6mut - Revision history

OCA at 14:45, 13 March 2024

2024-03-13T14:45:10Z

← Older revision		Revision as of 14:45, 13 March 2024
Line 3:		Line 3:
	<SX load='6mut' size='340' side='right' viewer='molstar' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6mut' size='340' side='right' viewer='molstar' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus~~ onnurineus~~" bae et al. 2006~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_onnurineus Thermococcus onnurineus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MUT FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat~~">~~[[6mur\|6mur]]~~, [[~~6mus~~\|~~6mus]], [[6mua\|6mua~~]]</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TON_0893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~342948~~ "~~Thermococcus onnurineus~~" ~~Bae et al. 2006]), TON_0894 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0895 ([http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0897 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006])</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [https://pdbe.org/6mut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [https://www.ebi.ac.uk/pdbsum/6mut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [~~http~~://pdbe.org/6mut PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mut PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>
	</table>		</table>
	~~<div style="background-color:#fffaf0;">~~		== Function ==
	== ~~Publication Abstract from PubMed~~ ==		[https://www.uniprot.org/uniprot/CAS10_THEON CAS10_THEON] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.[UniProtKB:A0A0A7HFE1] A single-strand deoxyribonuclease (ssDNase) which digests linear and circular ssDNA; has 5'-3' and 3'-5' exonuclease activity as well as a less efficient endonuclease activity. Has a minimal size requirement; 100 nucleotide ssDNA (nt) is more efficiently digested than 50 or 25 nt ssDNA, while 14 nt ssDNA is not cleaved at all. It has no activity on dsDNA or ssRNA.<ref>PMID:25773141</ref> ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases.[UniProtKB:A0A0A7HFE1] When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids.[UniProtKB:A0A0A7HFE1]
	~~Type IotaIotaIota~~ CRISPR~~-Cas systems provide robust immunity~~ against ~~foreign RNA~~ and ~~DNA by sequence-specific RNase~~ and target RNA~~-activated sequence-nonspecific DNase and RNase activities. We report on cryo-EM structures of Thermococcus onnurineus Csm~~(crRNA) ~~binary,~~ Csm(crRNA~~)-target RNA~~ and ~~Csm(~~crRNA)-target RNA~~(anti-tag) ternary complexes in~~ the 3.1 A ~~range. The topological features of the crRNA~~ 5'-~~repeat tag explains the 5~~'~~-ruler mechanism for defining target cleavage sites, with accessibility of positions -2 to~~ -~~5 within the~~ 5'~~-repeat serving~~ as sensors for avoidance of autoimmunity. The Csm3 thumb elements introduce periodic kinks in the crRNA-target RNA duplex, facilitating cleavage of the target RNA with 6-nt periodicity. Key Glu residues within a ~~Csm1 loop segment of Csm(crRNA) adopt a proposed autoinhibitory conformation suggestive of DNase~~ activity ~~regulation~~. ~~These structural findings, complemented by mutational studies of key intermolecular contacts, provide insights into Csm~~(~~crRNA~~) ~~complex assembly~~, ~~mechanisms underlying RNA targeting and site-specific periodic cleavage, regulation of DNase cleavage~~ activity~~, and autoimmunity suppression~~.

	Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.,Jia N, Mo CY, Wang C, Eng ET, Marraffini LA, Patel DJ Mol Cell. 2018 Nov 27. pii: S1097-2765(18)30977-8. doi:, 10.1016/j.molcel.2018.11.007. PMID:30503773<ref>PMID:~~30503773~~</ref>

	~~From MEDLINE®/PubMed&reg~~;, ~~a database of~~ the U.S. ~~National Library~~ of ~~Medicine~~.~~<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 6mut" style="background-color~~:~~#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
	~~[[Category: Thermococcus onnurineus bae et al. 2006]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Eng, E T~~]]		[[Category: Thermococcus onnurineus]]
	[[Category: ~~Jia, N~~]]		[[Category: Eng ET]]
	[[Category: ~~Patel, D J~~]]		[[Category: Jia N]]
	[[Category: ~~Wang, C~~]]		[[Category: Patel DJ]]
	[[Category: ~~Cryo-em structure]]~~		[[Category: Wang C]]
	~~[[Category: Rna binding protein-rna complex]]~~
	~~[[Category: Ternary csm-crrna-target rna with anti-tag sequence complex]]~~
	~~[[Category: Type iii crispr-cas system~~]]

OCA at 02:57, 11 April 2020

2020-04-11T02:57:23Z

← Older revision		Revision as of 02:57, 11 April 2020
Line 3:		Line 3:
	<SX load='6mut' size='340' side='right' viewer='molstar' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6mut' size='340' side='right' viewer='molstar' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus onnurineus" bae et al. 2006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus onnurineus" bae et al. 2006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mur\|6mur]], [[6mus\|6mus]], [[6mua\|6mua]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mur\|6mur]], [[6mus\|6mus]], [[6mua\|6mua]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TON_0893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0894 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0897 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TON_0893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0894 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0897 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [http://pdbe.org/6mut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [http://www.ebi.ac.uk/pdbsum/6mut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [http://pdbe.org/6mut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [http://www.ebi.ac.uk/pdbsum/6mut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:38, 6 March 2020

2020-03-06T22:38:36Z

← Older revision		Revision as of 22:38, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system==		==Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system==
	<~~StructureSection~~ load='6mut' size='340' side='right' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>		<SX load='6mut' size='340' side='right' viewer='molstar' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus onnurineus" bae et al. 2006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus onnurineus" bae et al. 2006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUT FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
	</~~StructureSection~~>		</SX>
	[[Category: Thermococcus onnurineus bae et al. 2006]]		[[Category: Thermococcus onnurineus bae et al. 2006]]
			[[Category: Large Structures]]
	[[Category: Eng, E T]]		[[Category: Eng, E T]]
	[[Category: Jia, N]]		[[Category: Jia, N]]

OCA at 09:08, 19 December 2018

2018-12-19T09:08:52Z

← Older revision		Revision as of 09:08, 19 December 2018
Line 3:		Line 3:
	<StructureSection load='6mut' size='340' side='right' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6mut' size='340' side='right' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUT FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_onnurineus"_bae_et_al._2006 "thermococcus onnurineus" bae et al. 2006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mur\|6mur]], [[6mus\|6mus]], [[6mua\|6mua]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mur\|6mur]], [[6mus\|6mus]], [[6mua\|6mua]]</td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TON_0893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0894 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0895 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0896 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006]), TON_0897 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=342948 "Thermococcus onnurineus" Bae et al. 2006])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [http://pdbe.org/6mut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [http://www.ebi.ac.uk/pdbsum/6mut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [http://pdbe.org/6mut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [http://www.ebi.ac.uk/pdbsum/6mut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>
	</table>		</table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Type IotaIotaIota CRISPR-Cas systems provide robust immunity against foreign RNA and DNA by sequence-specific RNase and target RNA-activated sequence-nonspecific DNase and RNase activities. We report on cryo-EM structures of Thermococcus onnurineus Csm(crRNA) binary, Csm(crRNA)-target RNA and Csm(crRNA)-target RNA(anti-tag) ternary complexes in the 3.1 A range. The topological features of the crRNA 5'-repeat tag explains the 5'-ruler mechanism for defining target cleavage sites, with accessibility of positions -2 to -5 within the 5'-repeat serving as sensors for avoidance of autoimmunity. The Csm3 thumb elements introduce periodic kinks in the crRNA-target RNA duplex, facilitating cleavage of the target RNA with 6-nt periodicity. Key Glu residues within a Csm1 loop segment of Csm(crRNA) adopt a proposed autoinhibitory conformation suggestive of DNase activity regulation. These structural findings, complemented by mutational studies of key intermolecular contacts, provide insights into Csm(crRNA) complex assembly, mechanisms underlying RNA targeting and site-specific periodic cleavage, regulation of DNase cleavage activity, and autoimmunity suppression.

			Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.,Jia N, Mo CY, Wang C, Eng ET, Marraffini LA, Patel DJ Mol Cell. 2018 Nov 27. pii: S1097-2765(18)30977-8. doi:, 10.1016/j.molcel.2018.11.007. PMID:30503773<ref>PMID:30503773</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6mut" style="background-color:#fffaf0;"></div>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Thermococcus onnurineus bae et al. 2006]]
	[[Category: Eng, E T]]		[[Category: Eng, E T]]
	[[Category: Jia, N]]		[[Category: Jia, N]]

OCA at 06:58, 12 December 2018

2018-12-12T06:58:25Z

← Older revision		Revision as of 06:58, 12 December 2018
Line 1:		Line 1:
	~~'''Unreleased structure'''~~

	~~The entry~~ 6mut is ~~ON HOLD until Paper Publication~~		==Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system==
			<StructureSection load='6mut' size='340' side='right' caption='[[6mut]], [[Resolution\|resolution]] 3.10Å' scene=''>
	~~Authors~~:		== Structural highlights ==
			<table><tr><td colspan='2'>[[6mut]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUT FirstGlance]. <br>
	~~Description~~:		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	[[Category: ~~Unreleased Structures~~]]		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mur\|6mur]], [[6mus\|6mus]], [[6mua\|6mua]]</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mut OCA], [http://pdbe.org/6mut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mut RCSB], [http://www.ebi.ac.uk/pdbsum/6mut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mut ProSAT]</span></td></tr>
			</table>
			__TOC__
			</StructureSection>
			[[Category: Eng, E T]]
			[[Category: Jia, N]]
			[[Category: Patel, D J]]
			[[Category: Wang, C]]
			[[Category: Cryo-em structure]]
			[[Category: Rna binding protein-rna complex]]
			[[Category: Ternary csm-crrna-target rna with anti-tag sequence complex]]
			[[Category: Type iii crispr-cas system]]

OCA at 06:38, 14 November 2018

2018-11-14T06:38:04Z

← Older revision		Revision as of 06:38, 14 November 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6mut is ON HOLD		The entry 6mut is ON HOLD until Paper Publication

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OCA: Protected "6mut" [edit=sysop:move=sysop]

2018-10-31T05:34:48Z

Protected "6mut" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:34, 31 October 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6mut is ON HOLD Authors: Description: Category: Unreleased Structures

2018-10-31T05:34:46Z

New page: '''Unreleased structure''' The entry 6mut is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mut is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]