]		[[Category: Song Y]]
	[[Category: Wu, F]]		[[Category: Wu F]]
	[[Category: Wu, J]]		[[Category: Wu J]]
	[[Category: Yao, Y]]		[[Category: Yao Y]]
	~~[[Category: Allosteric inhibitor]]~~
	~~[[Category: Complex]]~~
	~~[[Category: Inhibitor]]~~
	~~[[Category: Protease]]~~
	~~[[Category: Viral protein]]~~
	~~[[Category: Viral protein-inhibitor complex~~]]

OCA at 07:31, 21 May 2019

2019-05-21T07:31:45Z

@@ Line 1: / Line 1: @@
-The entry 6mo2 is ON HOLD
+==Structure of dengue virus protease with an allosteric Inhibitor that blocks replication==
-Authors:
+Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.,Yao Y, Huo T, Lin YL, Nie S, Wu F, Hua Y, Wu J, Kneubehl AR, Vogt MB, Rico-Hesse R, Song Y J Am Chem Soc. 2019 May 1;141(17):6832-6836. doi: 10.1021/jacs.9b02505. Epub 2019, Apr 23. PMID:31017399<ref>PMID:31017399</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>

OCA: Protected "6mo2" [edit=sysop:move=sysop]

2018-10-10T06:36:31Z

Protected "6mo2" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:36, 10 October 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6mo2 is ON HOLD Authors: Description: Category: Unreleased Structures

2018-10-10T06:36:30Z

New page: '''Unreleased structure''' The entry 6mo2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mo2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]