6mye - Revision history

OCA at 06:41, 11 October 2023

2023-10-11T06:41:44Z

← Older revision		Revision as of 06:41, 11 October 2023
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	<StructureSection load='6mye' size='340' side='right'caption='[[6mye]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='6mye' size='340' side='right'caption='[[6mye]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mye]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MYE FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mye]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MYE FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=FMT:FORMIC+ACID'>FMT</scene~~></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=~~NH2~~:~~AMINO~~+~~GROUP~~'>~~NH2~~</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mye OCA], [https://pdbe.org/6mye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mye RCSB], [https://www.ebi.ac.uk/pdbsum/6mye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mye ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mye OCA], [~~http~~://pdbe.org/6mye PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mye RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mye PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mye ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.		[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> [[http://www.uniprot.org/uniprot/ARHGQ_HUMAN ARHGQ_HUMAN]] Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.<ref>PMID:15133129</ref> <ref>PMID:17074883</ref> <ref>PMID:17875742</ref>		[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fuentes~~, E J~~]]		[[Category: Fuentes EJ]]
	[[Category: Gakhar, L]]		[[Category: Gakhar L]]
	[[Category: Hou, T]]		[[Category: Hou T]]
	[[Category: Sun~~, Y J]]~~		[[Category: Sun YJ]]
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Guanyl nucleotide exchange factor]]~~
	~~[[Category: Sgef/scribble/dlg1 compelx]]~~
	~~[[Category: Tight junction~~]]

OCA at 07:58, 23 October 2019

2019-10-23T07:58:09Z

← Older revision		Revision as of 07:58, 23 October 2019
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	<StructureSection load='6mye' size='340' side='right'caption='[[6mye]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='6mye' size='340' side='right'caption='[[6mye]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mye]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYE FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mye]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mye OCA], [http://pdbe.org/6mye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mye RCSB], [http://www.ebi.ac.uk/pdbsum/6mye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mye ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mye OCA], [http://pdbe.org/6mye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mye RCSB], [http://www.ebi.ac.uk/pdbsum/6mye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mye ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> [[http://www.uniprot.org/uniprot/ARHGQ_HUMAN ARHGQ_HUMAN]] Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.<ref>PMID:15133129</ref> <ref>PMID:17074883</ref> <ref>PMID:17875742</ref>		[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> [[http://www.uniprot.org/uniprot/ARHGQ_HUMAN ARHGQ_HUMAN]] Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.<ref>PMID:15133129</ref> <ref>PMID:17074883</ref> <ref>PMID:17875742</ref>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The canonical Scribble polarity complex is implicated in regulation of epithelial junctions and apical polarity. Here, we show that SGEF, a RhoG-specific GEF, forms a ternary complex with Scribble and Dlg1, two members of the Scribble complex. SGEF targets to apical junctions in a Scribble-dependent fashion and functions in the regulation of actomyosin-based contractility and barrier function at tight junctions as well as E-cadherin-mediated formation of adherens junctions. Surprisingly, SGEF does not control the establishment of polarity. However, in 3D cysts, SGEF regulates the formation of a single open lumen. Interestingly, SGEF's nucleotide exchange activity regulates the formation and maintenance of adherens junctions, and in cysts the number of lumens formed, whereas SGEF's scaffolding activity is critical for regulation of actomyosin contractility and lumen opening. We propose that SGEF plays a key role in coordinating junctional assembly and actomyosin contractility by bringing together Scribble and Dlg1 and targeting RhoG activation to cell-cell junctions.

			SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.,Awadia S, Huq F, Arnold TR, Goicoechea SM, Sun YJ, Hou T, Kreider-Letterman G, Massimi P, Banks L, Fuentes EJ, Miller AL, Garcia-Mata R J Cell Biol. 2019 Jun 27. pii: jcb.201811114. doi: 10.1083/jcb.201811114. PMID:31248911<ref>PMID:31248911</ref>

			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
			<div class="pdbe-citations 6mye" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fuentes, E J]]		[[Category: Fuentes, E J]]
	[[Category: ~~Gakahr~~, L]]		[[Category: Gakhar, L]]
	[[Category: Hou, T]]		[[Category: Hou, T]]
	[[Category: Sun, Y J]]		[[Category: Sun, Y J]]

OCA at 07:27, 10 April 2019

2019-04-10T07:27:03Z

← Older revision		Revision as of 07:27, 10 April 2019
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	~~'''Unreleased structure'''~~

	~~The entry 6mye is ON HOLD until Paper Publication~~		==Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)==
			<StructureSection load='6mye' size='340' side='right'caption='[[6mye]], [[Resolution\|resolution]] 1.10Å' scene=''>
	~~Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J.~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[6mye]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYE FirstGlance]. <br>
	~~Description:~~ Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
	[[Category: ~~Unreleased~~ Structures]]		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mye OCA], [http://pdbe.org/6mye PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mye RCSB], [http://www.ebi.ac.uk/pdbsum/6mye PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mye ProSAT]</span></td></tr>
			</table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
			== Function ==
			[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> [[http://www.uniprot.org/uniprot/ARHGQ_HUMAN ARHGQ_HUMAN]] Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.<ref>PMID:15133129</ref> <ref>PMID:17074883</ref> <ref>PMID:17875742</ref>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
			[[Category: Large Structures]]
			[[Category: Fuentes, E J]]
			[[Category: Gakahr, L]]
	[[Category: Hou, T]]		[[Category: Hou, T]]
	[[Category: ~~Gakahr~~, L]]		[[Category: Sun, Y J]]
	[[Category: ~~Sun, Y.J~~]]		[[Category: Cell adhesion]]
	[[Category: ~~Fuentes, E.J~~]]		[[Category: Guanyl nucleotide exchange factor]]
			[[Category: Sgef/scribble/dlg1 compelx]]
			[[Category: Tight junction]]

OCA at 06:31, 19 December 2018

2018-12-19T06:31:24Z

← Older revision		Revision as of 06:31, 19 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

	The entry 6mye is ON HOLD		The entry 6mye is ON HOLD until Paper Publication

	Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J.		Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J.

OCA: Protected "6mye" [edit=sysop:move=sysop]

2018-11-07T10:59:04Z

Protected "6mye" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:59, 7 November 2018
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6mye is ON HOLD Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J. Description: Crystal structure of human Scribble PDZ1 domain in complex with...

2018-11-07T10:59:03Z

New page: '''Unreleased structure''' The entry 6mye is ON HOLD Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J. Description: Crystal structure of human Scribble PDZ1 domain in complex with...

New page

'''Unreleased structure'''

The entry 6mye is ON HOLD

Authors: Sun, Y.J., Hou, T., Gakahr, L., Fuentes, E.J.

Description: Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)
[[Category: Unreleased Structures]]
[[Category: Hou, T]]
[[Category: Gakahr, L]]
[[Category: Sun, Y.J]]
[[Category: Fuentes, E.J]]