6o7f - Revision history

OCA at 14:50, 13 March 2024

2024-03-13T14:50:57Z

← Older revision		Revision as of 14:50, 13 March 2024
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	==Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine==		==Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine==
	<StructureSection load='6o7f' size='340' side='right'caption='[[6o7f]]' scene=''>		<StructureSection load='6o7f' size='340' side='right'caption='[[6o7f]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6O7F FirstGlance]. <br>		<table><tr><td colspan='2'>[[6o7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O7F FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6o7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7f OCA], [~~http~~://pdbe.org/6o7f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o7f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o7f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7f ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.303Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NKV:N-(2-methylpropanoyl)adenosine'>NKV</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7f OCA], [https://pdbe.org/6o7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o7f RCSB], [https://www.ebi.ac.uk/pdbsum/6o7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7f ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
			== References ==
			<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
			[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Hung L-W]]		[[Category: Hung L-W]]
	[[Category: Kim C-Y]]		[[Category: Kim C-Y]]
	[[Category: Kim H-B]]		[[Category: Kim H-B]]
	[[Category: Terwilliger TC]]		[[Category: Terwilliger TC]]

OCA at 09:30, 9 September 2020

2020-09-09T09:30:28Z

← Older revision		Revision as of 09:30, 9 September 2020
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	~~'''Unreleased structure'''~~

	~~The entry 6o7f is ON HOLD~~		==Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine==
			<StructureSection load='6o7f' size='340' side='right'caption='[[6o7f]]' scene=''>
	~~Authors: Kim, H.-B., Hung, L.-W., Terwilliger, T.C., Kim, C.-Y., Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)~~		== Structural highlights ==
			<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6O7F FirstGlance]. <br>
	~~Description:~~ Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6o7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7f OCA], [http://pdbe.org/6o7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o7f RCSB], [http://www.ebi.ac.uk/pdbsum/6o7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7f ProSAT]</span></td></tr>
	[[~~Category~~: ~~Unreleased Structures~~]]		</table>
	[[~~Category~~: ~~Terwilliger~~, T.C]]		__TOC__
	[[Category: Structures ~~Of Mtb Proteins Conferring Susceptibility To Known Mtb Inhibitors (Mtbi)~~]]		</StructureSection>
	[[Category: Hung, L.-W]]		[[Category: Large Structures]]
	[[Category: Kim, H.-B]]		[[Category: Hung L-W]]
	[[Category: ~~Kim, C.-Y~~]]		[[Category: Kim C-Y]]
			[[Category: Kim H-B]]
			[[Category: Terwilliger TC]]

OCA: Protected "6o7f" [edit=sysop:move=sysop]

2019-03-13T10:19:24Z

Protected "6o7f" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:19, 13 March 2019
(No difference)

OCA: New page: '''Unreleased structure''' The entry 6o7f is ON HOLD Authors: Kim, H.-B., Hung, L.-W., Terwilliger, T.C., Kim, C.-Y., Structures of Mtb Proteins Conferring Susceptibility to Known Mtb I...

2019-03-13T10:19:23Z

New page: '''Unreleased structure''' The entry 6o7f is ON HOLD Authors: Kim, H.-B., Hung, L.-W., Terwilliger, T.C., Kim, C.-Y., Structures of Mtb Proteins Conferring Susceptibility to Known Mtb I...

New page

'''Unreleased structure'''

The entry 6o7f is ON HOLD

Authors: Kim, H.-B., Hung, L.-W., Terwilliger, T.C., Kim, C.-Y., Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)

Description: Mycobacterium tuberculosis L-alanine dehydrogenase x-ray structure in complex with N6-isobutyl adenosine
[[Category: Unreleased Structures]]
[[Category: Terwilliger, T.C]]
[[Category: Structures Of Mtb Proteins Conferring Susceptibility To Known Mtb Inhibitors (Mtbi)]]
[[Category: Hung, L.-W]]
[[Category: Kim, H.-B]]
[[Category: Kim, C.-Y]]